2015
DOI: 10.1016/j.ejpn.2015.05.007
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Etiology, clinical course and response to the treatment of status epilepticus in children: A 16-year single-center experience based on 602 episodes of status epilepticus

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Cited by 40 publications
(48 citation statements)
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References 23 publications
(21 reference statements)
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“…Bolus dosing and initial infusion rates for midazolam were similar to those reported in previous studies, [1123] with a median dose of 0.11 mg/kg (average in the literature 0.15 – 0.50 mg/kg) and 1.7 mcg/kg/min (average in the literature 1 – 2 mcg/kg/min) respectively. However, previous studies identified an apparent discrepancy: treatment dosing from studies using EEG monitoring to guide therapy [13,19] used considerably higher doses of midazolam when compared with studies using a clinical endpoint to guide treatment (10.7 mcg/kg/min versus 2.8 mcg/kg/min).…”
Section: Discussionsupporting
confidence: 82%
See 1 more Smart Citation
“…Bolus dosing and initial infusion rates for midazolam were similar to those reported in previous studies, [1123] with a median dose of 0.11 mg/kg (average in the literature 0.15 – 0.50 mg/kg) and 1.7 mcg/kg/min (average in the literature 1 – 2 mcg/kg/min) respectively. However, previous studies identified an apparent discrepancy: treatment dosing from studies using EEG monitoring to guide therapy [13,19] used considerably higher doses of midazolam when compared with studies using a clinical endpoint to guide treatment (10.7 mcg/kg/min versus 2.8 mcg/kg/min).…”
Section: Discussionsupporting
confidence: 82%
“…[1223] The current prospective pSERG cohort from 2011 to 2013 adds contemporary data to this literature. The proportion of RSE patients presenting to emergency services needing midazolam infusion is substantial, occurring in 29% to 47% of patients (95% CI), a finding that may have implications for hospital emergency services.…”
Section: Discussionmentioning
confidence: 99%
“…The number of patients per study ranged from as small as one to as large as 358 children 127 and 339 adults. 128 Efficacy (as determined by cessation of clinical or electrographic RSE when MDZ was the last ASM added) was 56% in neonates. 126 Efficacy was 46.7% to 100% (median = 89%, regardless of sample size) across the studies in children.…”
Section: Resultsmentioning
confidence: 99%
“…Furthermore, other retrospective studies not specifically designed to look at CLB in SE have reported conflicting results. Although 3 studies have reported treatment failure with CLB, 2 studies have reported treatment success . Due to the retrospective nature of those studies it is unknown whether remission was due to the effect of CLB, or rather its effect in combination with other AEDs.…”
Section: Resultsmentioning
confidence: 99%
“…Although 3 studies have reported treatment failure with CLB, [13][14][15] 2 studies have reported treatment success. 16,17 Due to the retrospective nature of those studies it is unknown whether remission was due to the effect of CLB, or rather its effect in combination with other AEDs.…”
Section: Efficacy Of Clobazam In Status Epilepticusmentioning
confidence: 99%