Etude de l’association du polymorphisme SNP19 du gène calpaïne 10 avec le diabète de type 2 chez deux groupes ethniques dans la population tunisienne : interaction gène-environnement

Ouederni, Thouraya Baroudi; Sánchez‐Corona, José; Skhiri, Hajer; Maı̈z, H. Ben; Abid, Haisam; Benammar-Elgaaïed, Amel

doi:10.1684/abc.2009.0312

Cited by 2 publications

(1 citation statement)

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“…Previous studies implicated UCSNP-19 with altered insulin sensitivity (HOMA-IR index) in Northern European [17] and Spanish [23], but not Scandinavian [15] or Finnish [7] subjects. Our findings were in agreement with a recent small study in Southern Tunisia (Djerba Island) involving 162 T2D patients and 110 control subjects of mixed Arab and non-Arab (Berber) ancestry, in which UCSNP-19 was associated with T2D only in the Arab sub-group [24], and in apparent disagreement with another study in Central Tunisia (Sfax), in which UCSNP-43, but not UCSNP-19, was over-represented in T2D patients [25]. While explanations for the discrepancies remain to be seen, they most likely reside in inadequate statistical power in the study of Kifagi (226 patients and 206 controls), and in differences in subjects' selection (gender distribution, duration of diabetes, BMI status), which in turn may have overestimated the association of UCSNP-43 with T2D.…”

Section: Discussionsupporting

confidence: 93%

Common polymorphisms of calpain-10 and the risk of Type 2 Diabetes in a Tunisian Arab population: a case-control study

et al. 2010

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BackgroundGenetic variations in the calpain-10 gene (CAPN10), in particular the at-risk diplotype (112/121), were previously implicated with increased risk of type 2 diabetes (T2D).MethodsWe examined the association of CAPN10 UCSNP-43 (rs3792267), UCSNP-19 (rs3842570), and UCSNP-63 (rs5030952) SNPs with T2D in 917 Tunisian T2D patients and 748 non-diabetic controls. CAPN10 genotyping was done by PCR-RFLP.ResultsEnrichment of UCSNP-19 2R (minor) allele and 2R/2R genotype was found in T2D patients; the allele and genotype distribution of UCSNP-43 and UCSNP-63 alleles and genotypes were not significantly different between patient groups and non-diabetic control subjects. Regression analysis demonstrated progressive increases in T2D risk in 3R/2R [OR (95% CI) = 1.35 (1.08 - 1.68)] and 2R/2R [OR (95% CI) = 1.61 (1.20 - 2.18)] genotypes. Of the six haplotypes detected, enrichment of haplotype 111 (UCSNP-43/UCSNP-19/UCSNP-63) was seen in patients (Pc = 0.034); the distribution of the other haplotypes was comparable between patients and control subjects; neither haplotype 211 nor haplotype 212 was observed. Furthermore, the frequency of all CAPN10 diplotypes identified, including the "high-risk diplotype (112/121) reported for Mexican-Americans and Northern Europeans, were comparable between patients and controls.ConclusionsCAPN10 UCSNP-19 variant, and the 111 haplotype contribute to the risk of T2D in Tunisian subjects; no significant associations between CAPN10 diplotypes and T2D were demonstrated for Tunisians.

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