“…In eukaryotes, replication of the nuclear genome is largely conducted by three members of the B family of DNA polymerases, polymerases α, ε, and δ (Pols α, ε, and δ, respectively). Polymerase α mainly synthesizes short RNA–DNA primers to initiate replication, while Pols ε and δ are responsible for DNA chain elongation (Bell & Labib, ; Burgers & Kunkel, ; M. A. Garbacz et al, ; Lujan, Williams, & Kunkel, ; Stodola & Burgers, ). One model supports that Pol ε replicates the leading DNA strand, while the lagging strand is primarily conducted by Pol δ.…”