Étude des Hernandiacées. XII. Dimères aporphine–benzylisoquinoléine originaux isolés de Hernandiapeltata

Abstract

Office de la recherche scientifique et technique d'outre-mer, B.P. 76,

Alkaloidal Content of Four Berberis Species. Structure of Berberilaurine, a New Bisbenzyltetrahydroisoquinoline

“…The chemical differences between the two specimens may be due to different edaphic conditions or different physiological stages at collection time, or may be genetically fixed. Such variations in alkaloid content have already been observed in Hemandia peltata (9,10) and in Albertisia papuana (11,12). This fact leads one to be cautious about the taxonomic significance of the occurrence of particular compounds.…”

Evaluation of an ethnomedicinal combination containingSemecarpus kurziiandHernandia peltataused for the management of inflammation

“…The contemporary literature revealed that the Malaysian species of H. peltata Meisn, used by the Samoan healers, has anti-hypertensive (Dittmar, 1991;Singh, 1986), antitumor (Pernet, 1971), piscicide (Nishino & Mitsui, 1973) and antiarteriosclerosis (Ebel & Roth, 1987) activity. H. peltata from Malaysia is reported to contain benzylisoquinoline alkaloid hebridamine (Chalandre et al, 1986) that inhibit chloroquine-resistant Plasmodium falciparum (Angerhofer et al, 1999), and artherosclerosis (Lakshmi et al, 2009). Moreover, the lignans such as podophyllotoxins (deoxypodophyllotoxin and deoxypicropodophyllin) isolated from H. peltata have anticancer activity (Pettit et al, 2004) while hernanol, benzopyran, epiaschantin and deoxypodorhizone inhibit Neisseria gonorrhoeae (Pettit et al, 2004).…”

8-, 9-, and 11-Aryloxy Dimeric Aporphines and Their Pharmacological Activities

“…Three 2 -or 6-noraporphine-benzylisoquinoline dimers 83-85 are listed in Table 8. Additionally, (+)-thalicarpine-2 -N-oxide (86), the only member of the thalicarpine type with a 2 -N-oxide functional group that was isolated from Hernandia peltate [110], is depicted in Figure 7. In addition, three 6a,7-dehydroaporphine-benzylisoquinoline dimers 87-89 are displayed in Table 9.…”