Etiology of Papilledema in Patients in the Eye Clinic Setting

Crum, Olivia M.; Kilgore, Khin P.; Sharma, Rishi; Lee, Michael S.; Spiegel, Matthew R.; McClelland, Collin M.; Bhatti, M. Tariq; Chen, John J.

doi:10.1001/jamanetworkopen.2020.6625

Cited by 36 publications

(41 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…We did not specifically record prescriptions of drugs such as tetracyclines and retinoids that can cause secondary intracranial hypertension although this probably accounts for a small number of cases. 23 IIH incidence and prevalence in Wales are increasing considerably, corresponding to population increases in BMI. IIH is associated with increasing deprivation in women even after adjusting for obesity, suggesting additional etiologic factors associated with deprivation apart from BMI.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Incidence, Prevalence, and Health Care Outcomes in Idiopathic Intracranial Hypertension

et al. 2021

View full text Add to dashboard Cite

Objective:To characterise trends in incidence, prevalence, and healthcare outcomes in the idiopathic intracranial hypertension (IIH) population in Wales using routinely collected healthcare data.Methods:We used and validated primary and secondary care IIH diagnosis codes within the Secure Anonymised Information Linkage databank, to ascertain IIH cases and controls, in a retrospective cohort study between 2003 and 2017. We recorded body mass index (BMI), deprivation quintile, CSF diversion surgery and unscheduled hospital admissions in case and control cohorts.Results:We analysed 35 million patient years of data. There were 1765 cases of IIH in 2017 (85% female). The prevalence and incidence of IIH in 2017 was 76/100,000 and 7.8/100,000/year, a significant increase from 2003 (corresponding figures=12/100,000 and 2.3/100,000/year) (p<0.001). IIH prevalence is associated with increasing BMI and increasing deprivation. The odds ratio for developing IIH in the least deprived quintile compared to the most deprived quintile, adjusted for gender and BMI, was 0.65 (95% CI 0.55 to 0.76). 9% of IIH cases had CSF shunts with less than 0.2% having bariatric surgery. Unscheduled hospital admissions were higher in the IIH cohort compared to controls (rate ratio=5.28, p<0.001) and in individuals with IIH and CSF shunts compared to those without shunts (rate ratio=2.02, p<0.01).Conclusions:IIH incidence and prevalence is increasing considerably, corresponding to population increases in BMI, and is associated with increased deprivation. This has important implications for healthcare professionals and policy makers given the comorbidities, complications and increased healthcare utilization associated with IIH.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Incidence, Prevalence, and Health Care Outcomes in Idiopathic Intracranial Hypertension

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In the current case, possible causes of papilledema including idiopathic intracranial hypertension, tumor, hemorrhage, venous sinus thrombosis, and granulomatous meningitis [ 3 ] were all denied by neuroimaging and lumbar puncture, and as a result, presence of GCA was diagnosed. In a retrospective review of consecutive 221 patients with bilateral ODS with preserved visual function, diagnosis other than papilledema was found only in 4 (1.8%) patients [ 1 ].…”

Section: Discussion/conclusionmentioning

confidence: 98%

“…ODS with preserved visual function differs between bilateral and unilateral cases. Bilateral ODS with preserved visual function is most often a result of papilledema due to intracranial pressure (ICP) elevation [ 1 , 3 ]. Further differential diagnosis is required when papilledema is ruled out, although such condition is rare [ 1 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Bilateral Optic Disc Swelling with Preserved Visual Function Associated with Giant Cell Arteritis

Mochiji

Yamane

Ishida

et al. 2021

Case Rep Ophthalmol

View full text Add to dashboard Cite

A 68-year-old Japanese man was introduced to our hospital for optic disc swelling (ODS) in his both eyes (OU). Other than floaters in his right eye, he did not report any symptoms including blurred vision, visual field defect, and ocular pain. Light reflex was prompt and complete OU, and critical flicker frequency was within the normal range OU. By fluorescein angiography, hyperfluorescence was detected on optic discs OU; however, no fluorescein leakage or filling defect was observed. By Goldmann perimetry, enlargement of the Mariotte blind spot was revealed OU, while no central scotoma or remarkable visual field defects were detected. By neuroimaging and lumbar puncture, papilledema due to intracranial pressure elevation was denied. Based on the reassessment of fundus findings, narrowing and segmental whitening/sheathing of peripapillary vessels predominantly to arterioles were realized, and systemic arteritis was suspected. Based on the subject age, elevation of erythrocyte sedimentation rate, positron emission tomography findings in the aorta, and MRI findings in temporal arteries, underlying giant cell arteritis (GCA) was diagnosed. After the start of systemic and local steroid therapies, ODS improved OU. Although rare, bilateral ODS with no visual disturbance can occur in patients with GCA. This case emphasizes the importance of careful assessment of ocular findings to reach the correct diagnosis of even a rare cause of ODS.

show abstract

“…12 The role of OCT is also pivotal in detecting other eye-related conditions like hyper-reflectivity due to macular telangiectasia type-2, 13 optic neuropathies, 14 and glaucomatous retinal nerve fiber layer loss. 15 Papilledema is a serious medical condition that leads to visual disturbances and occurs due to the optic disc's swelling because of increased intraocular pressure; 16,17 OCT technique can be used to measure the amount of optic disc edema in this condition. 18…”

Section: Ophthalmologymentioning

confidence: 99%

Optical coherence tomography’s current clinical medical and dental applications: a review

Ali

Gilani

Shabbir³

et al. 2021

F1000Res

View full text Add to dashboard Cite

Optical coherence tomography (OCT) is a non-invasive investigative technique that is used to obtain high-resolution three-dimensional (3D) images of biological structures. This method is useful in diagnosing diseases of specific organs like the eye, where a direct biopsy cannot be conducted. Since its inception, significant advancements have been made in its technology. Apart from its initial application in ophthalmology for retinal imaging, substantial technological innovations in OCT brought by the research community have enabled its utilization beyond its original scope and allowed its application in many new clinical areas. This review presents a summary of the clinical applications of OCT in the field of medicine (ophthalmology, cardiology, otology, and dermatology) and dentistry (tissue imaging, detection of caries, analysis of dental polymer composite restorations, imaging of root canals, and diagnosis of oral cancer). In addition, potential advantages and disadvantages of OCT are also discussed.

show abstract

Etiology of Papilledema in Patients in the Eye Clinic Setting

Cited by 36 publications

References 22 publications

Incidence, Prevalence, and Health Care Outcomes in Idiopathic Intracranial Hypertension

Incidence, Prevalence, and Health Care Outcomes in Idiopathic Intracranial Hypertension

Bilateral Optic Disc Swelling with Preserved Visual Function Associated with Giant Cell Arteritis

Optical coherence tomography’s current clinical medical and dental applications: a review

Contact Info

Product

Resources

About