Eu³⁺-Functionalized Covalent Organic Framework Hybrid Material as a Sensitive Turn-On Fluorescent Switch for Levofloxacin Monitoring in Serum and Urine

Abstract

The research on luminescent lanthanide-functionalized covalent organic framework (COF)-based hybrid materials has not been reported so far. When a straightforward functionalized modification strategy is employed, a chemical stable Eu3+-modified COF hybrid material, Eu@TpPa-1, is first developed. The functional process does not affect the size and shape of TpPa-1, but after the introduction of Eu3+, Eu@TpPa-1 as a fluorescence sensor exhibits a turn-on response toward levofloxacin. Eu3+ plays a bridge role in the whole detection system, and TpPa-1 serves as a host matrix to provide protection for the introduced Eu3+. This reusable sensor shows strong pink-white and yellow emissions toward the high and low concentration ranges of levofloxacin, respectively. It displays excellent sensitivity and fast response to levofloxacin within 1 min, while refraining from the interference of other coexisting species in serum and urine. The good selectivity and high antidisturbance lead Eu@TpPa-1 to be successfully applied in serum and urine systems for sensing levofloxacin.

Developing Luminescent Ratiometric Thermometers Based on a Covalent Organic Framework (COF)

“…Very recently, some of us have reported the first example of a COF material grafted with lanthanides, where we show the possibility to obtain white‐light emission . Soon afterwards, several reports on lanthanide COFs have followed, showing the large interest in this research field . Also, it is worth mentioning that white light can be obtained just from a COF itself, and several luminescent materials like this have already been reported …”

“…[25] Soon afterwards, several reports on lanthanide COFs have followed, showing the large interest in this research field. [26][27][28] Also,i tis worth mentioning that white light can be obtained just from aCOF itself,and several luminescent materials like this have already been reported. [29][30][31] TheTpBpy-COF,p repared by combining 1,3,5-triformylphloroglucinol (Tp) and 2,2'-bipyridine-5,5'-diamine (Bpy), was synthesized in as olvothermal route yielding ah igh surface area and strong light-absorbing properties.I th as caught our attention as ap ossible support for grafting lanthanide complexes and obtaining temperature-dependent luminescence materials for application as ratiometric temperature sensors.…”

A hydrostable CuII coordination network prepared hydrothermally as a “turn-on” fluorescent sensor for S2− and a selective adsorbent for methylene blue

“…3e. By employing the formula 3σ/k (where σ is the standard variance of 10 blank samples), 35 the lowest detection limit (LOD) of CuCP for Na 2 S is calculated to be 63 nM.…”

Sensitized Lanthanide Photoluminescence Based Sensors–a Review

“…Such materials have been used in the detection of analytes such as ionic species, [68] small molecules, [69] volatile organic molecules, [70] biomolecules [71] etc . For example, Yan ’s group has used lanthanide MOFs [72] to sense and detect molecules such as Levofloxacin, [73] pyrethroids, [74] nitrophenols, [75] mitoxantrone, [76] diphenyl phosphate, [77] 4‐aminophenol [78] and 5‐fluorouracil [79] . Hao et.…”