Etiology and Risk Factors of Severe and Protracted Diarrhea

Guarino, Alfredo; Spagnuolo, Maria Immacolata; Russo, Stefania; Albano, Fabio; Guandalini, Stefano; Capano, G.; Cucchiara, Salvatore; Vairano, P.; Liguori, Roberto; Casola, Antonella; Rubino, A

doi:10.1097/00005176-199502000-00006

Cited by 70 publications

(55 citation statements)

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“…Otherwise, IEL in a normal small bowel biopsy is a somewhat nonspecific histological finding. ncreased E counts have also been described in patients without CD, such as in cases of allergic enteritis, autoimmune disorders, tropical sprue, HP-associated gastritis, viral infections, and enteropathy-associated T-cell lymphoma [21][22][23][24][25]. In this study, the HP-positive rates of all groups were 68.8 , 64.7 , and 64.2 in the NCD, , and E groups, respectively.…”

Section: Discussionsupporting

confidence: 53%

What Is the Clinical Importance of White Spots in the Duodenum?

2017

Ann Clin Anal Med

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Section: Discussionsupporting

confidence: 53%

What Is the Clinical Importance of White Spots in the Duodenum?

2017

Ann Clin Anal Med

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“…The term "intractable diarrhea of infancy" embraces a heterogeneous syndrome with a diverse etiology. By "protracted diarrhea (PD) in early childhood," we allude to children whose diarrhea start within the first 2 yr of life, becomes life threatening, and leads to dependence on parenteral nutrition (PN) for at least two weeks (2). Several chronic enteropathies that may be responsible for intractable diarrhea have been described.…”

Section: Introductionmentioning

confidence: 99%

Protracted Diarrhea: Results of the Five-year Survey in a Tertiary Hospital in Korea

2001

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The syndrome of protracted diarrhea (PD) includes several diseases with diverse etiologies. This study was conducted to characterize the spectrum of causes, clinical manifestations, and the outcomes of PD. A retrospective analysis of the clinical and pathological findings was performed on 25 patients with diarrhea starting within the first 2 yr of life and a requirement of parenteral nutrition (PN). According to the intestinal histopathology, patients were classified into four groups: immune enteropathy (12 cases), lymphangiectasia (6 cases), epithelial dysplasia (5 cases), and unclassified (2 cases). All patients with epithelial dysplasia had earlier onset of diarrhea and longer duration of PN than those in the other groups. Three patients (12%) had an evidence of a familial condition. Five patients (three with microvillous inclusion disease and two with immune enteropathy) died. Sixteen patients recovered, and three (two with primary lymphangiectasia and one with microvillous inclusion disease) still had diarrhea. One patient underwent intestinal transplantation for tufting enteropathy. In conclusion, infants with PD should be referred to specialized centers where advanced diagnostic and therapeutic facilities are available, because histological analysis is critical for the diagnosis of PD, and PN or intestinal transplantation is the only therapeutic option in a subset of cases.

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“…7 The infectious agents were Salmonella, coagulase-positive Staphylococcus, Rotavirus, Adenovirus and Cryptosporidium. CMV infection was not detected and in most patients not looked for.…”

Section: What Other Diseases Cause Idi?mentioning

confidence: 99%