Etiology of Urolithiasis

Al-Mamari, Said Abdallah

doi:10.1007/978-3-319-62437-2_6

Cited by 2 publications

(2 citation statements)

References 140 publications

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“…Citrate is a weak organic acid that gets reabsorbed into the system to avoid metabolic acidosis in hyperoxaluric rats, resulted in hypocitraturia. On the other hand, the magnesium ions provide alkalinity in urine to avoid supersaturation by competing with calcium ions in crystal formation, as the magnesium crystals are highly soluble in water 33,34 . However, the supplementation of pAA and vitamin E (Individual and in combination), found to have significantly increased the excretion of these ions, leading to interference in the stone formation and disease progression.…”

Section: Resultsmentioning

confidence: 99%

Combined effect of polyacrylic acid and vitamin E in preventing calcium oxalate crystal deposition in the kidneys of experimental hyperoxaluric rats

Sridharan

Jagannathan

Ganesh

et al. 2022

Cell Biochemistry & Function

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Our study explores the combined effect of polyacrylic acid and vitamin E as prophylactic and curative agent against ethylene glycol (EG) induced calcium oxalate stone formation in Wistar rats. Male Wistar rats (54) were divided into nine groups, including control. The experimental groups were equally segregated into two for preventive study (4) and curative study (4). Urolithiasis was induced with 0.75% (v/v) EG in drinking water. Polyacrylic acid (10 mg/kg) and vitamin E (300 IU/day) were supplemented from day 1 for preventive and day 30 for curative studies. Restoration of urinary lithogenic factors (calcium, oxalate, phosphate, citrate and magnesium) and renal function (urea and creatinine in serum) by intervening agents were accomplished compared to urolithic rats (P < .001). Abnormal localization and increased expression of Tamm–Horsfall Protein, osteopontin and transferrin were observed in the kidneys of urolithic rats (P < .001) from immunohistochemistry and immunoblotting analysis. Polyacrylic acid and vitamin E supplementation have regulated the expression of the urinary macromolecules. Pro‐inflammatory cytokines in kidney were significantly reduced (P < .001) by the intervening agents compared to urolithic rats. Therefore, polyacrylic acid and vitamin E in combination could be a potential formulation for better management of urolithiasis.

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Section: Resultsmentioning

confidence: 99%

Combined effect of polyacrylic acid and vitamin E in preventing calcium oxalate crystal deposition in the kidneys of experimental hyperoxaluric rats

Sridharan

Jagannathan

Ganesh

et al. 2022

Cell Biochemistry & Function

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show abstract

“…A population-based study published in 2022 states the prevalence of urolithiasis as 7, 5–10, 8.8 and 5.7 percent in China, Europe, North America and Iran, respectively 3 . Diet, genetic predisposition, dysmetabolism, environmental factors, xenobiotics, individual medical history, and high salt intake are the causative factors for the urolithiasis 4 . Clinically, individuals with urolithiasis present persistent low back pain or vague stomachache accompanied by nausea and vomiting.…”

Section: Introductionmentioning

confidence: 99%

In silico docking and Molecular Dynamic (MD) simulations studies of selected phytochemicals against Human Glycolate Oxidase (hGOX) and Oxalate oxidase (OxO)

Nageswari,

Swathi

2023

Drug Res (Stuttg)

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Globally, Urolithiasis is the most prevalent urological problem which affects the populations across the ages and races. In recent years, several phytochemicals are being investigated to improve the efficacy and safety of anti-urolithiasis formulations. To develop drugs based on traditional medicines, it is essential to understand the molecular mechanism of action of these drugs. We present the results of in silico docking and molecular dynamic (MD) simulation studies on selected phytochemical including catechin, epicatechin, gallic acid, gallocatechin, epigallocatechin, epigallocatechin 3-o-gallate, 4-methoxy-nor-securine, nor-securinine, and fisetin with human glycolate oxidase (hGOX) and oxalate oxidase (OxO). Gallic acid, gallocatechin and fisetin showed better docking scores than the rest. In MD simulation analysis, stable interactions of the gallic acid with hGOX and OxO; gallocatechin and fisetin with hGOX were observed. It was found that, gallic acid stably interacts withTYR26, LYS 236, ARG 315, and ASP 291 residues of hGOX. On other hand, gallic acid stably interacs with GLU 58 residue of OxO. Gallocatechin, forms stable interactions with TYR 26, ASP 170, ARG 167 and THR 161 of HGOX. In MD simulations, fisetin stably interacted with TYR 26, TRP110 and ARG 263 as we predicted in molecular docking. None of the interactions was formed during the MD simulation of OxO with gallocatechin and fisetin. Together, these results suggest that gallic acid, gallocatechin and fisetin are the potential candidates for the development of phytochemicals for the management of urolithiasis in humans.

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Etiology of Urolithiasis

Cited by 2 publications

References 140 publications

Combined effect of polyacrylic acid and vitamin E in preventing calcium oxalate crystal deposition in the kidneys of experimental hyperoxaluric rats

Combined effect of polyacrylic acid and vitamin E in preventing calcium oxalate crystal deposition in the kidneys of experimental hyperoxaluric rats

In silico docking and Molecular Dynamic (MD) simulations studies of selected phytochemicals against Human Glycolate Oxidase (hGOX) and Oxalate oxidase (OxO)

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