Etiology and genetic evolution of canine coronavirus circulating in five provinces of China, during 2018–2019

He, Hai Jian; Zhang, Wenyan; Liang, Jiawei; Lu, Meng; Wang, Ruyi; Li, Gairu; He, Jia; Chen, Jun; Xing, Gang; Chen, Ye

doi:10.1016/j.micpath.2020.104209

Cited by 28 publications

(19 citation statements)

References 58 publications

(67 reference statements)

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“…Also, several other factors indicate that SARS-CoV-2 virus that spread in Europe and USA vs Bangladesh may be different in some features, which need to be clarified in future. 17 – 19 Also, the age and other general profiles of the patients may have influenced the outcome. Data supporting this concept is on rise as several thousand COVID-19 patients have died in Europe and USA, the fatality is still low in Asian and African countries.…”

Section: Discussionmentioning

confidence: 99%

Treatment of COVID-19 Patients at a Medical College Hospital in Bangladesh

Bhuyan

Mahtab

Ashab

et al. 2020

Euroasian Journal of Hepato-Gastroenterology

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Background and aim Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has induced a sense of panic around the world as the disease is highly contagious and has been spreading in full swing during last 5 months causing millions of COVID-19 patients and hundreds of thousands of deaths. Bangladesh, a country of 170 million people, is not an exception regarding COVID-19; it has reported several thousand COVID-19 patients with several hundred of deaths. This observational study has been planned to assess the scope and limitation of management strategy against COVID-19 patients in a medical college hospital of Bangladesh with available drugs in a real-life situation. Materials and methods All patients in this cohort ( N : 33) were positive for SARS-CoV-2 by polymerase chain reaction (PCR) and they attended the hospital with variable presenting symptoms those ranged from cough and fever to respiratory distress and pneumonia. As per the protocol, the patients were regularly evaluated for several parameters of COVID-19-related pathology. Before discharge, they were checked for SARS-CoV-2 for 2 consecutive times. The management strategy included standard of care (SoC) and administration of hydroxychloroquine and azythromycin, available in Bangladesh. Results Out of total 33 patients, 1 patient died at day 4 day after admission. Two patients developed severe complications and were referred to tertiary hospital in Dhaka (2 and 3 days after admission), the capital of Bangladesh, where they recovered and were discharged from hospital after being SARS-CoV-2 negative. The rest 30 patients were discharged from the medical college hospital after being negative for SARS-CoV-2 in two subsequent assessments and improvement of their COVID-related symptoms. The average hospital stay of these patients was 14.5 days with a range of 10–24 days. Conclusion It seems that most of the COVID-19 patients may be adequately managed by standard of care management with drug support. However, early diagnosis and hospitalization with adequate care may be important variables for better survival. These factors may be properly ensured if the patient burden remains at a palatable level in forthcoming days in Bangladesh. How to cite this article Bhuyan MAR, Al Mahtab M, Ashab E, et al. Treatment of COVID-19 Patients at a Medical College Hospital in Bangladesh. Euroasian J Hepato-Gastroenterol 2020;10(1):27–30.

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Section: Discussionmentioning

confidence: 99%

Treatment of COVID-19 Patients at a Medical College Hospital in Bangladesh

Bhuyan

Mahtab

Ashab

et al. 2020

Euroasian Journal of Hepato-Gastroenterology

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“…However, it may be considered that the SARS-CoV-2 virus that spread in Europe and USA vs Bangladesh may be different. 18 , 19 Data supporting this concept has started to emerge. Also, epidemiological data strongly favors such a hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Real-life Management Strategy of COVID-19 Patients in Bangladesh with No Death: An Observational and Cohort Study

Huq¹,

Rahman²,

Islam³

et al. 2020

Euroasian Journal of Hepato-Gastroenterology

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Background Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared as pandemic by World Health Organization (WHO) with increasing morbidity (more than 4.6 million patients) and mortality (300,000 deaths). The world-wide target of management COVID-19 is to reduce complications with available management options; this become highly variable from country to country and even within different regions of the same country. Aim and objective This observational prospective study represents a single center study in which all patients in this cohort received almost similar medicines and care. Materials and methods All patients in this cohort ( N : 32) were positive for SARS-CoV-2 by polymerase chain reaction (PCR) with variable presenting symptoms. The management strategy included Standard of Care (SoC) and administration of hydroxychloroquine and doxycycline. Out of 32 patients, 9 patients also received favipiravir. All patients were followed until they were discharged after negativity of SARS-CoV-2 confirmed by PCR on two consecutive occasions taken within 2 days. Results No death has been recorded in this cohort of 32 patients within the study period. The average hospital staying duration was 13.9 days with a range of 8–21 days. All patients were discharged with improvement of subjective symptoms and SARS-CoV-2 negativity. The vital signs (pulse, blood pressure) as well as and levels of electrolyte and blood counts were within normal and acceptable ranges at the time of discharge. Conclusion The study presented here provide and evidence of a real-life situation of management of limited numbers of COVID-19 patients at a tertiary center of Bangladesh. This study inspires optimism that proper diagnosis, establishment of effective inclusion and exclusion criteria, ensuring application of proper SoC with drugs available in Bangladesh may be a practical option for management of COVID-19 in the country. How to cite this article Huq AKMF, Rahman MF, Islam MA, et al. Real-life Management Strategy of COVID-19 Patients in Bangladesh with No Death: An Observational and Cohort Study. Euroasian J Hepato-Gastroenterol 2020;10(1):31–35.

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“…The principal confirmed transmission routes of the latter viruses are animal-to-person and person-to-person which can occur through droplets formed by a cough or sneeze as well as close contact with spatters of infected persons. However, the fecal-oral route of transmission was observed in other members of this family such as canine coronavirus ( He et al, 2020 ), equine coronavirus ( Nemoto, Schofield, & Cullinane, 2019 ), and feline coronavirus (C. Li et al, 2019 ). Although the COVID-19 is generally known by respiratory symptoms, many studies have shown that some patients, contracting this infection with gastrointestinal symptoms, have viral particles in their feces ( Hindson, 2020 ).…”

Section: Introductionmentioning

confidence: 99%