Etiology and antimicrobial resistance patterns in pediatric urinary tract infection

Wang, Jun; He, Lijiao; Sha, Jintong; Zhu, Haobo; Huang, Lingli; Zhu, Xiaofang; Dong, Jun; Li, Guogen; Ge, Zheng; Lu, Rongzhu; Ma, Geng; Shi, Yaqi; Guo, Yunfei

doi:10.1111/ped.13526

Cited by 21 publications

(31 citation statements)

References 21 publications

(27 reference statements)

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“…Arguments that infants with UTI can be easily treated with oral antibiotics apply to older males as oral administration in infants is difficult and absorption is low, requiring hospitalization to enable intravenous antibiotic administration . Emergence of resistance to most or all antibiotics, including methicillin, will make treatment of UTI more challenging . Maternal antibiotic use during pregnancy also increase the risk of resistant pathogens during neonatal UTI .…”

Section: Resultsmentioning

confidence: 99%

“…14,38 Emergence of resistance to most or all antibiotics, including methicillin, will make treatment of UTI more challenging. [39][40][41][42][43][44] Maternal antibiotic use during pregnancy also increase the risk of resistant pathogens during neonatal UTI. 45 Subpreputial swabs of boys aged 7 days to 11 years identified 50 bacterial isolates, most being multidrug-resistant strains, 46 and of boys aged 2 months to 9 years identified 72 microorganisms, including 54…”

Section: Urinary Tract Infectionmentioning

confidence: 99%

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Critical evaluation of arguments opposing male circumcision: A systematic review

Morris

Moreton²,

Krieger

2019

J Evidence Based Medicine

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Objective To systematically evaluate evidence against male circumcision (MC). Methods We searched PubMed, Google Scholar, EMBASE and Cochrane databases. Results Database searches retrieved 297 publications for inclusion. Bibliographies of these yielded 101 more. After evaluation we found: Claims that MC carries high risk were contradicted by low frequency of adverse events that were virtually all minor and easily treated with complete resolution. Claims that MC causes psychological harm were contradicted by studies finding no such harm. Claims that MC impairs sexual function and pleasure were contradicted by high‐quality studies finding no adverse effect. Claims disputing the medical benefits of MC were contradicted by a large body of high‐quality evidence indicating protection against a wide range of infections, dermatological conditions, and genital cancers in males and the female sexual partners of men. Risk‐benefit analyses reported that benefits exceed risks by 100‐200 to 1. To maximize benefits and minimize risks, the evidence supported early infant MC rather than arguments that the procedure should be delayed until males are old enough to decide for themselves. Claims that MC of minors is unethical were contradicted by balanced evaluations of ethical issues supporting the rights of children to be provided with low‐risk, high‐benefit interventions such as MC for better health. Expert evaluations of case‐law supported the legality of MC of minors. Other data demonstrated that early infant MC is cost‐saving to health systems. Conclusions Arguments opposing MC are supported mostly by low‐quality evidence and opinion, and are contradicted by strong scientific evidence.

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Section: Resultsmentioning

confidence: 99%

Section: Urinary Tract Infectionmentioning

confidence: 99%

Critical evaluation of arguments opposing male circumcision: A systematic review

Morris

Moreton²,

Krieger

2019

J Evidence Based Medicine

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“…All subjects were admitted for the study from 1 January 2013 to 31 July 2016 in Nanjing Children's Hospital – the affiliated hospital of Nanjing Medical University. The inclusion criteria were similar to those used in our previous study . The clinical demographics and characteristics (gender, age, height, and weight), prognosis of UTI, complications, duration of hospitalization, urine culture results, antibiotics, catheterization as well as the biochemistry, were all collected by two independent authors (J.W.…”

Section: Methodsmentioning

confidence: 99%

“…The standard method for processing and testing urine culture samples was as previously described . The expected primary outcome of this study was the prognosis of UTI in pediatric patients.…”

Section: Methodsmentioning

confidence: 99%

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Risk factors affecting the prognosis of urinary tract infection in Chinese pediatric patients: Single‐center experience

Wang

Zhu

Huang

et al. 2020

Pediatrics International

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Background Urinary tract infection (UTI) is common in children. The purpose of this retrospective study was to determine the various risk factors that usually affect the prognosis of UTI in children diagnosed with the disease. Methods In the present retrospective study, we enrolled all pediatric patients diagnosed with UTI and hospitalized between 1 January 2013 and 31 July 2016 at Nanjing Children's Hospital. We then collected all the relevant patient clinical demographics and characteristics. Results The study involved 2,092 pediatric patients diagnosed with UTI. On logistic regression analysis, factors that could affect the prognosis of pediatric UTI were complications, hospitalization, intensive care unit (ICU) admission, type of UTI, urine culture results, blood lymphocytes, urine nitrites (NIT) and antibiotics (unstandardized coefficients, 0.06, <0.001, −0.28, 0.32, <0.001, 0.01, −0.11, 0.01, respectively, all P < 0.001). Conclusion Complications, hospitalization, type of UTI, urine culture results, blood lymphocytes, and antibiotics had a significant, positive association with UTI prognosis. Meanwhile, ICU admission and urine NIT had a negative association with prognosis.

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Infections du tractus urinaire en milieu pédiatrique : écologie bactérienne et sensibilité aux antibiotiques au Centre hospitalier universitaire pédiatrique Charles-de-Gaulle de Ouagadougou (Burkina Faso)

Savadogo

Tondé

et al. 2021

Néphrologie & Thérapeutique

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Etiology and antimicrobial resistance patterns in pediatric urinary tract infection

Abstract: There is high antibiotic resistance in hospitalized children with UTI. Susceptibility testing should be carried out on all clinical isolates, and the empirical antibiotic treatment should be altered accordingly.

Cited by 21 publications

References 21 publications

Critical evaluation of arguments opposing male circumcision: A systematic review

Critical evaluation of arguments opposing male circumcision: A systematic review

Risk factors affecting the prognosis of urinary tract infection in Chinese pediatric patients: Single‐center experience

Infections du tractus urinaire en milieu pédiatrique : écologie bactérienne et sensibilité aux antibiotiques au Centre hospitalier universitaire pédiatrique Charles-de-Gaulle de Ouagadougou (Burkina Faso)

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