Etiology of non-B non-C hepatocellular carcinoma in the eastern district of Tokyo

Abe, Hiroshi; Yoshizawa, Kai; Kitahara, Toshihiro; Aizawa, Ryoichi; Matsuoka, Makoto; Aizawa, Yoshifusa

doi:10.1007/s00535-008-2264-8

Cited by 53 publications

(50 citation statements)

References 35 publications

(34 reference statements)

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“…The analysis of the characteristics of NBNC HCC indicated that the mean age, rate of complications associated with diabetes and BMI were significantly higher in these cases compared with cases of virus-related HCC, in agreement with previous reports (5)(6)(7)(8)(9)(10)(11)(12). Patients with NBNC HCC exhibited a good liver function, although a number of patients presented with a large tumor size (6), possibly as they were not examined periodically due to the absence of hepatitis virus infection.…”

Section: Discussionsupporting

confidence: 91%

Clinicopathological characteristics of hepatitis B surface antigen-negative and hepatitis C antibody-negative hepatocellular carcinoma

et al. 2015

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Abstract. The present study investigated the clinicopathological characteristics of resected hepatitis B virus surface antigen (HBs-Ag)-negative, hepatitis C virus antibody (HCV-Ab)-negative hepatocellular carcinoma (NBNC HCC). The clinicopathological characteristics of 164 patients with NBNC HCC, 144 patients with HBs-Ag-positive HCC (HBV group) and 550 patients with HCV-Ab-positive HCC (HCV group) were compared. In the NBCN HCC group, 61 patients succumbed after 2 years. Subsequently, NBCN HCC patients were compared according to survival time (<2 years, 39 patients vs. ≥2 years, 64 patients) to identify prognostic factors. Finally, the clinicopathological characteristics of NBNC HCC were compared according to history of alcohol abuse/pathological results: Non-alcoholic steatohepatitis HCC (NASH group, 40 patients), alcohol abuse HCC (AL group, 80 patients) and other HCCs (non-NASH/non-AL group, 44 patients). Age, diabetes prevalence and body mass index were significantly higher for NBNC HCC compared with virus-related HCC. Among stage II cases, the prognosis was significantly better for the NBNC compared with that for the HCV group. A high α-fetoprotein level, poorly differentiated HCC and advanced liver fibrosis were independent risk factors for the prognosis of NBNC HCC. The proportion of female patients was significantly higher among NASH compared with AL HCC patients. The cumulative survival rates following surgery were similar in the NASH, AL and non-NASH/non-AL groups. NBNC HCC is considered to be a lifestyle disease, with better prognosis for stage II patients. The prognostic factors for NBNC HCC patients undergoing hepatectomy were similar to those with virus-related HCC and did not differ according to alcohol abuse history or pathological results.

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Section: Discussionsupporting

confidence: 91%

Clinicopathological characteristics of hepatitis B surface antigen-negative and hepatitis C antibody-negative hepatocellular carcinoma

et al. 2015

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“…Occult infection with HBV represented by the presence of antibody to hepatitis B core antigen (anti-HBc) has been considered as a risk factor of non-B, non-C HCC defined as negative for both HBsAg and anti-HCV antibody [27,28]. Indeed the prevalence of anti-HBc antibody was higher in this study compared to a previous report in blood donors [29].…”

Section: Discussioncontrasting

confidence: 50%

680 Clinical Characteristics, Treatment and Prognosis of Non-B Non-C Hepatocellular Carcinoma: A Large Retrospective Multicenter Cohort Study

Tateishi¹,

Okanoue²,

Okita³

et al. 2013

Journal of Hepatology

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“…40 On the Eastern side, a study from Japan found that 17 of 320 (5.3%) HCC cases were either associated with NASH or had a cryptogenic etiology. 41 Cryptogenic hepatocellular carcinoma accounted for 5.4% of all HCC in Korea, and this group had higher BMI, TG levels, DM, and HTN compared with HCC with well-defined etiologies. 42 In another study from Korea, 20 of 36 (56%) patients with CHCC had at least two risk factors for NAFLD.…”

Section: Non-alcoholic Fatty Liver Disease and Cryptogenic Hepatocellmentioning

confidence: 90%

“…Also, the prevalence of obesity and diabetes was significantly higher in this cohort. 41 Formation of HCC in noncirrhotic livers in NASH is a cause of concern, and appropriate screening protocols for HCC in NASH need to be formulated like those for hepatitis B infection.…”

Section: Overweight/obesitymentioning

confidence: 99%

Non-alcoholic Fatty Liver Disease: East Versus West

Agrawal

Duseja

2012

Journal of Clinical and Experimental Hepatology

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Non-alcoholic fatty liver disease (NAFLD) is an important cause of liver disease worldwide with prevalence ranging from 10% to 30% in various countries. It has become an important cause of unexplained rise in transaminases, cryptogenic cirrhosis, and cryptogenic hepatocellular carcinoma. Pathogenesis is related to obesity, insulin resistance, oxidative stress, lipotoxicity, and resultant inflammation in the liver progressing to fibrosis. Pharmacological treatment in patients with NAFLD is still evolving and the treatment of these patients rests upon lifestyle modification with diet and exercise being the cornerstones of therapy. While there are many similarities between patients with NAFLD from Asia and the West, there are certain features which make the patients with NAFLD from Asia stand apart. This review highlights the data on NAFLD from Asia comparing it with the data from the West. ( J CLIN EXP HEPATOL 2012;2:122-134)

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Etiology of non-B non-C hepatocellular carcinoma in the eastern district of Tokyo

Abstract: Alcohol consumption and NAFLD may be important etiological factors in non-B non-C HCC. Periodic medical assessments for all patients with non-B non-C cirrhosis are crucial for early diagnosis and curative therapy.

Cited by 53 publications

References 35 publications

Clinicopathological characteristics of hepatitis B surface antigen-negative and hepatitis C antibody-negative hepatocellular carcinoma

Clinicopathological characteristics of hepatitis B surface antigen-negative and hepatitis C antibody-negative hepatocellular carcinoma

680 Clinical Characteristics, Treatment and Prognosis of Non-B Non-C Hepatocellular Carcinoma: A Large Retrospective Multicenter Cohort Study

Non-alcoholic Fatty Liver Disease: East Versus West

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