Etomidate Reversibly Depresses Human Neutrophil Chemiluminescence

Gelb, Adrian W.; Lok, Peter

doi:10.1097/00000542-198701000-00011

Cited by 23 publications

(9 citation statements)

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“…By contrast, it is not known whether the thiopental tissue concentrations are also so high at the site of infection or injury as to inhibit granulocyte chemiluminescence responses. The decreases in chemiluminescence responses can be expected to be similarly reversiblr to such decreases due to etomidate (30). Our finding of increased chemiluminescence in unstimulated measurements at a thiopental concentration of 25 pg/ml is in accordance with an earlier study which found enhanced oxygen consumption by unstimulated granulocytes in the presence of the above thiopental concentrations (36).…”

Section: Discussionsupporting

confidence: 92%

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Effects of thiopental on granulocyte oxidative microbicidal capacity

Salo

Perttilä

1989

Acta Anaesthesiol Scand

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Some anaesthetics are known to depress granulocyte chemiluminescence responses in the phagocytosis of zymosan as a measure of their oxidative microbicidal capacity. In this study the effects of thiopental were measured on chemiluminescence responses in the phagocytosis of Staphylococcus aureus and Escherichia coli, which are the commonest bacteria causing postoperative infections. Granulocytes from 14 healthy volunteers (mean age 35 +/- 9 (s.d.) years) were tested in vitro in the presence of clinical thiopental concentrations 0, 5, 10 and 25 micrograms/ml (0, 18, 36 and 91 mumol/l, respectively). During a 60-min exposure period, decreased chemiluminescence responses occurred to Staph. aureus at 5 micrograms/ml (P less than 0.01) and higher thiopental concentrations and to E. coli at 10 micrograms/ml (P less than 0.01) and higher concentrations, as a sign of depressed oxidative microbicidal activity.

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Section: Discussionsupporting

confidence: 92%

“…The responses were measured in the phagocytosis of Staph. aureus and E. coli in contrast to some other studies which have measured responses to zymosan, a suspension of yeast particles (22,23,29,30). A ratio of 100 bacteria to one granulocyte was used to obtain supramaximal stimulus.…”

Section: Discussionmentioning

confidence: 99%

Effects of thiopental on granulocyte oxidative microbicidal capacity

Salo

Perttilä

1989

Acta Anaesthesiol Scand

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“…In previous in-vitro and in-vivo studies, the immunomodulatory effects of anaesthetics, especially on PMN function, have been extensively described [1,[5][6][7][8]. Several investigators have found an in-vitro decrease in PMN free radical production [9,10] and a decrease in phagocytosis in vitro [11,12] and in vivo [13][14][15] in peripheral blood. Other studies have not confirmed these changes in PMN functional variables [16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Effects of desflurane, sevoflurane and propofol on phagocytosis and respiratory burst activity of human polymorphonuclear leucocytes in bronchoalveolar lavage

Erol

Reisli²,

Reisli³

et al. 2009

European Journal of Anaesthesiology

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“…However, it does not affect chemotaxis [22,24]. It is not clear whether etomidate inhibits the respiratory burst [25] or not [26].…”

Section: Discussionmentioning

confidence: 99%

The influence of intravenous anaesthetics on the activity of enzymes released from polymorphonuclear leucocytes in vitro

Krumholz

Weidenbusch

Menges

et al. 2001

European Journal of Anaesthesiology

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Background and objective Polymorphonuclear leucocytes make a decisive contribution to defence against bacterial infections. In particular, the effects of anaesthetics on non-oxidative bactericidal mechanisms have previously only been super®cially examined. Although the in¯uence of anaesthetic agents on oxidative bactericidal activity has been thoroughly examined, our study concentrated on the effect on nonoxidative processes, which appears to have been a neglected ®eld of research. Methods The effects of methohexital, etomidate, ketamine, fentanyl and morphine on the activity of lysozyme and b-glucuronidase released from polymorphonuclear leucocytes have been studied in vitro. The activity of lysozyme was determined by recording the changes in the turbidity of a suspension of micrococcus lysodeicticus caused by the enzymatic action of lysozyme. b-glucuronidase activity was photometrically measured by the enzymatic cleavage of phenolphthalein glucuronic acid. Results High concentrations of methohexital inhibited lysozyme activity; however, etomidate and morphine caused an increase of b-glucuronidase activity in therapeutic plasma concentrations. While there was no effect of etomidate on lysozyme activity, all concentrations tested signi®cantly stimulated

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Etomidate Reversibly Depresses Human Neutrophil Chemiluminescence

Cited by 23 publications

References 0 publications

Effects of thiopental on granulocyte oxidative microbicidal capacity

Effects of thiopental on granulocyte oxidative microbicidal capacity

Effects of desflurane, sevoflurane and propofol on phagocytosis and respiratory burst activity of human polymorphonuclear leucocytes in bronchoalveolar lavage

The influence of intravenous anaesthetics on the activity of enzymes released from polymorphonuclear leucocytes in vitro

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