Eukaryotic initiation Factor 4AIII facilitates hepatocellular carcinoma cell proliferation, migration, and epithelial‐mesenchymal transition process via antagonistically binding to WD repeat domain 66 with miRNA‐2113

Zhang, Li; Chen, Yangzong; Bao, Chunchun; Zhang, Xiu-Xing; Li, Haiying

doi:10.1002/jcp.29475

Cited by 12 publications

(12 citation statements)

References 36 publications

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“…The eIF4F translation initiation complex controls the translation initiation rates of many pro-oncogenic mRNAs and serves as a critical node under the regulation of the PI3K/Akt/mTOR signaling pathway (Lin et al, 2008), the mitogen-activated protein kinase signal transduction pathway, and the caspase-dependent apoptotic pathway (Blagden and Willis, 2011). As an important component of eIF4F, eIF4A1 plays a vital role in malignant transformation and progression, and recent evidence has shown that eIF4A1 is dysregulated in gastric cancer (GC) (Gao et al, 2020), colorectal cancer (Li W. et al, 2017), cervical cancer (Liang et al, 2014), hepatocellular carcinoma (Zhang et al, 2020), ovarian cancer (Zhang et al, 2018), and other cancers.…”

Section: Role Of Eif4a1 In Translation Initiationmentioning

confidence: 99%

Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers

Xue

et al. 2021

Front. Cell Dev. Biol.

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The dysregulation of mRNA translation is common in malignancies and may lead to tumorigenesis and progression. Eukaryotic initiation factor 4A (eIF4A) proteins are essential for translation, exhibit bidirectional RNA helicase function, and act as RNA-dependent ATPases. In this review, we explored the predicted structures of the three eIF4A isoforms (eIF4A1, eIF4A2, and eIF4A3), and discussed possible explanations for which function during different translation stages (initiation, mRNA localization, export, and mRNA splicing). These proteins also frequently served as targets of microRNAs (miRNAs) or long noncoding RNAs (lncRNAs) to mediate epithelial-mesenchymal transition (EMT), which was associated with tumor cell invasion and metastasis. To define the differential expression of eIF4A family members, we applied the Tumor Immune Estimation Resource website. We figured out that the eIF4A family genes were differently expressed in specific cancer types. We also found that the level of the eIF4A family genes were associated with abundant immune cells infiltration and tumor purity. The associations between eIF4A proteins and cancer patient clinicopathological features suggested that eIF4A proteins might serve as biomarkers for early tumor diagnosis, histological classification, and clinical grading/staging, providing new tools for precise and individualized cancer treatment.

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Section: Role Of Eif4a1 In Translation Initiationmentioning

confidence: 99%

Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers

Xue

et al. 2021

Front. Cell Dev. Biol.

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“…It was found that HCC cellular proliferation and migration could be suppressed through knocking down EIF4AIII, which expression level increased in HCC (Zhang et al, 2020). Thus, it might be suggested that EIF4AIII may bind to hsa_circ_0064286 causing its downregulation and inhibition of its possible tumor suppressor activity.…”

Section: Discussionmentioning

confidence: 99%

Circular RNAs 0064286 and 0000475: Potential Diagnostic Biomarkers in Hepatocellular Carcinoma

Sharkawi

Awad

Elagawy

et al. 2021

Asian Pac J Cancer Prev

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Objective: Hepatocellular carcinoma (HCC) is considered the highest recorded malignancy in Egypt. The shortage of appropriate biomarkers for early detection often results in the late diagnosis of the HCC. Circular RNAs (CircRNAs) are presented as long stranded non-coding RNA that combine covalently to make a sealed circular form which make them very stable. CircRNAs are known to have interpretative role in cancer development and metastasis. Aim: To examine the dysregulation of two new CircRNAs obtained from Circbase database (hsa_circ_0064286 and hsa_circ_0000475) in the serum of HCC patients as predictable diagnostic biomarkers of HCC and their correlation with some liver biochemical parameters. Methods: Sixty clinically diagnosed HCC Egyptian patients and 25 healthy volunteers were enrolled in the study. Expression levels of the selected CircRNAs was evaluated in subjects' serum. Moreover, correlation with liver biochemical parameters, sensitivity, and specificity of studied CircRNAs were estimated. Results: Both circular RNAs were significantly down regulated in HCC patients, which was negatively correlated with ALP, ALT, AST, AFP, and bilirubin levels. Circ_0064286 showed more sensitivity and specificity (88.3% and 96%, respectively). Conclusion:As far as we know, this is the first study that shed light on the expression levels of both circRNAs in Egyptian HCC patients. They may serve as potential biomarkers for HCC diagnosis. Moreover, those circRNAs draw attention as therapeutic targets for HCC through targeting their sponge miRNAs.

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“… 40 Another factor, namely eIF4AIII, was found to be overexpressed in HCC and promoted tumor cell proliferation and migration. 44 eIF4AII was identified as a host factor supporting HCV replication in different replication systems, in contrast to eIF4AI where an opposite function was observed. 45 A study on HepG2 cells showed that eIF4E phosphorylation with Mnk inhibitor blockage could be a new therapeutic option against chemoresistant HCC.…”

Section: Translation Control Upon Viral Infection and As Response To Non-virally Triggered Stressmentioning

confidence: 99%

Translational Regulation in Hepatocellular Carcinogenesis

Tomazic¹,

Schatz²,

Haybaeck³

2021

DDDT

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The mortality of hepatocellular carcinoma (HCC) is distributed unevenly worldwide. One of the major causes is hepatitis B or hepatitis C virus infection and the development and progression of liver cirrhosis. The carcinogenesis of HCC is among others regulated via the mTOR (mechanistic target of rapamycin) signaling pathway and represents a possible method of targeted treatment. The aim of our article was to address the most recent clinical advances and findings of basic studies on the mTOR signaling pathway and the involved factors. Risk factors play a key role in dysregulation of the signaling pathway, where both mTORCs are upregulated and protein synthesis is altered. eIFs and, to a lesser extent, eEFs play an essential role in this process. Whether the factor will be upregulated or downregulated, among others, depends on hepatitis B/C virus infection. The amount of a particular factor in a patient sample lets us know whether HCC recurrence will occur, what is the likelihood of chemoresistance, and what outcome is predicted for patients with an increased value. Our analysis shows that in addition to mTOR, eIF3, eIF4, and eIF5 play an important role, as they can serve as biomarkers for non-and virus-related HCC.

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Eukaryotic initiation Factor 4AIII facilitates hepatocellular carcinoma cell proliferation, migration, and epithelial‐mesenchymal transition process via antagonistically binding to WD repeat domain 66 with miRNA‐2113

Cited by 12 publications

References 36 publications

Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers

Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers

Circular RNAs 0064286 and 0000475: Potential Diagnostic Biomarkers in Hepatocellular Carcinoma

Translational Regulation in Hepatocellular Carcinogenesis

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