In the era of big data, SQL databases face significant challenges in handling vast volumes of data efficiently. This article explores optimization techniques and best practices for enhancing the performance and scalability of SQL databases in handling big data workloads. The study addresses the significant challenges faced by traditional SQL databases, including scalability issues, performance bottlenecks, resource constraints, and data integration complexities. Through a comprehensive methodology involving literature review, case studies, expert interviews, and performance testing, the research identifies effective strategies such as indexing, partitioning, sharding, and caching. Findings from case studies in e-commerce and financial services sectors demonstrate substantial improvements in query performance and resource utilization, validating the practical benefits of these optimization techniques. The study underscores the importance of a multifaceted approach to database optimization, integrating both theoretical and practical insights to address the complexities of big data environments. By staying informed and adopting the latest optimization strategies, database administrators and IT professionals can ensure their SQL databases remain efficient, scalable, and capable of managing the increasing demands of large-scale data processing, ultimately enabling organizations to derive valuable insights from their data.