Etiology of Bronchiectasis in a Cohort of 2047 Patients. An Analysis of the Spanish Historical Bronchiectasis Registry

Olveira, Casilda; Padilla, Alicia; Martínez-García, Miguel-Ángel; Rosa, David de la; Girón, Rosa; Vendrell, Montserrat; Máiz, Luís; Borderías, Luis; Polverino, Eva; Martínez‐Moragón, Eva; Rajas, Olga; Maldonado, Francisco Casas; Cordovilla, Rosa; Gracia, Javier de

doi:10.1016/j.arbr.2017.05.005

Cited by 43 publications

(55 citation statements)

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“…We report a 36% rate of postinfectious bronchiectasis, which is compatible with previous studies (20-70%) [6,[9][10][11]. A history of tuberculosis is positively associated with the presence of chronic respiratory diseases, particularly bronchiectasis [32].…”

Section: Discussionsupporting

confidence: 92%

“…We reported a 32% rate of idiopathic bronchiectasis, which is comparable to previous studies (6 to 77%) [6,[9][10][11]. Idiopathic bronchiectasis was reported to be highly variable because of differences in enrolled study populations, criteria of etiologies and whether diagnoses are based on diagnostic exams or ICD codes.…”

Section: Discussionsupporting

confidence: 86%

“…Bronchiectasis can occur from early childhood to late adulthood, but the average age in US, European, and Australasian cohorts is between 60 and 70 years, and the incidence of bronchiectasis is positively associated with age [1][2][3]. Geographic variation exists in the etiology, incidence, prevalence and clinical features [4][5][6][7][8][9]. The most common cause of bronchiectasis is post-infection and other causes include chronic obstructive pulmonary disease (COPD), asthma, connective tissue disease and immunodeficiency [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Geographic variation exists in the etiology, incidence, prevalence and clinical features [4][5][6][7][8][9]. The most common cause of bronchiectasis is post-infection and other causes include chronic obstructive pulmonary disease (COPD), asthma, connective tissue disease and immunodeficiency [4][5][6]. Previous studies have reported a lower incidence of COPD and asthma as etiologies of bronchiectasis in Asia than in Western countries [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Etiology and characteristics of patients with bronchiectasis in Taiwan: a cohort study from 2002 to 2016

Huang

Chung

et al. 2020

BMC Pulm Med

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Background: Bronchiectasis is a chronic infectious respiratory disease with diverse causes and ethnic or geographic differences. However, few large-scale studies of its etiology have been conducted in Asia. This study aimed to determine the etiology and clinical features of bronchiectasis in Taiwan.Methods: This longitudinal cohort study investigated the etiology and clinical features of newly diagnosed noncystic fibrosis bronchiectasis patients from January 2002 to December 2016. The clinical, functional and microbiological data of patients were retrieved from the Chang Gung Research Database, which includes seven medical facilities throughout Taiwan. The index date was the date of the first bronchiectasis diagnosis. Known diseases that were diagnosed before the index date were regarded as etiologies of bronchiectasis. Results: The cohort comprised 15,729 adult patients with bronchiectasis. Idiopathic (32%) was the most common cause, followed by post-pneumonia (24%). Other causes included post-tuberculosis (12%), chronic obstructive pulmonary disease (14%), asthma (10%), gastroesophageal reflux disease (2%) and rheumatic diseases (2%). At diagnosis, 8487 patients had sputum culture. Pseudomonas aeruginosa (5.3%) was the most common bacteria, followed by non-tuberculosis mycobacteria (3.6%), Haemophilus influenzae (3.4%) and Klebsiella pneumoniae (3.1%), but 6155 (72.1%) had negative sputum cultures. Patients with post-tuberculosis had a higher sputum isolation rate of non-tuberculosis mycobacteria than P. aeruginosa. Patients with post-tuberculosis and post-pneumonia bronchiectasis had a higher frequency of chronic lung infection than other groups (p < 0.05). Clinical characteristics, such as gender, lung function, comorbidities and microbiology, were significantly different between idiopathic and known etiologies.Conclusions: Idiopathic, post-infection and tuberculosis constitute major bronchiectasis etiologies in Taiwan. Clinical characteristics and sputum microbiology were distinct among separate etiology phenotypes.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Etiology and characteristics of patients with bronchiectasis in Taiwan: a cohort study from 2002 to 2016

Huang

Chung

et al. 2020

BMC Pulm Med

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“…Some reports have suggested an association, even a causal link, between emphysema and bronchiectasis 55 . The prevalence of α1-ATD in bronchiectasis is very low [56][57][58] . Conversely, the frequency of bronchiectasis in α1-ATD is difficult to ascertain and varies from one study to another (27-60%).…”

Section: Bronchiectasis and Alpha-1 Antitrypsin Deficiency And Emphysemamentioning

confidence: 99%

Bronchiectasis in Chronic Obstructive Airway Disease: More than a Comorbidity?

Martínez‐García¹,

Ferrer²,

Olmeda³

2017

BRN

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Beyond the bronchial dilatations associated with age, several studies have documented a higher prevalence of bronchiectasis in patients with severe asthma or chronic obstructive pulmonary disease (COPD). Perhaps COPD or asthmatic patients with bronchiectasis represent a clinical phenotype characterised by greater clinical and functional severity, a higher number of exacerbations and, in the case of COPD, greater colonisation by potentially pathogenic microorganisms and probably a poor prognosis. Although international guidelines recommend that the two diseases are treated separately when they coexist, patients with COPD or asthma associated with bronchiectasis may benefit from specific treatments, such as long-term antibiotics, physiotherapy or macrolides. It is biologically plausible that severe asthma, and especially severe COPD, are related to de novo bronchiectasis, but no study has yet demonstrated any cause-effect relationship. Early diagnosis and treatment of bronchiectasis in COPD and asthma could be crucial to improve their prognosis. This relationship poses an interesting scientific challenge for the future. (BRN Rev. 2017;3:178-91)

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