Ets-1 Proto-Oncogene as a Potential Predictor for Poor Prognosis of Lung Adenocarcinoma

Abstract

The protooncogene Ets-1 is a transcription factor that is known to regulate certain matrix metalloproteinases and plasminogen activator, which have been associated with malignant behaviors in solid carcinomas. We hypothesized that Ets-1 expression is also associated with tumor progression and a worse prognosis in lung carcinoma patients. To clarify the role of the Ets-1 proto-oncogene, the expression of Ets-1 in non-small cell lung carcinomas using 156 paraffin-embedded specimens was determined in surgically resected tissue samples. Immunohistochemical staining showed Ets-1 expression in 82 cases of 156 carcinomas (53%): 36 of 52 (69%) squamous cell carcinomas, 41 of 96 (43%) adenocarcinomas, and 5 of 8 (63%) other carcinomas. In adenocarcinomas, a higher proportion of acinar type expressed Ets-1 compared to papillary or alveolar type ( p < 0.05). The proportion of adenocarcinoma that expressed Ets-1 increased with poorer histologic differentiation of the adenocarcinoma ( p < 0.05). Ets-1 positive adenocarcinomas had a larger mean size than Ets-1 negative adenocarcinomas ( p < 0.01). In adenocarcinoma patients, expression of Ets-1 was associated with disease-free ( p = 0.09) and overall survivals ( p < 0.05) after lung resection. Such relationship was not observed among squamous cell carcinoma patients. Our findings indicate that Ets-1 expression is related to histopathological differentiation, morphogenesis, and tumor progression of lung adenocarcinomas. Ets-1 appears to be a useful predictor of poor prognosis after surgical resection in lung adenocarcinoma patients. Ets-1 expression could be used to evaluate the malignant behaviors of lung adenocarcinomas.Ets-1; non-small cell lung cancer; histologic differentiation; subtype; prognosis

Immunohistochemical Determination of ETS-1 Oncoprotein Expression in Urothelial Carcinomas of the Urinary Bladder

“…7,8,26 ETS-1 is thought to be related to the growth of carcinoma cells by its regulation of the transcription of MMPsFMMP1, MMP3, MMP9 and uPA [6][7][8][9]18 ; these proteases are responsible for ECM degradation, which is a key event in invasion. 27 It induces endothelial cell proliferation and activation, which in turn results in angiogenesis, another potential mechanism of action for this protooncogene.…”

The transforming growth factor beta-1 in the oncogenesis of human lung adenocarcinoma

“…Белок ETS1 контролирует уровни экспрессии множества ге-нов, включая факторы транскрипции, протеазы, гены клеточного цикла, гены, регулирующие апоптоз, цито-кины и факторы роста [32]. Повышенная активность ETS1 наблюдалась при РМЖ, РЛ, раке яичников, обо-дочной и прямой кишки и меланоме [33][34][35][36][37]. ETS1 сверхэкспрессируется при инвазивном РМЖ и корре-лирует с его плохим прогнозом [38].…”

Gambogic acid-loaded magnetic Fe3O4 nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1

“…30 Aberrant ETS1 expression appears to be associated with the pathophysiology of some malignancies, [5][6][7][8][9] so it has been suggested that pharmacological inhibition of ETS1 transcriptional activity may prove useful as a novel anticancer strategy. Recent reports have suggested transcriptional silencing of ETS1 could efficiently suppress angiogenesis in pancreatic cancer.…”

“…4 ETS1 plays a role in the regulation of physiologic processes such as cell proliferation and differentiation, and there is much evidence suggesting important roles for ETS1 in carcinogenesis and progression of a wide range of malignancies, including pancreatic cancer. [5][6][7][8][9] Transcriptional silencing of ETS1 could suppress angiogenesis of pancreatic cancer efficiently. 10 Correlation between ETS1 overexpression and aggressive tumor behavior suggests that ETS1 may be an attractive molecular target for cancer therapy.…”