ETS1-activated SNHG10 exerts oncogenic functions in glioma via targeting miR-532-3p/FBXL19 axis

Jin, Lide; Huang, Shu‐Zhen; Guan, Congjin; Chang, Shang‐Tzen

doi:10.1186/s12935-020-01649-2

Cited by 17 publications

(14 citation statements)

References 35 publications

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“…miR-532-3p was predicted as a target miRNA of circNRIP1, which was confirmed by dual-luciferase reporter assays. Of note, miR-532-3p has been recognized as a tumor suppressor gene in several types of human cancer ( 30 – 32 ). Analysis of the TCGA dataset and in vitro results of the present study indicated that miR-532-3p was significantly downregulated in CRC tumor tissues and cell lines.…”

Section: Discussionmentioning

confidence: 99%

Knockdown of circNRIP1 sensitizes colorectal cancer to 5‑FU via sponging miR‑532‑3p

Liu

Zhang

et al. 2021

Oncol Rep

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The present study aimed to investigate the influence of circular RNA nuclear receptor-interacting protein 1 (circNRIP1) on the chemotherapeutic effect of 5-fluorouracil (5-FU) in colorectal cancer (CRC) and reveal its potential molecular mechanisms. The effects of circNRIP1 on cell proliferation, migration and invasion, and apoptosis were evaluated using Cell Counting Kit-8, Transwell and flow cytometric assays, respectively. A dual-luciferase reporter assay was performed to verify the potential interaction between circNRIP1 and microRNA (miR)-532-3p. The results of the present study indicated that circNRIP1 was upregulated in CRC and its increased expression was associated with CRC progression. Furthermore, overexpression of circNRIP1 promoted CRC cell proliferation, invasion and migration, while it inhibited apoptosis. Knockdown of circNRIP1 significantly enhanced the 5-FU-induced inhibition of the viability of HCT116 and SW480 cells. Bioinformatics analysis predicted that miR-532-3p was a direct target of circNRIP1, which was further confirmed by a dual-luciferase reporter assay. miR-532-3p silencing reversed the effects of circNRIP1 knockdown on the sensitivity of 5-FU in the chemotherapy of CRC. The results suggested that circNRIP1 and miR-532-3p may be utilized to improve the diagnosis of CRC and serve as diagnostic markers. In conclusion, overexpression of circNRIP1 promoted the progression of CRC, while circNRIP1 silencing sensitized CRC cells to 5-FU via sponging miR-532-3p.

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Section: Discussionmentioning

confidence: 99%

Knockdown of circNRIP1 sensitizes colorectal cancer to 5‑FU via sponging miR‑532‑3p

Liu

Zhang

et al. 2021

Oncol Rep

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“…Increasing evidence suggests that lncRNAs could play as trans regulators scaffolds [ 7 ] or microRNAs sponges [ 8 ]. LncRNA SNHG10 has been reported dual-faced effects on cancer progress via different microRNAs in different human tumor [ 18 , 37 , 39 ]. SNHG10 was reported as oncogenic functions in glioma via targeting miR-532-3p/FBXL19 axis [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…LncRNA SNHG10 has been reported dual-faced effects on cancer progress via different microRNAs in different human tumor [ 18 , 37 , 39 ]. SNHG10 was reported as oncogenic functions in glioma via targeting miR-532-3p/FBXL19 axis [ 39 ]. Meanwhile, in non-small cell lung cancer, SNHG10 was reported suppress cancer cell proliferation by upregulating tumor suppressive SIRT1 as miR-543 sponge [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA SNHG10 promotes colorectal cancer cells malignant progression by targeting miR-3690

et al. 2021

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Long noncoding RNA small nucleolar RNA host gene 10 (SNHG10) has been suggested to function as tumor promoter in various human cancer types. Herein, the role of SNHG10 in colorectal cancer (CRC) was explored. Expression levels of genes in colorectal cancer tissues and cell lines were detected by Starbase and reverse transcription quantitative PCR (RT-qPCR) Cell Counting Kit-8 (CCK-8), the BrdU incorporation assay and Transwell assays were explored to study the function of SNHG10 in HCT116 and DXH-1 cells. In addition, the interaction of SNHG10 and miR-3690 was analyzed by dual-luciferase reporter assays. SNHG10 had a high expression level in CRC tissues and cell lines. Meanwhile, knockdown of SNHG10 reduced cell viability, inhibited cell proliferation and decreased cell migration and invasion. Moreover, bioinformatics analysis revealed that one potential target gene of SNHG10 was miR-3690. Dual-luciferase reporter assay confirmed that miR-3690 directly targeted SNHG10. Importantly, SNHG10 could decrease the expression of miR-3690 in HCT116 and DXH-1 cells. More importantly, the silencing of miR-3690 reversed the effect of the SNHG10 knockdown on the cell viability, proliferation, migration and invasion of HCT116 and DXH-1 cells. The present results demonstrated that SNHG10 promotes colorectal cancer cells the malignant progression by targeting miR-3690.

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“…Aberrant expression of SNHG10 has been elucidated in various human cancers. For example, SNHG10 exerted oncogenic functions in glioma by sponging miR-532-3p and enhancing FBXL19 expression ( Jin et al, 2020 ). In addition, SNHG10 has reported to promote cell proliferation in osteosarcoma via increasing glucose uptake and miR-218 gene methylation ( He et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

SNHG10 Is a Prognostic Biomarker Correlated With Immune Infiltrates in Prostate Cancer

Chen

Yang

Gong

et al. 2021

Front. Cell Dev. Biol.

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SNHG10 is a long non-coding RNA (lncRNA) found to be overexpressed in multiple human cancers including prostate cancer (PC). However, the underlying mechanisms of SNHG10 driving the progression of PC remains unclear. In this study, we investigated the role of SNHG10 in PC and found that SNHG10 expression was significantly increased in datasets extracted from The Cancer Genome Atlas. Increased expression of SNHG10 was related to advanced clinical parameters. Receiver operating curve analysis revealed the significant diagnostic ability of SNHG10 (AUC = 0.805). In addition, immune infiltration analysis, and GSEA showed that SNHG10 expression was correlated with oxidative phosphorylation and immune infiltrated cells. Finally, we determined that SNHG10 regulated cell proliferation, migration, and invasion of PC in vitro. In conclusion, our data demonstrated that SNHG10 was correlated with progression and immune infiltration, and could serve as a prognostic biomarker for PC.

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ETS1-activated SNHG10 exerts oncogenic functions in glioma via targeting miR-532-3p/FBXL19 axis

Cited by 17 publications

References 35 publications

Knockdown of circNRIP1 sensitizes colorectal cancer to 5‑FU via sponging miR‑532‑3p

Knockdown of circNRIP1 sensitizes colorectal cancer to 5‑FU via sponging miR‑532‑3p

Long noncoding RNA SNHG10 promotes colorectal cancer cells malignant progression by targeting miR-3690

SNHG10 Is a Prognostic Biomarker Correlated With Immune Infiltrates in Prostate Cancer

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