Etiologies of tropical acute febrile illness in West Pahang, Malaysia: A prospective observational study

Thabit, Alif Adlan Mohd; Mutalip, Mohd Hatta Abdul; Kamil, Wan Mohd Rasis Wan Ahmad; Din, Mohd Ramadhan Mohd; Arumugam, Muthu; Azman, Siti Sanaa Wan; Jaafar, Rosmina; Singh, Sathvinder Singh Gian; Abdullah, Rafidah; Muhammad, Eida Nurhadzira; Muhamad, Nor Asiah

doi:10.4103/1995-7645.278096

Cited by 4 publications

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“…The northeast Thailand collection was collected from patients participated in our longitudinal cohort study 7 . The patients were from nine provinces including Udon Thani (n = 230), Mukdahan (n = 198), Roi Et (n = 195), Surin (n = 170), Nakhon Phanom (n = 135), Buriram (n = 123), Sisaket (n = 107), Khon Kaen (n = 96) and Maha Sarakham (n = 11), who were admitted to nine hospitals included in our cohort.…”

Section: Methodsmentioning

confidence: 99%

Section: Data Collection and Bacterial Isolatesmentioning

confidence: 99%

“…Historically, limited access to microbiology laboratories for culture-confirmed diagnosis led to underreporting, particularly in lower-and middle-income countries 2 . However, improved infrastructure and awareness have led to increases in reported cases across South Asia, Southeast Asia, East Asia [3][4][5][6][7][8] and Australia 9,10 In Southeast Asia, the disease incidence is often linked to agriculture practice, particularly during the rainy seasons when rice paddy fields are flooded for planting. The flooded terrain enables the bacterium in the soil to surface, potentially exposing farmers to B. pseudomallei and subsequently leading to melioidosis 11 .…”

Section: Introductionmentioning

confidence: 99%

“…The disease has been historically underreported due to limited availability of microbiology laboratory infrastructure required for culture-confirmed melioidosis diagnosis, particularly in lower-and middle-income countries. Although recent reports of increasing melioidosis cases in South Asia, Southeast Asia, East Asia [2][3][4][5][6][7] and Australia 8,9 may partly be attributed to improved microbiology infrastructure and growing disease awareness, the cases have often been associated with severe weather events [10][11][12] . While climate likely influences human encounters with B. pseudomallei, further investigation is needed to fully understand the mechanisms linking environmental factors to melioidosis epidemiology.…”

Section: Introductionmentioning

confidence: 99%

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Genetic diversity, determinants, and dissemination ofBurkholderia pseudomalleilineages implicated in melioidosis in northeast Thailand

Seng

Tandhavanant

Saiprom

et al. 2023

Preprint

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Melioidosis is an often-fatal neglected tropical disease caused by an environmental bacterium Burkholderia pseudomallei. However, our understanding of disease-causing bacterial lineages, dissemination, and their adaptive mechanisms remains limited. To address this, we conducted comprehensive genomic analysis of 1,265 B. pseudomallei isolates collected from nine hospitals in northeast Thailand between 2015 and 2018, presenting the most densely sampled collection to date. Our study identified four dominant lineages with unique gene sets enhancing bacterial fitness, indicating lineage-specific co-colonisation strategies. Crucially, recombination was found to drive lineage-specific gene flow. Transcriptome analysis of a representative isolate from one lineage revealed upregulation of lineage-specific genes under nutrient-depletion. Our study also demonstrated the impact of river systems, monsoons, and typhoons in shaping the geographical dispersal of B. pseudomallei. Collectively, our findings underscore the importance of bacterial persistence in the environment as a prelude to exposure and infection, thereby providing insights for melioidosis prevention and control strategies.

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Section: Methodsmentioning

confidence: 99%

Section: Data Collection and Bacterial Isolatesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genetic diversity, determinants, and dissemination ofBurkholderia pseudomalleilineages implicated in melioidosis in northeast Thailand

Seng

Tandhavanant

Saiprom

et al. 2023

Preprint

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Genetic diversity, determinants, and dissemination of Burkholderia pseudomallei lineages implicated in melioidosis in Northeast Thailand

Seng,

Chomkatekaew,

Tandhavanant

et al. 2024

Nat Commun

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Melioidosis is an often-fatal neglected tropical disease caused by an environmental bacterium Burkholderia pseudomallei. However, our understanding of the disease-causing bacterial lineages, their dissemination, and adaptive mechanisms remains limited. To address this, we conduct a comprehensive genomic analysis of 1,391 B. pseudomallei isolates collected from nine hospitals in northeast Thailand between 2015 and 2018, and contemporaneous isolates from neighbouring countries, representing the most densely sampled collection to date. Our study identifies three dominant lineages, each with unique gene sets potentially enhancing bacterial fitness in the environment. We find that recombination drives lineage-specific gene flow. Transcriptome analyses of representative clinical isolates from each dominant lineage reveal increased expression of lineage-specific genes under environmental conditions in two out of three lineages. This underscores the potential importance of environmental persistence for these dominant lineages. The study also highlights the influence of environmental factors such as terrain slope, altitude, and river direction on the geographical dispersal of B. pseudomallei. Collectively, our findings suggest that environmental persistence may play a role in facilitating the spread of B. pseudomallei, and as a prerequisite for exposure and infection, thereby providing useful insights for informing melioidosis prevention and control strategies.

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Burden and Risk Factors of Melioidosis in Southeast Asia: A Scoping Review

Selvam

Ganapathy

Najib

et al. 2022

IJERPH

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This scoping review aims to provide a comprehensive overview of human melioidosis in Southeast Asia as well as to highlight knowledge gaps in the prevalence and risk factors of this life-threatening disease using available evidence-based data for better diagnosis and treatment. Preferred Reporting Items for Systematic Review and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) was used as the guideline for this review. The literature search was conducted on 23 March 2022 through two electronic databases (PubMed and Scopus) using lists of keywords referring to the Medical Subject Headings (MeSH) thesaurus. A total of 38 articles related to human melioidosis were included from 645 screened articles. These studies were carried out between 1986 and 2019 in six Southeast Asian countries: Thailand, Cambodia, Malaysia, Myanmar, Singapore, and Vietnam. Melioidosis has been reported with a high disease prevalence among high-risk populations. Studies in Thailand (48.0%) and Cambodia (74.4%) revealed disease prevalence in patients with septic arthritis and children with suppurative parotitis, respectively. Other studies in Thailand (63.5%) and Malaysia (54.4% and 65.7%) showed a high seroprevalence of melioidosis among Tsunami survivors and military personnel, respectively. Additionally, this review documented soil and water exposure, diabetes mellitus, chronic renal failure, thalassemia, and children under the age of 15 as the main risk factors for melioidosis. Human melioidosis is currently under-reported in Southeast Asia and its true prevalence is unknown.

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Etiologies of tropical acute febrile illness in West Pahang, Malaysia: A prospective observational study

Cited by 4 publications

References 0 publications

Genetic diversity, determinants, and dissemination ofBurkholderia pseudomalleilineages implicated in melioidosis in northeast Thailand

Genetic diversity, determinants, and dissemination ofBurkholderia pseudomalleilineages implicated in melioidosis in northeast Thailand

Genetic diversity, determinants, and dissemination of Burkholderia pseudomallei lineages implicated in melioidosis in Northeast Thailand

Burden and Risk Factors of Melioidosis in Southeast Asia: A Scoping Review

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