Etiology of clinically isolated, severe, chronic, pure mitral regurgitation: Analysis of 97 patients over 30 years of age having mitral valve replacement

Waller, Bruce F.; Morrow, Andrew G.; Maron, Barry J.; Negro, Albert A. Del; Kent, Kenneth M.; McGrath, Francis J; Wallace, Robert B.; McIntosh, Charles L.; Roberts, William C.

doi:10.1016/0002-8703(82)90204-6

Cited by 196 publications

(49 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Valve disease was considered degenerative 18,19 if it was due to primary floppy valves, flail leaflets, and/or calcified mitral annulus. Clinical characteristics, comorbidity (Charlson index 20 ), and symptoms were based on independent physician assessment of the patients.…”

Section: Methodsmentioning

confidence: 99%

Surgical Correction of Mitral Regurgitation in the Elderly

Détaint¹,

Sundt²,

Nkomo³

et al. 2006

Circulation

145

View full text Add to dashboard Cite

Background-In the elderly, mitral regurgitation (MR) is frequent, but surgery risks are considered high. Benefits and indications of MR surgery are uncertain in the elderly. Methods and Results-Baseline characteristics, outcome, and trends for surgical results improvement were analyzed in elderly patients (Ն75 years of age; nϭ284) operated on for MR in 1980 to 1995 compared with younger patients (65 to 74 years of age, nϭ504; and Ͻ65 years of age, nϭ556). Preoperatively, class III to IV symptoms, atrial fibrillation, coronary disease, creatinine, and comorbidity index were more severe in elderly patients (all PϽ0.002). In the long term after surgery, observed survival stratified by age (Ն75, 65 to 74, Ͻ65 years) was lower in elderly than in younger patients (at 5 years, 57Ϯ3%, 73Ϯ2%, and 85Ϯ2%, respectively; PϽ0.001), but ratios of observed to expected survival were similar (83%, 85%, and 88%, respectively

show abstract

Section: Methodsmentioning

confidence: 99%

Surgical Correction of Mitral Regurgitation in the Elderly

Détaint¹,

Sundt²,

Nkomo³

et al. 2006

Circulation

145

View full text Add to dashboard Cite

show abstract

“…Whether this is indicative of a true decrease in the frequency of rheumatic heart disease alone or very likely, in addition to more stringent diagnostic criteria is unclear. As was discussed by Waller et al (1982), their criteria for isolated severe pure MR were stringent in that they excluded all patients with associated mitral stenosis and aortic valve disease. This degree of selection may well explain the different frequencies of rheumatic involvement in those two studies.…”

Section: Etiology Of Mitral Regurgitationmentioning

confidence: 99%

“…Waller et al (1982), reported that in a series of 97 patients with isolated severe chronic, pure MR, rheumatic heart disease was the etiology in only 3% of the cases. They found that mitral valve prolapse (62 %) and coronary artery disease (30%) were the most common etiologies.…”

Section: Introductionmentioning

confidence: 98%

Clinical and echocardiographic features of isolated severe pure mitral regurgitation

Pizzarello

Turnier

Dworkin

et al. 1984

Clinical Cardiology

View full text Add to dashboard Cite

Summary:Recent studies have shown that rheumatic heart disease is no longer the main cause of isolated severe pure mitral regurgitation. In this study, we evaluated various clinical and echocardiographic features found in the syndrome of mitral regurgitation. Our data is consistent with recent reports that mitral valve prolapse and coronary artery disease are now the predominant causes of mitral regurgitation and that rheumatic heart disease is a much less common etiology. In addition, our data suggest that clinical evaluation alone is usually very accurate in identifying the correct etiology. Various clinical and echocardiographic features found in the subsets of acute and chronic mitral regurgitation are described. Specifically, patients with acute mitral regurgitation were more likely to have echocardiographic evidence of segmental left ventricular dysfunction and flail mitral valve leaflet. In chronic mitral regurgitation, atrial fibrillation and left atrial dilatation were more commonly present. Echocardiography was found to be more useful in the detection of the

show abstract

“…[8][9][10][11] Increased awareness of the prevalence of mitral valve prolapse and improved diagnostic methods have led to its frequent identification in young adults. Because the occurrence of severe mitral regurgitation increases with age, 3,6,8,11,12 2 These data provide support for the figure of 4% prevalence in men and for the risks we have estimated for men.…”

mentioning

confidence: 99%

Lifetime risk for patients with mitral valve prolapse of developing severe valve regurgitation requiring surgery.

1988

View full text Add to dashboard Cite

Severe mitral regurgitation requiring surgery is the most common life-threatening complication of mitral valve prolapse (MVP) , and 1:28 (22-41), respectively. In women, the risk was less than half that in men (p<0.001). We conclude that the risk of developing severe mitral regurgitation is age and sex related, is minimal before the age of 50, and rises sharply after the age of 50, particularly in men, and that the current minimum number of patients requiring myxomatous mitral valve surgery in Australia is between 150 and 200 per year, a caseload that will increase with the advancing age of the population. The findings are consistent with the predictions of a response-to-injury hypothesis that explains the pathogenesis of progressive changes in the prolapsing mitral valve. (Circulation 1988;78:10-14) P rimary mitral valve prolapse, as opposed to that secondary to a systemic disorder of connective tissue or to a reduction in left ventricular cavity size, occurs with a prevalence of 2.5-5% in the adult population, according to recent surveys using careful clinical and echocardiographic diagnostic criteria. [1][2][3][4] It is relatively uncommon before the growth spurt of adolescence,5,6 but thereafter, the prevalence in men remains relatively constant. Most studies have found a greater prevalence in women than in men, and among women, there are data suggesting a greater prevalence in adolescence and young adulthood. 1,4 (However,

show abstract

Etiology of clinically isolated, severe, chronic, pure mitral regurgitation: Analysis of 97 patients over 30 years of age having mitral valve replacement

Cited by 196 publications

References 3 publications

Surgical Correction of Mitral Regurgitation in the Elderly

Surgical Correction of Mitral Regurgitation in the Elderly

Clinical and echocardiographic features of isolated severe pure mitral regurgitation

Lifetime risk for patients with mitral valve prolapse of developing severe valve regurgitation requiring surgery.

Contact Info

Product

Resources

About