Etiopathogenesis of periodontitis in children and adolescents

Kinane, Denis F.; Podmore, Michelle; Ebersole, Jeffrey L.

doi:10.1034/j.1600-0757.2001.2260104.x

Cited by 52 publications

(57 citation statements)

References 322 publications

(363 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…18 An inflammatory infiltrate (mainly comprised of neutrophils or polymorphonuclear leukocytes) is usually present, even in the absence of clinically obvious inflammation in order to maintain periodontal homeostasis. 19 The bacteria associated with PD comprise a group of Gram-negative anaerobic organisms, among which the socalled "red complex" pathogens, especially Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, are more prominent. The reasons for the host response fails to control periodontal infection or to inhibit disease progression are not well understood, but the disruption of host homeostasis by periodontal pathogens may be a major contributory factor.…”

Section: Pathogenesis Of Pdmentioning

confidence: 99%

Periodontal disease in pediatric rheumatic diseases

Fabri

Savioli

Siqueira

et al. 2014

Revista Brasileira de Reumatologia (English Edition)

View full text Add to dashboard Cite

Section: Pathogenesis Of Pdmentioning

confidence: 99%

Periodontal disease in pediatric rheumatic diseases

Fabri

Savioli

Siqueira

et al. 2014

Revista Brasileira de Reumatologia (English Edition)

View full text Add to dashboard Cite

“…Increased levels of acute-phase proteins have been identified in adult periodontitis patients and appear to reflect both the infection and the acute and chronic inflammation that exists in the periodontium (18,39,55). At the same time, it is clear that a serum antibody response to these localized infections exists and that it results from specific elicitation of antibody to an infecting microorganism (19,24,40,41,46,79).Periodontal disease has been effectively used as a model of host-bacterium interactions, inflammation, and chronic inflammatory diseases, particularly for the ability to longitudinally describe bacterial and host factors in the oral cavity and to correlate changes in these factors with pathological changes in …”

mentioning

confidence: 96%

Effects of Age and Oral Disease on Systemic Inflammatory and Immune Parameters in Nonhuman Primates

Ebersole

Steffen

González‐Martínez

et al. 2008

Clin Vaccine Immunol

View full text Add to dashboard Cite

This report evaluated systemic inflammatory and immune biomarkers in a cohort of Macaca mulatta (rhesus monkeys) maintained as a large family social unit, including an age range from <1 year to >24 years. We hypothesized that the systemic host responses would be affected by the age, gender, and clinical oral presentation of the population, each contributing to inflammatory and immune responses that would reflect chronic oral infections. The results demonstrated that the prevalence and severity of periodontitis, including missing teeth, increased significantly with age. Generally, minimal differences in clinical parameters were noted between the genders. Systemic inflammatory mediators, including acute-phase reactants, prostaglandin E 2 (PGE 2 ), cytokines/chemokines, and selected matrix metalloproteinases (MMP), demonstrated significant differences among the various age groups of animals. Levels of many of these were increased with age, although PGE 2 , RANTES, bactericidal permeability-inducing factor (BPI), MMP-1, and MMP-9 levels were significantly increased in the young group (ϳ1 to 3 years old) relative to those for the older animals. We observed that in the adult and aged animals, levels of the systemic inflammatory mediators related to gingival inflammation and periodontal tissue destruction were significantly elevated. Serum antibody levels in response to a battery of periodontal pathogens were generally lower in the young animals, <50% of those in the adults, and were significantly related to aging in the cohort. The levels of antibodies, particularly those to Porphorymonas gingivalis, Fusobacterium nucleatum, and Tannerella forsythia, were most significantly elevated in animals with periodontal disease, irrespective of the age of the animal. These results provide a broad description of oral health and host responses in a large cohort of nonhuman primates from very young animals to the aged of this species. The findings afford a base of data with which to examine the ontogeny of host responses at mucosal sites, such as the gingival tissues.Periodontal disease is the predominant chronic inflammatory disease of humanity (37,38,78,82) and has been noted to occur naturally with increasing age in humans and nonhuman primates (36,63,69,88). This oral disease is an outcome of complex oral infections, chronic immunoinflammatory responses, and resulting destruction of soft and hard tissues of the periodontium (37,78,80,82,84). In both humans and nonhuman primates, the extent of disease is predicted to be controlled by the quality and quantity of the host response and likely is modulated by systemic disease (48), environmental stressors (6, 76, 85), and the genetic backgrounds of the individuals (3, 70, 84).The oral microbial characteristics of subgingival biofilms in younger and older individuals demonstrate differences in composition and complexity, which have been suggested to contribute directly to the microbial infections that trigger the destructive disease of oral tissues that occurs during aging (4,35,49,...

show abstract

“…Hence, demonstration of gingival index values which increase during puberty strongly depends on the proper selection of parameters and analytical methods 15,16 . Some authors 17 noticed that all additional factors that could modify the inflammatory response must be eliminated in order to explore the effects of hormone action on gingival health. For these reasons, it is believed that children of teenage group are most adequate, since the concentration of sex hormones and the incidence of gingivitis are increased at that period of life.…”

Section: Discussionmentioning

confidence: 99%

“…Dakle, vrednosti gingivalnih indeksa koje su povećane u pubertetu zavise i od pravilnog izbora parametara i primenjenih analitičkih metoda 15,16 . Neki autori 17 su primetili da svi faktori koji mogu da menjaju zapaljenski odgovor moraju biti eliminisani kako bi se procenilo dejstvo hormona na zdravlje gingive. Iz ovih razloga, veruje se da su tinejdžeri najadekvatnija starosna grupa, jer je koncentracija polnih hormona i učestalost gingivitisa povećana u ovom periodu života.…”

Section: Diskusijaunclassified

The influence of estrogen on the gingival health of girls

Radojkova-Nikolovska¹,

Popovska²,

Minovska³

et al. 2014

Acta stomatologica Naissi

View full text Add to dashboard Cite

Uvod. Inflamacija gingive je veoma česta u detinjstvu i pubertetu. Cilj istraživanja bio je odrediti indekse gingive i vrednosti 17β estradiola u pljuvački i serumu i njegov uticaj na zdravlje gingive kod tinejdžerki. Pacijenti i metode. Studija je obuhvatila 30 devojčica (starosti od 11 do 14 godina) sa inflamacijom gingive i 30 devojčica kontrolne grupe koje nemaju inflamaciju gingive. Stepen zdravlja gingive je procenjen kliničkim merenjem indeksa gingive. Koncentracija 17β estradiola u serumu i pljuvački određena je DRG Estradiol ELISA (EIA-2693) i DRG Salivary Estradiol ELISA (SLV-4188) metodom. Rezultati. Vrednosti indeksa gingive jasno ukazuju na prisustvo inflamacije gingive. Analiza vrednosti nivoa estrogena u serumu i pljuvački ukazuju na pozitivnu korelaciju indeksa, posebno ističući uticaj 17β estradiola na inflamaciju i krvarenje gingive. Zaključak. Dobijene vrednosti koncentracije hormona u serumu i pljuvački pokazuju u obe grupe njegov potencijalni uticaj na zdravlje gingive, što ističe ulogu stomatologa u preventivi i terapiji parodontopatije u pubertetu. Conclusion.The obtained values of the hormone concentrations in serum and saliva, in both groups, suggest their potential impact on the gingival health. This emphasizes the role of dentists in preventive and treatment modalities in patients during the period of puberty.

show abstract

Etiopathogenesis of periodontitis in children and adolescents

Cited by 52 publications

References 322 publications

Periodontal disease in pediatric rheumatic diseases

Periodontal disease in pediatric rheumatic diseases

Effects of Age and Oral Disease on Systemic Inflammatory and Immune Parameters in Nonhuman Primates

The influence of estrogen on the gingival health of girls

Contact Info

Product

Resources

About