Etiologies, outcomes, and risk factors for epilepsy in infants: A case–control study

Masri, Amira; Badran, Eman; Hamamy, Hanan; Assaf, Abeer; Al-Qudah, Abdelkarim A.

doi:10.1016/j.clineuro.2007.12.013

Cited by 20 publications

(13 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…• There is no high-level evidence to support any particular current agents for use in infants with seizures. Overall, infantile (epileptic) spasms constitute the largest single epilepsy subgroup, representing 13-45.5% of infantile population-based incidence studies 44,47,[52][53][54][55][56] For other seizure types there are limited data beyond case series (class 3 and 4 studies) The outcomes reported in typically class 4 studies suggest that seizures in infancy are predictive of comorbidities as well as complex and poor outcomes 52,53,55 Clinical semiology/ types of epileptic events…”

Section: Methodsmentioning

confidence: 99%

Summary of recommendations for the management of infantile seizures: TaskForceReport for theILAE Commission ofPediatrics

et al. 2015

View full text Add to dashboard Cite

Summary Evidence‐based guidelines, or recommendations, for the management of infants with seizures are lacking. A Task Force of the Commission of Pediatrics developed a consensus document addressing diagnostic markers, management interventions, and outcome measures for infants with seizures. Levels of evidence to support recommendations and statements were assessed using the American Academy of Neurology Guidelines and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. The report contains recommendations for different levels of care, noting which would be regarded as standard care, compared to optimal care, or “state of the art” interventions. The incidence of epilepsy in the infantile period is the highest of all age groups (strong evidence), with epileptic spasms the largest single subgroup and, in the first 2 years of life, febrile seizures are the most commonly occurring seizures. Acute intervention at the time of a febrile seizure does not alter the risk for subsequent epilepsy (class 1 evidence). The use of antipyretic agents does not alter the recurrence rate (class 1 evidence), and there is no evidence to support initiation of regular antiepileptic drugs for simple febrile seizures (class 1 evidence). Infants with abnormal movements whose routine electroencephalography (EEG) study is not diagnostic, would benefit from video‐EEG analysis, or home video to capture events (expert opinion, level U recommendation). Neuroimaging is recommended at all levels of care for infants presenting with epilepsy, with magnetic resonance imaging (MRI) recommended as the standard investigation at tertiary level (level A recommendation). Genetic screening should not be undertaken at primary or secondary level care (expert opinion). Standard care should permit genetic counseling by trained personal at all levels of care (expert opinion). Genetic evaluation for Dravet syndrome, and other infantile‐onset epileptic encephalopathies, should be available in tertiary care (weak evidence, level C recommendation). Patients should be referred from primary or secondary to tertiary level care after failure of one antiepileptic drug (standard care) and optimal care equates to referral of all infants after presentation with a seizure (expert opinion, level U evidence). Infants with recurrent seizures warrant urgent assessment for initiation of antiepileptic drugs (expert opinion, level U recommendation). Infantile encephalopathies should have rapid introduction and increment of antiepileptic drug dosage (expert opinion, level U recommendation). There is no high level evidence to support any particular current agents for use in infants with seizures. For focal seizures, levetiracetam is effective (strong evidence); for generalized seizures, weak evidence supports levetiracetam, valproate, lamotrigine, topiramate, and clobazam; for Dravet syndrome, strong evidence supports that stiripentol is effective (in combination with valproate and clobazam), whereas weak evidence supports that topiramate, zonisamide,...

show abstract

Section: Methodsmentioning

confidence: 99%

Summary of recommendations for the management of infantile seizures: TaskForceReport for theILAE Commission ofPediatrics

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Offspring of consanguineous unions are at increased risk for genetic syndromes, including seizure disorders, due to the presence of deleterious autosomal recessive genes inherited from a common ancestor or the inheritance of polygenic disorders. Several previous studies have shown that consanguinity may be an important risk factor for developing seizures, including prenatal, perinatal, and infantile epilepsy [1,4,9]. In the present case, two affected siblings were born to consanguineous parents, suggesting that autosomal recessive inheritance is likely.…”

Section: Discussionmentioning

confidence: 58%

Recurrent fetal seizures diagnosed in the offspring of consanguineous parents

Benjamin

Hines

Khozaim

et al. 2014

Case Reports in Perinatal Medicine

View full text Add to dashboard Cite

Fetal seizures are relatively rare and most often associated with anomalies or adverse neonatal outcome. We describe a patient who presented in both her G1 and G2 pregnancies with fetal seizures. The second pregnancy was a twin gestation in which only one twin was affected. The fetal seizures were noted by the patient as "extreme rhythmic movement" and were observed on ultrasound. Both neonates were diagnosed with a seizure disorder within 1 day of life. Currently, the seizures are controlled by medication; however, both children have some developmental delay. Additionally, the patient and her partner are consanguineous, suggesting a likely genetic etiology. In utero diagnosis of fetal seizures warrants a multidisciplinary approach to attempt to further define prognosis and provide appropriate treatment and counseling.

show abstract

“…A recent study conducted in Iran showed in an epileptic population that 61% of the parents of the patients were first cousins and 20.4% were second cousins, and the authors concluded familial marriages increased the risk of epilepsy by at least by 2.2-fold [21]. A similar study from Jordan showed consanguinity was a major risk factor for epilepsy [22]. Wakamoto et al [23] studied the family history and consanguinity in 311 patients with childhood-onset epilepsy, and found that 19.3% had a family history and 6.1% consanguinity.…”

Section: Discussionmentioning

confidence: 93%

Frequency of Epilepsies in Family Members of Patients with Different Epileptic Syndromes

Sözmen

Baybaş²,

Dırıcan³

et al. 2010

Eur Neurol

View full text Add to dashboard Cite

Aim: To determine the frequency of epilepsies in the family members of epileptic patients. Methods: The records of 4,851 patients with epilepsy were reviewed. The frequency and patterns of different epilepsies and epileptic syndromes in the patients, number of affected relatives and consanguinity were studied. Results: A total of 1,753 patients were excluded due to various reasons. Of the remaining patients, 296 (9.5% of 3,098) had first- or second-degree relatives affected with seizures. The incidence of family history in the localization-related cryptogenic epilepsies group was significantly higher than all other groups (246 patients). Juvenile myoclonic epilepsy was the most frequent epileptic syndrome (34 patients). Consanguinity was detected in 56 patients, and 33 (58.9%) of these subjects were in the localization-related cryptogenic epilepsies group. Of all subjects, 59 (19.9%) had more than 1 epileptic family member. The ratio of affected first- to second-degree relatives was 202/94. Conclusions: A considerable number of the relatives of epileptic patients have seizures. The risk of relatives being affected depends on their relationship with the proband. Genetic factors may play an almost equal role in the predisposition of relatives to epilepsy in families of probands with cryptogenic and idiopathic epileptic syndromes.

show abstract

Etiologies, outcomes, and risk factors for epilepsy in infants: A case–control study

Cited by 20 publications

References 32 publications

Summary of recommendations for the management of infantile seizures: TaskForceReport for theILAE Commission ofPediatrics

Summary of recommendations for the management of infantile seizures: TaskForceReport for theILAE Commission ofPediatrics

Recurrent fetal seizures diagnosed in the offspring of consanguineous parents

Frequency of Epilepsies in Family Members of Patients with Different Epileptic Syndromes

Contact Info

Product

Resources

About