Eugenol isolated from the essential oil of Eugenia caryophyllata induces a reactive oxygen species-mediated apoptosis in HL-60 human promyelocytic leukemia cells

Yoo, Chae-Bin; Han, Ki-Tae; Cho, Kyu-Seok; Ha, Joohun; Park, Hee-Juhn; Nam, Jung‐Hwan; Kil, Uk-Hyun; Lee, Kyung‐Tae

doi:10.1016/j.canlet.2004.11.018

Cited by 208 publications

(117 citation statements)

References 36 publications

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“…The study observed that EU transduced the apoptotic signal via ROS generation, thereby inducing mitochondrial permeability transition, reducing anti-apoptotic protein Bcl-2 level, inducing cytochrome c release to the cytosol and subsequent apoptotic cell death. This study demonstrated that ROS plays a critical role in EU induced apoptosis in HL-60, and this is the first report on the mechanism of the anticancer effect of EU [43].…”

Section: Anticancer Activity Of Phenylpropanoids Eu Scaffold and Itssupporting

confidence: 54%

Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

Fadilah

Yanuar²,

Arsianti³

et al. 2017

Asian J Pharm Clin Res

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Eugenol (EU) is a phenylpropene, an allyl chain-substituted guaiacol. EU is a member of the phenylpropanoids class of chemical compounds. It is a colorless to pale yellow oily liquid extracted from certain essential oils especially from clove oil. Further, chemopreventive agents might be used singly or in combination with chemotherapy or radiotherapy for the more effective treatment of cancer by enhancing the efficacy of these modalities with minimal side effects and toxicity. Considering that EU scaffold may be a prospective chemopreventive agent, its potent antitumor ability to interfere with solid cancer cell growth and its molecular mechanism were evaluated as an initiative toward the development of a novel strategy for cancer treatment. This review article will conduct that EU as the antiproliferative activity and molecular mechanism of the EU induced apoptosis against the cancer cells and animal models.

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Section: Anticancer Activity Of Phenylpropanoids Eu Scaffold and Itssupporting

confidence: 54%

Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

Fadilah

Yanuar²,

Arsianti³

et al. 2017

Asian J Pharm Clin Res

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“…The data obtained indicated that carvacrol, which is a very potent inhibitor of cell growth in A549 cell line, could have an anticarcinogenic effect. The effect of eugenol that is a major component of EO isolated from the Eugenia caryophyllata (Myrtaceae), in particular its anticancer effect upon HL-60 human promyelocytic leukemia cells, was investigated by Yoo et al [40]. The authors found that EO -mediated apoptosis in HL-60 cells occurs via reactive oxidative species (ROS) generation that forms eugenol phenoxyl radicals.…”

mentioning

confidence: 99%

Cytotoxic, anti-carcinogenic and antioxidant properties of the most frequent plant volatiles

Slameñová¹,

Horváthová²

2013

neo

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Flowers, berries, leaves, barks and roots of different plants have been used through the ages as a source of flavor in food and perfume preparations. The volatiles responsible for the flavor of botanicals can be extracted from the plant material as "essential oils" (EOs), called also volatile oils or ethereal oils. The term essential is intended to indicate that the oil is the fragrant essence of the plant from which it is extracted. EOs are constituted by hydrocarbons (monoterpenes and sesquiterpenes) and oxygenated compounds (alcohols, esters, ethers, aldehydes, ketones, lactones, phenols and phenol ethers). Of the numerous groups of naturally occurring compounds examined so far terpenes are known as fragrances and flavoring agents. The data reported in this review including the data obtained in our laboratory show that many of EOs exhibit a range of biological activities inclusive of antioxidative, anti-mutagenic and anti-carcinogenic activities. Most of them belong to phytochemicals with chemopreventive potential. On the other hand some herbal products can cause serious adverse effects. A complex research of toxic, genotoxic, anti-mutagenic and anti-carcinogenic effects of EOs is therefore very important.

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“…Eugenol is a major component of essential oil isolated from the E. caryophyllata, which was reported as an anticancer agent [26]. The root tuber protein of Richosanthes kirilowii suppressed the HSV-1 infection by targeting the mitogen-activated protein kinase (MAPK) family pathway [27].…”

Section: Resultsmentioning

confidence: 99%

Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro

et al. 2007

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Bone undergoes continuous remodeling through bone formation and resorption, and maintaining the balance for skeletal rigidity. Bone resorption and loss are generally attributed to osteoclasts. Differentiation of osteoclasts is regulated by receptor activator of nuclear factor NF-kB ligand (RANKL), a member of tumor necrosis factor family. When the balance is disturbed, pathological bone abnormality ensues. Through the screening of traditional Korean medicinal plants, the effective molecules for inhibition and stimulation of RANKL-induced osteoclast differentiation in mouse bone marrow macrophages were identified. Among 222 methanol extracts, of medicinal plants, 10 samples exhibited ability to induce osteoclast differentiation. These include Dryobalanops aromatica, Euphoria longana, Lithospermum erythrorhizon, Prunus mume, Prunus nakaii, and Polygonatum odoratum. In contrast, Ailanthus altissima, Curcuma longa, Solanum nigrum, Taraxacum platycarpa, Trichosanthes kirilowii, and Daphne genkwa showed inhibitory effects in RANKLinduced osteoclast differentiation.

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Eugenol isolated from the essential oil of Eugenia caryophyllata induces a reactive oxygen species-mediated apoptosis in HL-60 human promyelocytic leukemia cells

Cited by 208 publications

References 36 publications

Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

Cytotoxic, anti-carcinogenic and antioxidant properties of the most frequent plant volatiles

Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro

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