Etude statistique des corrélations entre les critères spirographiques et les pressions partielles d’oxygène et d’anhydride carbonique dans le sang artériel

Neukirch, F; Perron, Du; Verdier, F; Legrand, M; Bréant, J; Mf, Fleury; Marion, Chad R.; Drutel, P

doi:10.1159/000193646

Cited by 3 publications

(3 citation statements)

References 6 publications

(6 reference statements)

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“…It is thus of importance, for both theo retical and practical purposes, to understand the relationships between PaC02 on the one hand, and arterial oxygen tension (Pa02) and ventilatory function on the other. Such data were reported by several studies, but either the number of patients was small [1,12,16,17] or, when larger groups were studied, patients with specific lung diseases [15] or with bronchial asthma [8] were in cluded; the groups were also inhomoge neous with respect to sex, clinical status and severity of airway obstruction. We thus de cided to assess the relationships mentioned above in a group of male patients with chronic nonspecific lung disease with severe airway obstruction, at distance from cardio respiratory decompensation, looking for possible differences between those with chronic bronchitis and those with emphyse ma.…”

mentioning

confidence: 87%

Relationships of Carbon Dioxide Retention to Ventilatory Impairment and Hypoxemia in Chronic Obstructive Lung Disease

Teculescu¹,

Racoveanu²,

Manicatide³

1979

Respiration

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In a group of 80 male patients (average age 52.5 years) with severe obstructive ventilatory impairment (FEV_{1 0} less than 40% of predicted) due to chronic bronchitis and/or emphysema, the blood carbon dioxide tension measured at rest, in a stable clinical status, was confronted to the spirometric variables and the oxygen tension. PaCO₂ (range 31–60 mm Hg) was loosely related to the VC (r = -0.28) and the FEV (r = -0.30, both p < 0.05) and strongly related to the PaO₂ (r = 0.60; p < 0.001). When patients were classified as bronchitic or emphysematous according to clinical, roentgenologic and biological criteria, the correlations above were found to be higher for bronchitics. In patients with chronic bronchitis with severe obstruction a very good estimation of PaCO₂ is possible from PaO₂: PaCO₂ = 75.8–0.44 PaO₂ (SEE 0.1 mm Hg).

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mentioning

confidence: 87%

Relationships of Carbon Dioxide Retention to Ventilatory Impairment and Hypoxemia in Chronic Obstructive Lung Disease

Teculescu¹,

Racoveanu²,

Manicatide³

1979

Respiration

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“…Les sujets examinés, ainsi que les techniques de mesures spirographiques et hémorespiratoires, ont été décrits dans le travail antérieur déjà cité [1].…”

Section: Méthodeunclassified

“…Une étude statistique antérieure [1] a montré qu'un groupe de 152 malades, at teints d'affections chroniques bronchopul monaires, est défini sur le plan physiopa thologique par un trouble spirographique obstructif et restrictif, associé à une hypo xémie hypercapnique.…”

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Etude statistique des corrélations entre les critères spirographiques et les pressions partielles d’oxygène et d’anhydride carbonique dans le sang artériel

Neukirch¹,

Bréant²,

Mf³

et al. 1977

Respiration

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PaO₂ and PaCO₂, after 5 min of a 40-Watt exercise, and spirometric data have been statistically evaluated in 152 patients with chronic obstructive bronchitis. In these patients, the hypoventilation syndrome increases during exercise. The correlation between age and PaO₂ is identical during rest and exercise, but the correlation between PaO₂ or PaCO₂ and FEv₁ (% predicted) is closer during exercise than during rest. The value 50 of the FEV₁ (% predicted) divides the patients into two groups: the patients who stay normocapnic and those who become hypercapnic or increase their hypercapnemia. These data show the interest of the FEV₁ (% predicted) values and allow to explain the evolution of the arterial blood gas tensions during exercise.

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The value of forced expiratory volume in 1 s in screening subjects with stable COPD for PaO2 < 7·3 kPa qualifying for long-term oxygen therapy

Lim¹,

MacRae²,

Seed³

et al. 1998

Respiratory Medicine

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Guidelines on the management of chronic obstructive pulmonary disease (COPD) issued by the European Respiratory Society (ERS), British Thoracic Society (BTS), American Thoracic Society (ATS), and Department of Health for England and Wales (DoH) suggest differing values of forced expiratory volume in 1 s (FEV1) below which arterial blood gas analysis should be performed to determine the presence of severe hypoxaemia and possible long-term oxygen therapy (LTOT) requirement. This study aimed to determine the value of FEV1 at these different levels in screening for LTOT requirement defined as PaO2 < 7.3 kPa in subjects with stable COPD. Comparative measures were taken against other lung function tests of volume and diffusing capacity. A retrospective analysis of paired lung function and arterial oxygen measurements in 491 subjects was made. The positive and negative predictive values, sensitivity and specificity of FEV1 < 70% predicted (ERS), FEV1 < 50% predicted (ATS), FEV1 < 40% predicted (BTS) and FEV1 < 1.51 (DoH) were determined for fulfilling LTOT criteria (PaO2 < 7.3 kPa). The correlation between lung function variables and PaO2 was established. Logistic regression analysis was used to classify subjects with PaO2 < 7.3 kPa and PaO2 > or = 7.3 kPa. Using FEV1 to screen for LTOT requirement produced a high negative predictive value at all four suggested limits (FEV1 < 70% 100%, FEV1 < 50% 96%, FEV1 < 40% 95%, FEV1 < 1.51 97%). However, the positive predictive values were low (FEV1 < 70% 13%, FEV1 < 50% 16%, FEV1 < 40% 19%, FEV1 < 1.51 15%) as were sensitivities. No single lung function variable was a strong determinant of PaO2. FEV1 % pred (r = 0.40), FVC % pred (r = 0.34) and TLCO % pred (r = 0.27) had the strongest relationships. Logistic regression also placed FEV1 % pred and TLCO % pred as the best predictors of PaO2 < 7.3 kPa. We conclude no lung function variable correlates well with PaO2 in subjects with stable COPD. The best predictor of PaO2 < 7.3 kPa was FEV1 % pred. Whilst a low FEV1 is a poor predictor of LTOT requirement in an individual, PaO2 < 7.3 kPa is only found in subjects with a low FEV1. A high FEV1 may be used to exclude subjects from further investigation for LTOT and prevent unnecessary arterial sampling.

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Etude statistique des corrélations entre les critères spirographiques et les pressions partielles d’oxygène et d’anhydride carbonique dans le sang artériel

Cited by 3 publications

References 6 publications

Relationships of Carbon Dioxide Retention to Ventilatory Impairment and Hypoxemia in Chronic Obstructive Lung Disease

Relationships of Carbon Dioxide Retention to Ventilatory Impairment and Hypoxemia in Chronic Obstructive Lung Disease

Etude statistique des corrélations entre les critères spirographiques et les pressions partielles d’oxygène et d’anhydride carbonique dans le sang artériel

The value of forced expiratory volume in 1 s in screening subjects with stable COPD for PaO2 < 7·3 kPa qualifying for long-term oxygen therapy

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