Ets1 regulates production of dendritic epidermal T cells (DETC) and cooperates with IL17Ra signaling to regulate immune responses to Staphylococcal skin infection
Abstract:Ets1 is a lineage-specific transcription factor regulating lymphocyte differentiation. Mice that lack Ets1 (Ets1 KO) develop autoimmune disease with enhanced B and T cell activation, including increased production of IL-17. To determine if IL-17 contributes to autoimmunity, we crossed Ets1 KO mice to mice lacking the IL17 receptor A subunit (IL17RA KO) to generate double knock out (DKO) mice. We found that loss of IL17RA did not prevent or ameliorate autoimmunity, but that DKO animals exhibited worse symptoms.… Show more
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