Étude rétrospective de l’évaluation et de la prise en charge du syndrome de sevrage brutal en benzodiazépine en milieu hospitalier entre 2000 et 2015

Martin-Kleisch, A.; Zulfiqar, Abrar-Ahmad

doi:10.1016/j.pharma.2016.11.003

Annales Pharmaceutiques Françaises

2017

DOI: 10.1016/j.pharma.2016.11.003

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Étude rétrospective de l’évaluation et de la prise en charge du syndrome de sevrage brutal en benzodiazépine en milieu hospitalier entre 2000 et 2015

A. Martin-Kleisch¹,

Abrar-Ahmad Zulfiqar

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Benzodiazepine Withdrawal

Wright¹

2020

The Benzodiazepines Crisis

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Benzodiazepines and related compounds (benzodiazepine receptor agonists [BzRAs]) cause a wide range of adverse reactions, including withdrawal symptoms, even when normal or low dosages are used. Deprescribing is recommended when there is loss of efficacy, major side effects, or use longer than four weeks. The withdrawal syndrome is due to physiologic dependence based on various receptor adaptations. Psychological, neurophysiologic, and somatic complaints can be misdiagnosed as psychiatric, psychosomatic, or substance use disorder. These symptoms may be severe and prolonged. The discontinuation process should include careful planning, support, and the use of cognitive behavioral therapy. Tapering, perhaps after substituting with a long-acting BzRA, should be patient-led and proceed slowly, anticipating completion over 12 to 18 months or even longer. In a proportion of patients, symptoms may continue months or years after complete BzRA cessation, requiring ongoing medical care.

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Benzodiazepine Withdrawal

Wright¹

2020

The Benzodiazepines Crisis

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Étude rétrospective de l’évaluation et de la prise en charge du syndrome de sevrage brutal en benzodiazépine en milieu hospitalier entre 2000 et 2015

Cited by 1 publication

References 21 publications

Benzodiazepine Withdrawal

Benzodiazepine Withdrawal

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