Etiology of nutritional rickets: Geographic variations

Mimouni, Francis

doi:10.1016/s0022-3476(96)80122-3

Cited by 13 publications

(2 citation statements)

References 21 publications

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“…Geographic variations in the aetiology and epidemiology of nutritional rickets can result from differences in ultraviolet light exposure, skin pigmentation, diet and religious or custom-based habits. 5 We conducted a systematic review of the characteristics of nutritional rickets from around the world.…”

Section: Introductionmentioning

confidence: 99%

Nutritional rickets around the world: causes and future directions

Thacher

Fischer

Strand³

et al. 2006

Annals of Tropical Paediatrics

248

148

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Section: Introductionmentioning

confidence: 99%

Nutritional rickets around the world: causes and future directions

Thacher

Fischer

Strand³

et al. 2006

Annals of Tropical Paediatrics

248

148

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“…[3][4][5] These reports, which deviate from the earlier concept, have stimulated much interest. [6][7][8][9] More recently there have been reports of rickets apparently caused by calcium deficiency in Bangladesh 10 and also Colombia, 11 whereas the rickets associated with dietary calcium deficiency in India appears to be linked to fluoride toxicity. 12 Some evidence of healing of rickets with calcium has been reported from South Africa [13][14][15] and in Nigerian infants, 4 but this has remained controversial.…”

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confidence: 99%

Radiological and biochemical resolution of nutritional rickets with calcium * COMMENTARY

Oginni

Sharp²,

Badru³

et al. 2003

Archives of Disease in Childhood

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Aims: To determine the response to oral calcium in Nigerian children with rickets. Methods: In a teaching hospital in Western Nigeria, 26 children (13 boys, 13 girls, aged 2-5 years) with confirmed rickets received calcium lactate (2.7 g/day). Results: Within one month of treatment leg pain was relieved and the children were more active. The mean x ray score improved from 3.3 at baseline to 1.7 at three months and 0.9 at six months (arbitrary scoring system, 0-6). Twelve cases were healed radiologically after six months, 11 others improved considerably, two showed no significant improvement, and a non-compliant patient was worse. There was progressive reversal of biochemical features. Median plasma alkaline phosphatase fell from 519 (range 178-1078) to 283 (209-443) IU/l (p = 0.04) in four months, while mean 1,25-dihydroxyvitamin D fell from 473 (251-1057) to 281 (155-481) pmol/l (p = 0.04), and mean plasma calcium increased from 2.26 (1.63-2.54) to 2.37 (2.06-2.54) mmol/l (p = 0.13). Parathyroid hormone fell from 5.3 (0.4-21.5) to 1.7 (0.45-7.4) pmol/l. Type I collagen carboxy terminal cross linked telopeptide was very high at baseline (20 (7.2-103) to 14 (11-24) µg/l) (p = 0.03) and fell promptly to normal. Conclusion: Calcium supplementation alone effected healing of rickets in most of these Nigerian children and may provide sufficient treatment in this environment.

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