Etiology for Liver Diseases in Pediatric Population

Karakkattu, Jismy; Pr, Roshni

doi:10.22159/ajpcr.2017.v10i1.14121

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…In the first case, the symptoms appear during the first months of life and improve up to 12-24 mo in 80% of the cases. Since the 1980s, there have been major advancements in the medical management of gastroesophageal reflux disease (GERD) [3]. The most successful therapies have increased acid secretion and volume with H2receptor antagonists and especially proton-pump inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Evaluation and Optimization of Sustained-Release Drug Delivery System of Cisapride Tablet

Ram¹,

Pankhaniya²

2021

Int J Pharm Pharm Sci

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Objective: Cisapride is a novel prokinetic agent is best candidate for GERD. Cisapride 20 mg can be given thrice in a day given along with Proton pump inhibitor. By developing the sustain release formulation of Cisapride, the frequency of both drug can be reduce to once only to obtain good therapeutic response. Methods: Cisapride SR Tablets were prepared by direct compression technique with HPMC K4M and HPMC K100M polymers. Followed by various evaluation tests including in vitro disintegration and dissolution, the formulation was optimized by 32 full factorial designs with drug release kinetic analysis, compatibility studies (FTIR) and stability studies. Results: Results of Preformulation studies of the Cisapride indicate that it has poor flow property and compressibility property. To improve the flow and compressibility property, it was beneficial to use the directly compressible grade components in the formulation of tablet. Results of DSC study shown that there is no change in drug’s melting peak after the preparation of tablet. Hydrophilic matrix of HPMC K4M and HPMC K100M in combination sustained the Cisapride release effectively for more than 12h. The result indicates that the combination of HPMCK4M and HPMCK100M can be successfully, On the basis of the preliminary trials in the present study a32 full factorial design was employed to study the effect of independent variables, i.e. concentration of HPMCK4M(X1) and concentration of HPMCK100M(X2)on dependent variables like% drug release Q2, Q6 and Q10. Drug release is also dependent on the size of matrix tablets so, size and surface area was kept constant. Factorial batches F018, F019, F020, and F021 give the f2 value 75-100. Factorial batch F019 gives the highest f2 value 86.04 and also all the hour’s drug release was within the specified limits. Conclusion: The prepared formulation of Cisapride sustains release matrix tablet was stable and effective in treatment.

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Section: Introductionmentioning

confidence: 99%

Formulation, Evaluation and Optimization of Sustained-Release Drug Delivery System of Cisapride Tablet

Ram¹,

Pankhaniya²

2021

Int J Pharm Pharm Sci

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“…Cirrhosis is a common liver disease that is a process of normal hepatic cells being distorted by fibrosis and nodular regeneration, which finally leads to the disorganisation and malfunction of the liver …”

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confidence: 99%

Diagnostic value of serum cytokeratin‐18 in children with chronic liver disease

Shalby

Ibrahim

Behairy

et al. 2019

J Paediatrics Child Health

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EgyptAim: This study aimed to assess the diagnostic value of serum cytokeratin-18 in children with chronic liver diseases (CLD) and correlate its serum level with liver histology and other liver biomarkers. Methods: This study included two groups, the first group included children with CLD and the second group included healthy matched age and gender subjects as a control group, complete history and clinical examination, and serum CK-18 was measured using the sandwich enzyme-linked immunosorbent assay technique. Results: Serum concentrations of CK-18 were significantly elevated in CLD patients with mean AE standard deviation (1070.63 AE 699.2 ng/mL) compared to healthy controls mean AE standard deviation (203.95 AE 83.57 ng/mL). CK-18 levels were associated with a change in hepatocyte and portal tract (P = 0.005) as it was elevated with cirrhosis and fibrosis stage (P = 0.02) as it was elevated with moderate and severe fibrosis than mild fibrosis, also it showed a gradual increase in accordance with child Pugh score. There was a positive correlation between CK-18 levels and Total IgG, paediatric end-stage liver disease score and model for end-stage liver disease scores, the best cutoff point of CK-18 was 624 ng/mL, with sensitivity 93.06%, specificity 62.5% and diagnostic accuracy 90.0% for detection of fibrosis. Conclusion: CK-18 could be used as a non-invasive diagnostic marker in children with CLD.

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Etiology for Liver Diseases in Pediatric Population

Cited by 2 publications

References 10 publications

Formulation, Evaluation and Optimization of Sustained-Release Drug Delivery System of Cisapride Tablet

Formulation, Evaluation and Optimization of Sustained-Release Drug Delivery System of Cisapride Tablet

Diagnostic value of serum cytokeratin‐18 in children with chronic liver disease

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