Etiologies of community-onset urinary tract infections requiring hospitalization and antimicrobial susceptibilities of causative microorganisms

Chiu, Chih-Chien; Lin, Tzu-Chao; Wu, Ruixue; Yang, Ya-Sung; Hsiao, Po-Jen; Lee, Yi; Lin, Jung‐Chung; Chang, Feng–Yee

doi:10.1016/j.jmii.2016.08.008

Cited by 25 publications

(22 citation statements)

References 11 publications

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“…In this study, nearly half of the isolates were resistant to the majority of the tested antimicrobials, with 34.6% of the strains demonstrating MDR, which is in agreement with previous studies conducted in different regions of Turkey 12,24 . In accordance with the results of the study, 67.3%, 50.9%, 45.1%, 45.1%, 38.7%, 36.6%, 35.9%, 35.9%, and 32.7% were resistant to ampicillin, amoxicillin-clavulanic acid, cefazolin, trimethoprimsulfamethoxazole, cefuroxime, ceftriaxone, ciprofloxacin, cefepime, and norfloxacin, respectively, which are the first-line therapeutic agents used for UTI treatment 23,25 . These resistance rates may be explained by the frequent prescription of these antimicrobials in empirical treatment of UTIs.…”

Section: Determination Of Antimicrobial Resistance and Virulencesupporting

confidence: 89%

“…Increased antimicrobial resistance rates, particularly for beta-lactams, sulfamethoxazole-trimethoprim, third generation cephalosporins, and fluoroquinolones, has led to challenges in clinical practice 23 . In this study, nearly half of the isolates were resistant to the majority of the tested antimicrobials, with 34.6% of the strains demonstrating MDR, which is in agreement with previous studies conducted in different regions of Turkey 12,24 .…”

Section: Determination Of Antimicrobial Resistance and Virulencementioning

confidence: 99%

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Phylogenetic Group/Subgroups Distributions, Virulence Factors, and Antimicrobial Susceptibility of Escherichia coli Strains from Urinary Tract Infections in Hatay

Yılmaz

Aslantaş

2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Nosocomial and community acquired urinary tract infections (UTIs) are one of the most encountered infections in the world. Methods: This study aimed to determine the antibiotic susceptibility, phylogeny, and virulence genes of 153 Escherichia coli strains isolated from UTIs. Antimicrobial susceptibility of the isolates to different classes of antimicrobials was determined by the VITEK-2 automated system. Presence of virulence genes and phylogenetic groups were investigated by PCR. Results: Regarding susceptibility to antimicrobials, ampicillin resistance was most abundant (67.3%), followed by amoxicillin-clavulanic acid (50.9%); least abundant was resistance to amikacin (1.3%) and nitrofurantoin (1.3%). Multi drug resistance (MDR) was observed in 34.6% of the isolates, and all isolates were found to be susceptible to imipenem, meropenem and fosfomycine. The majority of the isolates belonged to the phylogenetic group B2 3 (35.9%), followed by A1 (20.9%), D1 (18.9%), D2 (12.4%), A0 (%5.9), B1 (3.9%) and B2 (1.9%). Among E. coli strains examined, 49% had iucD, 32.7% papE-F, 26.1% papC, 15% cnf2, 11.1% sfa, 7.8% cnf1, 1.3% afaE, 1.3% afaD, 1.3% hlyA, 0.7% f17a-A, 0.7% clpG and 0.7% eaeA genes. Conclusions: Our research demonstrated that virulence factors were distributed among different phylogroup/subgroups, which play a role in UTIs pathogenesis in humans. For this reason, complex and detailed studies are required to determine the relationship between virulence factors and specific E. coli strains that cause UTIs in humans. FIGURE 1: PCR amplification of E. coli specific 16S rRNA gene (401 bp).

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Section: Determination Of Antimicrobial Resistance and Virulencesupporting

confidence: 89%

Section: Determination Of Antimicrobial Resistance and Virulencementioning

confidence: 99%

Phylogenetic Group/Subgroups Distributions, Virulence Factors, and Antimicrobial Susceptibility of Escherichia coli Strains from Urinary Tract Infections in Hatay

Yılmaz

Aslantaş

2020

Rev. Soc. Bras. Med. Trop.

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“…14 UTI may be complicated by AKI. 3,15 Older age, diabetes, upper UTI, poor base-line renal functions are reported risk factors for AKI in UTI. 15 In our study, we evaluated ESBL-positivity of organisms causing UTI as risk factor for AKI.…”

Section: Discussionmentioning

confidence: 99%

Urinary Tract Infection due to Extended-Spectrum Beta-Lactamase Producing Organisms is a Risk Factor for Acute Kidney Injury among Patients with Type 2 Diabetes Mellitus

et al. 2017

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Background: Urinary tract infection (UTI) is common and diabetic patients are at increased risk for UTI. UTI may be complicated by acute kidney injury (AKI).the world. 3-6 Extended-spectrum beta-lactamase (ESBL) producing strains are an ever increasing problem 7-9 and diabetic patients with long duration and poor glycaemic control are at increased risk for UTI due to ESBL-positive organisms. 5,10 UTI may be complicated by acute kidney injury (AKI) and sepsis. 3 This study was designed to evaluate whether UTI due to ESBL-positive organisms should be considered as a risk factor for AKI in type 2 diabetic subjects. Methods:This case-control study was done in the Department of Internal Medicine and Department of Nephrology of Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital, Dhaka, Bangladesh from April to June 2016. Hospitalized patients with a clinical diagnosis of UTI were initially enrolled for the study purpose. A clean catch technique was applied for urine (preferably early morning midstream specimen) collection.

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“…However, our cases were resistant to cotrimoxazole/trimethoprim in contrast to his series where cotrimoxazole was found to be second drug of choice. 11 Chih-C C et al also reported E.coli responsible for 54.5% cases of UTI and about 13.1% cases. He reported Amikacin and Gentamycin as the drug of choice.…”

Section: Discussionmentioning

confidence: 92%

Urinary Tract Infection, Incidence, Uropathogens and Antibiotic Sensitivity in Females

Mahaseth¹,

Verma²,

Malla³

2017

J. Nepalgunj Med. College

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Introduction: Urinary tract infection in female population is one of the most common clinical infectious pathologies found worldwide due to anatomical location of urethral opening in relation to males. Continuous assessment of uropathogens and their sensitiveness to chemotherapeutic agent help us to manage these. The aim of this study to determine the presence of uropathpgens and their sensitkng from UTI. Method: It is a hospital based cross sectional study conducted at NGMC Teaching Hospital Kohalpur from July 2016 to June 2017. The urine samples were collected using the mid-stream clean catch method from 948 clinically suspected UTI female patients and the irantibiotic sensitiveness was determined using the standard procedures. Result: Overall culture positive was found in 262 patients (27.6%) among 948 urine samples. Among them e. coli contributed to cases 179(68.3%) followed by klebsiella 38(14.5%), enterobacter 21(8%), fungal 10(3.9%).Maximum no. of uropathogens were sensitive to chloramphenicol 224(93.4%) followed by nitrofurantin 232(88.7%), amikacin 246(94%), tobramycin 241(92.8%) and gentamycin 229(85.5%). Most of the organism were found to be resistant with ampicillin 255(97.5%) followed by cefpodoxime 242(92.4%), vancomycin 235(90%) and amoxicillin 234(89.6). Conclusion: and recommendation – Chloramphenicol, Nitrofurantin, Amikacin, Gentamicin and Tobramycinare the drugs of choice for the empirical therapytill the culture and sensitivity report is available. Continuous assessment is required for the early diagnosis and management of UTI.The culture and the sensitiveness of uropathogen are to be done and the treatment should be modified accordingly.

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Etiologies of community-onset urinary tract infections requiring hospitalization and antimicrobial susceptibilities of causative microorganisms

Cited by 25 publications

References 11 publications

Phylogenetic Group/Subgroups Distributions, Virulence Factors, and Antimicrobial Susceptibility of Escherichia coli Strains from Urinary Tract Infections in Hatay

Phylogenetic Group/Subgroups Distributions, Virulence Factors, and Antimicrobial Susceptibility of Escherichia coli Strains from Urinary Tract Infections in Hatay

Urinary Tract Infection due to Extended-Spectrum Beta-Lactamase Producing Organisms is a Risk Factor for Acute Kidney Injury among Patients with Type 2 Diabetes Mellitus

Urinary Tract Infection, Incidence, Uropathogens and Antibiotic Sensitivity in Females

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