Etiology of recurrent pregnancy loss in women over the age of 35 years

Marquard, Kerri L.; Westphal, Lynn M.; Milki, Amin A.; Lathi, Ruth B.

doi:10.1016/j.fertnstert.2009.06.041

Cited by 107 publications

(77 citation statements)

References 58 publications

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“…In fact, a case control study comparing 420 karyotyped products of conception (POCs) specimens from 275 couples with RPL to two data sets from patients with sporadic losses detected more euploid specimens in women ,36 yr with RPL than in women ,36 yr with sporadic losses (Stephenson et al 2002). No differences in the number of euploid specimens were seen between the two groups in women 36 yr or older, likely reflecting the fact that fetal chromosomal abnormalities are found in the POCs of .70% of loses among women older than 35 who experience RPL (Marquard et al 2010). The detection of fewer chromosomal abnormalities in POCs from women with RPL strongly suggests that noncytogenetic etiologies also occur more frequently in women experiencing RPL than in those with sporadic losses and indicates a need for further evaluation in patients with two or more documented euploid losses.…”

Section: Fetal Aneuploidy In Sporadic and Recurrent Pregnancy Lossmentioning

confidence: 91%

Genetic Considerations in Recurrent Pregnancy Loss

Hyde

Schust

2015

Cold Spring Harbor Perspectives in Medicine

116

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Section: Fetal Aneuploidy In Sporadic and Recurrent Pregnancy Lossmentioning

confidence: 91%

Genetic Considerations in Recurrent Pregnancy Loss

Hyde

Schust

2015

Cold Spring Harbor Perspectives in Medicine

116

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“…Since the incidence of aneuploidy for products of conception is high, 50-80 % [4][5][6][7] it is expected that a reduction of aneuploid embryos might lead to a decreased incidence of pregnancy loss and an increased incidence of LDPS (Fig. 2).…”

Section: Delivery Per Embryo Transferredmentioning

confidence: 99%

“…For women over the age of 40 in the United States, roughly half of all clinical pregnancies established through IVF are lost, failing to result in live births (SART CORS Clinic Summary Report, 2012). It has been reported that approximately 50-80 % of all first trimester pregnancy losses result from chromosomal abnormalities in the developing fetus [4][5][6][7]. These abnormalities are a concern for couples seeking IVF treatment to conceive a healthy viable pregnancy.…”

Section: Introductionmentioning

confidence: 99%

In vitro fertilization with preimplantation genetic screening improves implantation and live birth in women age 40 through 43

Lee

McCulloh

Hodes-Wertz

et al. 2015

J Assist Reprod Genet

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Purpose In Vitro Fertilization is an effective treatment for infertility; however, it has relatively low success in women of advanced maternal age (>37) who have a high risk of producing aneuploid embryos, resulting in implantation failure, a higher rate of miscarriage or birth of a child with chromosome abnormalities. The purpose of this study was to compare the implantation, miscarriage and live birth rates with and without preimplantation genetic screening (PGS) of embryos from patients aged 40 through 43 years. Methods This is a retrospective cohort study, comparing embryos screened for ploidy using trophectoderm biopsy and array comparative genomic hybridization to embryos that were not screened. We compared pregnancy outcomes for traditional fresh IVF cycles with day 5 embryo transfers, Frozen Embryo Transfer (FET) cycles without PGS and PGS-FET (FET of only euploid embryos) cycles of patients with maternal ages ranging from 40 to 43 years, undergoing oocyte retrievals during the period between 1/1/2011 and 12/ 31/2012. Results The implantation rate of euploid embryos transferred in FET cycles (50.9 %) was significantly greater than for unscreened embryos transferred in either fresh (23. Conclusions The present data provides evidence of the benefits of PGS with regard to improved implantation and live birth rate per embryo transferred.

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“…There is a direct correlation between increasing age of the woman and degradation of the cellular controls that manage spindle cell formation and function [2]. This is especially true in women over 35 years old, with trisomy 16 being the most common [30].…”

Section: Genetic Causesmentioning

confidence: 99%

Immunogenetic contributions to recurrent pregnancy loss

Grimstad

Krieg

2016

J Assist Reprod Genet

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While sporadic pregnancy loss is common, occurring in 15 % of pregnancies, recurrent pregnancy loss (RPL) impacts approximately 5 % of couples. Though multiple causes are known (including structural, hormonal, infectious, autoimmune, and thrombophilic causes), after evaluation, roughly half of all cases remain unexplained. The idiopathic RPL cases pose a challenging therapeutic dilemma in addition to incurring much physical and emotional morbidity. Immunogenetic causes have been postulated to contribute to these cases of RPL. Natural Killer cell, T cell expression pattern changes in the endometrium have both been shown in patients with RPL. Human leukocyte antigen (HLA) and cytokine allelic variations have also been studied as etiologies for RPL. Some of the results have been promising, however the studies are small and have not yet put forth outcomes that would change our current diagnosis and management of RPL. Larger database studies are needed with stricter control criteria before reasonable conclusions can be drawn.

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Etiology of recurrent pregnancy loss in women over the age of 35 years

Cited by 107 publications

References 58 publications

Genetic Considerations in Recurrent Pregnancy Loss

Genetic Considerations in Recurrent Pregnancy Loss

In vitro fertilization with preimplantation genetic screening improves implantation and live birth in women age 40 through 43

Immunogenetic contributions to recurrent pregnancy loss

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