“…In culture, the basal production of CXCL8 was significantly increased in scleroderma fibroblasts compared to controls, and these fibroblasts produce CXCL1 that, in turn, chemoattracts macrophages. Serum levels of CXCL8, CCL2, 3, and 4 were significantly elevated in patients with scleroderma compared with normal individuals, [178][179][180] and the levels of CXCL8, CCL3, and 3 were higher in lung lavage fluids from scleroderma patients, especially those with lung complications. [181][182] In skin samples from affected patients, the expression of CCL2 and 5 is high with CCL2 being expressed in the epidermis, inflammatory mononuclear cells, and vascular endothelial cells, and CCL5 in the epidermis.…”