We propose a systematic study of transformations of A-hypergeometric functions. Our approach is to apply changes of variables corresponding to automorphisms of toric rings, to Euler-type integral representations of A-hypergeometric functions. We show that all linear Ahypergeometric transformations arise from symmetries of the corresponding polytope. As an application of the techniques developed here, we show that the Appell function F 4 does not admit a certain kind of Euler-type integral representation.valid for Re(c) > Re(b) > 0 and |x| < 1, and where B denotes the beta function.On the one hand, transformation formulas are abundant in the hypergeometric literature, see, e.g., reference works such as [AAR99, EMOT53, NIST]. Of particular note is the work of Vidūnas, culminating in [Vid09], which classifies algebraic transformations for the Gauss hypergeometric function. On the other hand, the known hypergeometric transformations mostly involve only a few of the most classical families of hypergeometric functions, essentially those named after Gauss, Appell, and Lauricella.