Etiopathogenesis of Psoriasis: Integration of Proposed Theories

Hernandez-Nicols, Brenda Fernanda; Robledo-Pulido, Juan José; Alvarado-Navarro, Anabell

doi:10.1080/08820139.2024.2302823

Cited by 8 publications

(12 citation statements)

References 491 publications

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“…Therefore, clinical manifestations of psoriasis are very diverse and may vary in individual patients during the course of the disease [28]. The etiopathogenesis of this disease is based on the interaction of autoimmune and autoinflammatory mechanisms, dysbiosis of skin microbiota, and oxidative stress combined with a strong genetic predisposition [29]. The underlying inflammatory processes involve and affect all immune cell populations that inhabit and infiltrate the patient's skin, and also trigger a systemic inflammatory response, leading to the development of serious complications and comorbidities.…”

Section: Mouse Models Of Psoriasismentioning

confidence: 99%

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Nazimek,

Bryniarski

2024

IJMS

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Psoriasis is a systemic autoimmune/autoinflammatory disease that can be well studied in established mouse models. Skin-resident macrophages are classified into epidermal Langerhans cells and dermal macrophages and are involved in innate immunity, orchestration of adaptive immunity, and maintenance of tissue homeostasis due to their ability to constantly shift their phenotype and adapt to the current microenvironment. Consequently, both macrophage populations play dual roles in psoriasis. In some circumstances, pro-inflammatory activated macrophages and Langerhans cells trigger psoriatic inflammation, while in other cases their anti-inflammatory stimulation results in amelioration of the disease. These features make macrophages interesting candidates for modern therapeutic strategies. Owing to the significant progress in knowledge, our review article summarizes current achievements and indicates future research directions to better understand the function of macrophages in psoriasis.

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Section: Mouse Models Of Psoriasismentioning

confidence: 99%

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Nazimek,

Bryniarski

2024

IJMS

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“…Psoriasis affects up to 3% of the world's population, women and men equally, with variations in different regions. The disorder has a bimodal age distribution ranging from 18 to 39 years and 50 to 69 years [153].…”

Section: Typical Features and Epidemiology Of Psoriasismentioning

confidence: 99%

“…Importantly, several drugs have been found to aggravate or induce the onset of psoriasis. These agents include beta-blockers, calcium-channel blockers, thiazide diuretics, lithium, anti-malarial drugs, interferons, imiquimod, angiotensin-converting enzyme inhibitors, terbinafine, tetracycline, NSAIDs, and fibrates [153]. Approximately 20% of patients with psoriasis develop psoriatic arthritis, further disfiguring and disabling them.…”

Section: Typical Features and Epidemiology Of Psoriasismentioning

confidence: 99%

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The Role of Alarmins in the Pathogenesis of Rheumatoid Arthritis, Osteoarthritis, and Psoriasis

Kiełbowski,

Stańska,

Bakinowska

et al. 2024

CIMB

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Alarmins are immune-activating factors released after cellular injury or death. By secreting alarmins, cells can interact with immune cells and induce a variety of inflammatory responses. The broad family of alarmins involves several members, such as high-mobility group box 1, S100 proteins, interleukin-33, and heat shock proteins, among others. Studies have found that the concentrations and expression profiles of alarmins are altered in immune-mediated diseases. Furthermore, they are involved in the pathogenesis of inflammatory conditions. The aim of this narrative review is to present the current evidence on the role of alarmins in rheumatoid arthritis, osteoarthritis, and psoriasis. We discuss their potential involvement in mechanisms underlying the progression of these diseases and whether they could become therapeutic targets. Moreover, we summarize the impact of pharmacological agents used in the treatment of these diseases on the expression of alarmins.

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“…From a dermatological point of view, psoriasis mainly presents with scaly, welldemarcated, erythematous plaques and nail dystrophy [5]. However, a significant proportion of psoriasis patients develop joint manifestations at some point in their disease course.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of the JAK-STAT Pathway in the Treatment of Psoriasis: A Review of the Literature

Furtunescu,

Georgescu,

Tampa

et al. 2024

IJMS

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Psoriasis is a highly prevalent dermatological disease associated with an increased systemic inflammatory response. In addition, joint involvement is also present in around 20% of patients. Therefore, treatment modalities used in this condition should be simultaneously effective at improving skin manifestations, reducing inflammation, and addressing psoriatic arthritis when present. Twenty years ago, the introduction of biologic treatments for psoriasis was a turning point in the management of this condition, offering an effective and reasonably safe option for patients whose disease could not be adeqsuately controlled with conventional therapies. At the moment, Janus Kinase inhibitors (JAKis) are a new class of promising molecules in the management of psoriasis. They are orally administered and can show benefits in patients who failed biologic therapy. We conducted a scoping review in order to identify randomized-controlled trials that investigated different JAKis in patients with plaque psoriasis and psoriatic arthritis, with an emphasis on molecules that have been approved by the European Medicines Agency and the Food and Drug Administration. The added value of this study is that it collected information about JAKis approved for two different indications, plaque psoriasis and psoriatic arthritis, in order to provide an integrated understanding of the range of effects that JAKis have on the whole spectrum of psoriasis manifestations.

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Etiopathogenesis of Psoriasis: Integration of Proposed Theories

Cited by 8 publications

References 491 publications

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Macrophage Functions in Psoriasis: Lessons from Mouse Models

The Role of Alarmins in the Pathogenesis of Rheumatoid Arthritis, Osteoarthritis, and Psoriasis

Inhibition of the JAK-STAT Pathway in the Treatment of Psoriasis: A Review of the Literature

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