Eugenol allergy mimicking recurrent aphthous stomatitis and burning mouth syndrome

Navarro‐Triviño, Francisco José; Cuenca‐Barrales, Carlos; Ruiz‐Villaverde, Ricardo

doi:10.1111/cod.13365

Cited by 12 publications

(4 citation statements)

References 4 publications

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“…Although the antimicrobial activity of eugenol and carvacrol is well documented, these phenols could cause irritation, allergy, and, therefore, exert toxicity at certain concentrations [97,106,107].…”

Section: Discussionmentioning

confidence: 99%

Potential Applications of Essential Oils for Environmental Sanitization and Antimicrobial Treatment of Intensive Livestock Infections

et al. 2022

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The extensive use of antibiotics has contributed to the current antibiotic resistance crisis. Livestock infections of Salmonella spp, Clostridium spp. and E. coli antimicrobial-resistant bacteria represent a public threat to human and animal health. To reduce the incidence of these zoonoses, essential oils (EOs) could be effective antibiotic alternatives. This study aims at identifying EOs safe for use, effective both in complementary therapy and in the environmental sanitization of intensive farming. Natural products were chemo-characterized by gas chromatography. Three S. Typhimurium, three C. perfringens and four E. coli strains isolated from poultry and swine farms were used to assess the antimicrobial properties of nine EOs and a modified GR-OLI (mGR-OLI). The toxicity of the most effective ones (Cinnamomum zeylanicum, Cz; Origanum vulgare, Ov) was also evaluated on porcine spermatozoa and Galleria mellonella larvae. Cz, Ov and mGR-OLI showed the strongest antimicrobial activity; their volatile components were also able to significantly inhibit the growth of tested strains. In vitro, Ov toxicity was slightly lower than Cz, while it showed no toxicity on G. mellonella larvae. In conclusion, the study confirms the importance of evaluating natural products to consolidate the idea of safe EO applications in reducing and preventing intensive livestock infections.

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Section: Discussionmentioning

confidence: 99%

Potential Applications of Essential Oils for Environmental Sanitization and Antimicrobial Treatment of Intensive Livestock Infections

et al. 2022

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“…Despite many important properties, eugenol can cause irritation and allergy. There have been reports of allergic contact dermatitis, presenting as hand eczema in dentistry workers like dentists or dental assistants (due to the use of eugenol in dentistry), as well as allergic contact gingivitis or burning mouth syndrome [ 12 ].…”

Section: Characteristics Of Eugenolmentioning

confidence: 99%

Biological Properties and Prospects for the Application of Eugenol—A Review

Ulanowska

Olas

2021

IJMS

238

115

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Eugenol is a phenolic aromatic compound obtained mainly from clove oil. Due to its known antibacterial, antiviral, antifungal, anticancer, anti-inflammatory and antioxidant properties, it has long been used in various areas, such as cosmetology, medicine, and pharmacology. However, high concentrations can be toxic. A dose of 2.5 mg/kg body weight is regarded as safe. This paper reviews the current state of knowledge regarding the activities and application of eugenol and its derivatives and recent research of these compounds. This review is based on information concerning eugenol characteristics and recent research from articles in PubMed. Eugenol remains of great interest to researchers, since its multidirectional action allows it to be a potential component of drugs and other products with therapeutic potential against a range of diseases.

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“…Although excessive amounts of eugenol can cause harmful effects, a concentration of 2.5 mg/kg body weight is commonly considered harmless. Due to its use in dentistry, there are cases of hand eczema, in addition to burning mouth syndrome (BMS) or allergic contact gingivitis [ 44 ].…”

Section: Eugenol Characteristicsmentioning

confidence: 99%

Anticancer Properties of Eugenol: A Review

2021

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Conventional cancer treatments have shown several unfavourable adverse effects, as well as an increase in anticancer drug resistance, which worsens the impending cancer therapy. Thus, the emphasis is currently en route for natural products. There is currently great interest in the natural bioactive components from medicinal plants possessing anticancer characteristics. For example, clove (Syzygium aromaticum L.) (Family Myrtaceae) is a highly prized spice that has been historically utilized as a food preservative and for diverse medical uses. It is reckoned amongst the valued sources of phenolics. It is indigenous to Indonesia but currently is cultivated in various places of the world. Among diverse active components, eugenol, the principal active component of S. aromaticum, has optimistic properties comprising antioxidant, anti-inflammatory, and anticancer actions. Eugenol (4-allyl-2-methoxyphenol) is a musky oil that is mainly obtained from clove. It has long been utilized all over the world as a result of its broad properties like antioxidant, anticancer, anti-inflammatory, and antimicrobial activities. Eugenol continues to pique investigators’ interest because of its multidirectional activities, which suggests it could be used in medications to treat different ailments. Anticancer effects of eugenol are accomplished by various mechanisms like inducing cell death, cell cycle arrest, inhibition of migration, metastasis, and angiogenesis on several cancer cell lines. Besides, eugenol might be utilized as an adjunct remedy for patients who are treated with conventional chemotherapy. This combination leads to a boosted effectiveness with decreased toxicity. The present review focuses on the anticancer properties of eugenol to treat several cancer types and their possible mechanisms.

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Eugenol allergy mimicking recurrent aphthous stomatitis and burning mouth syndrome

Cited by 12 publications

References 4 publications

Potential Applications of Essential Oils for Environmental Sanitization and Antimicrobial Treatment of Intensive Livestock Infections

Potential Applications of Essential Oils for Environmental Sanitization and Antimicrobial Treatment of Intensive Livestock Infections

Biological Properties and Prospects for the Application of Eugenol—A Review

Anticancer Properties of Eugenol: A Review

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