Etiology of sperm immunity in women

Clarke, Gary N.

doi:10.1016/j.fertnstert.2007.11.045

Cited by 34 publications

(19 citation statements)

References 32 publications

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“…In addition, corroborating the potential importance of previous exposure to heterospecific sperm, recent work in nonhybridizing passerine species and populations shows no evidence of cryptic female discrimination against heterospecific sperm (Cramer et al 2014(Cramer et al , 2016. Mechanistically, we suggest that this plastic response by females could be related to the immune system, as female immune responses to sperm are known in a number of taxa, including humans (Clarke 2009;Morrow and Innocenti 2012), and birds artificially inseminated with heterospecific sperm (Haley and Abplanalp 1970). Moreover, differences in the antigenicity of sperm surface proteins have been implicated in the reduced ability of turkey (Meleagris gallopavo) sperm to cross chicken (Gallus domesticus) vaginas following artificial insemination Wishart 1992, 1996).…”

Section: Discussionsupporting

confidence: 84%

“…, ). Mechanistically, we suggest that this plastic response by females could be related to the immune system, as female immune responses to sperm are known in a number of taxa, including humans (Clarke ; Morrow and Innocenti ), and birds artificially inseminated with heterospecific sperm (Haley and Abplanalp ). Moreover, differences in the antigenicity of sperm surface proteins have been implicated in the reduced ability of turkey ( Meleagris gallopavo ) sperm to cross chicken ( Gallus domesticus ) vaginas following artificial insemination (Steele and Wishart , ).…”

Section: Discussionmentioning

confidence: 93%

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Females discriminate against heterospecific sperm in a natural hybrid zone

et al. 2016

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When hybridization is maladaptive, species-specific mate preferences are selectively favored, but low mate availability may constrain species-assortative pairing. Females paired to heterospecifics may then benefit by copulating with multiple males and subsequently favoring sperm of conspecifics. Whether such mechanisms for biasing paternity toward conspecifics act as important reproductive barriers in socially monogamous vertebrate species remains to be determined. We use a combination of long-term breeding records from a natural hybrid zone between collared and pied flycatchers (Ficedula albicollis and F. hypoleuca), and an in vitro experiment comparing conspecific and heterospecific sperm performance in female reproductive tract fluid, to evaluate the potential significance of female cryptic choice. We show that the females most at risk of hybridizing (pied flycatchers) frequently copulate with multiple males and are able to inhibit heterospecific sperm performance. The negative effect on heterospecific sperm performance was strongest in pied flycatcher females that were most likely to have been previously exposed to collared flycatcher sperm. We thus demonstrate that a reproductive barrier acts after copulation but before fertilization in a socially monogamous vertebrate. While the evolutionary history of this barrier is unknown, our results imply that there is opportunity for it to be accentuated via a reinforcement-like process.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 93%

Females discriminate against heterospecific sperm in a natural hybrid zone

et al. 2016

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“…These and the Western blot results led us to conclude that the raised antibodies specifically associated with sperm mkCRISP1 can interfere with sperm function, as previously observed (14,15,20). The interaction of anti-hCRISP1 antibodies with sperm within the male reproductive tract suggests that a similar mechanism could also occur in females, where the antibodies have even easier access to sperm due to the open nature of their reproductive tract (34,35).…”

Section: Figuresupporting

confidence: 70%

Immunologic behavior of human cysteine-rich secretory protein 1 (hCRISP1) in primates: prospects for immunocontraception

Ellerman

Cohen

Muñoz

et al. 2010

Fertility and Sterility

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“…This mechanism is not yet entirely clear and is subject to further investigation (2). Other mechanisms are the cross-reactivity mechanism with microbial antigens and that of potentiating the immune response with interferon gamma (production of anti-idiotype antibodies) in women whose male partners have anti-sperm antibodies in the semen (3).…”

Section: Anti-sperm Antibodies (Asa): Allo-antibodies Against Spermmentioning

confidence: 99%

Incidence of antibodies in women after failure of assisted reproduction

Bobak

Bobakova²,

Vaczy³

et al. 2014

BLL

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Abstract:Objectives: The aim of this study is to determine to what degree antisperm allo-antibodies (ASA), anti-ovarian antibodies (AOA), anti-zona pellucida antibodies (AZPA) and seven anti-phospholipid antibodies (APLA) can explain the failure of assisted reproduction technology (ART) in women. Background: Among the causes of reproductive failure are allo-and autoimmune reactions of the organism against reproductive tissues and cells. Methods: We examined a sample of 43 selected women aged 27 to 45 after failure of assisted reproduction technology (ART) via intrauterine insemination (IUI), in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Sera from these women were tested by ELISA (enzyme-linked immunosorbent assay) (total Ig) for the presence of anti-sperm allo-antibodies (ASA), anti-ovarian antibodies (AOA), anti-zona pellucida antibodies (AZPA) and seven anti-phospholipid antibodies (APLA). Results: We found 22 (51 %) patients positive for the examined antibodies. Among patients with positive results were 3 miscarriages, 3 biochemical pregnancies (↑ hCG) and 16 with no evidence of conception. Positive APLA was found in 17 patients. Selected immunological parameters were negative in 21 (49 %) patients, which means that the tested allo-and auto-antibodies did not cause the failure of ART. Conclusion: This demonstrates that the range of diagnostic tests limits the success of diagnosis and the method of dealing with infertile couples. The use of cardiolipin as a screening test appears to be insuffi cient, because in our sample it would have caused a 35 % error rate. Investigation of antibodies against seven phospholipids is thus considered to be reasonable and is benefi cial for infertility diagnosis (Tab. 2, Ref. 36). Text in PDF www.elis.sk.

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Etiology of sperm immunity in women

Cited by 34 publications

References 32 publications

Females discriminate against heterospecific sperm in a natural hybrid zone

Females discriminate against heterospecific sperm in a natural hybrid zone

Immunologic behavior of human cysteine-rich secretory protein 1 (hCRISP1) in primates: prospects for immunocontraception

Incidence of antibodies in women after failure of assisted reproduction

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