Etude épidémiologique des anticorps anti-HCV chez les donneurs de sang en Tunisie

Hmida, Slama; Mojaat, N.; Dahri, R.; Boukef, K.

doi:10.1016/s1140-4639(05)80140-6

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…Thus, the prevalence reported above reflects HCV transmission within the different age groups in the absence of any specific anti-HCV preventive measures. Previous studies described HCV prevalences of 0.7-1.1% in Tunisian blood donors between 1991 and 1997 [Slama et al, 1991;Abid et al, 1997] and increased prevalence (12%) in multitransfused Tunisian patients [Slama et al, 1992]. These data, together with the findings reported above, provide the baseline information needed to assess the impact of screening of blood donors for HCV transmission by blood transfusion.…”

Section: Discussionsupporting

confidence: 51%

Contrasting patterns of hepatitis C virus infection in two regions from Tunisia

Mejri

Salah

Triki

et al. 2005

Journal of Medical Virology

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This report is a population-based study describing the pattern of hepatitis C virus (HCV) infection in two distinct regions in Tunisia. The study included a total of 11,507 individuals sampled in 1996 from both genders, all age groups, urban and rural settings belonging to 2,973 families. HCV infection was assessed by commercial enzyme immunoassay (EIA) and immunoblot assays and detection of HCV RNA by PCR. HCV genotypes and subtypes were determined by sequencing in the 5'-untranslated region (UTR) viral genomic region and the INNO-LiPA HCVII genotyping kit. Genetic relatedness between HCV strains was assessed by sequencing of a portion of the NS5B region. HCV prevalence was significantly higher in the North-Western region than in the Southern one: 1.7% versus 0.2% (P < 10(-3), chi(2) = 8,506). There was no difference in positivity according to gender or living in rural or urban settings; the only significant risk factor was advanced age. HCV prevalence among household contacts of HCV positives was not significantly higher than the prevalence in the whole study population. These results indicate a heterogeneity in the geographical distribution of HCV in Tunisia. An increased HCV transmission occurs in the North-Western region with large predominance of genotype 1b (88%) and low contribution of intrafamilial transmission.

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Section: Discussionsupporting

confidence: 51%

Contrasting patterns of hepatitis C virus infection in two regions from Tunisia

Mejri

Salah

Triki

et al. 2005

Journal of Medical Virology

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Dépistage et confirmation des anticorps anti-VHC chez les donneurs de sang tunisiens

Abid

Fkih

et al. 1997

Transfusion Clinique et Biologique

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Exposure to hepatitis B and C and to HTLV‐1 and 2 among Israeli drug abusers in Jerusalem

et al. 1994

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The incidence of exposure to hepatitis B (HBV) and C (HCV) viruses and to that of HTLV 1 and 2 were investigated in a group of 181 illicit drug users attending a drug rehabilitation centre in Jerusalem. In this predominantly male group, 28% were intravenous drug abusers (IVDAs) and 72% non-IVDAs; 92% of the individuals were of Middle Eastern descent (of which 40% were of a Moroccan descent). Antibodies to hepatitis C virus (anti-HCV) were found in 54% of the IVDAs compared with 4.5% in the non-IVDAs (p < 0.001), indicating the presence of a significant reservoir of HCV among this IVDA group. Evidence for previous hepatitis B (HBV) infection was found in 26% of the IVDAs and 33% of the non-IVDAs (p = NS) with no HbSAg positivity. The similar prevalence of previous HBV infection in both drug abuser groups, which was also observed when the groups were analysed according to their ethnic origin, suggests that a vertical transmission of HBV rather than an exclusive association with intravenous drug abuse may have been the source of exposure to HBV. HTLV-1 rates were 2% among IVDAs and 0% among non-IVDAs (p = NS). No serologic evidence for HTLV-2 was detected in this cohort. The present study supports previous observations in other countries and indicates the exceptionally high prevalence of HCV infection among Israeli i.v. drug abusers. It also suggests that using HBV seropositivity as an indicator for needle exchange among drug abusers may be of limited value in geographic areas where vertical transmission of HBV is common. HCV antibodies might become more suitable markers for this purpose.

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Etude épidémiologique des anticorps anti-HCV chez les donneurs de sang en Tunisie

Cited by 5 publications

References 13 publications

Contrasting patterns of hepatitis C virus infection in two regions from Tunisia

Contrasting patterns of hepatitis C virus infection in two regions from Tunisia

Dépistage et confirmation des anticorps anti-VHC chez les donneurs de sang tunisiens

Exposure to hepatitis B and C and to HTLV‐1 and 2 among Israeli drug abusers in Jerusalem

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