Etiologies, mechanisms, and risk factors of ischemic stroke in a young Asian adult cohort

Tan, S; Ho, Jamie Sin-Ying; Sia, Ching‐Hui; Leow, Aloysius Sheng‐Ting; Seet, Raymond C.S.; Teoh, Hock Luen; Yuen, Linus Zh; Tham, Carol Huilian; Chua, Christopher Yuan Kit; Yap, Eng Soo; Chan, Bernard P.L.; Lim, Mervyn Jun Rui; Sharma, Vijay K.; Yeo, Leonard L.L.; Tu, Tian Ming; Tan, Benjamin Yong-Qiang

doi:10.1016/j.jstrokecerebrovasdis.2023.107134

Cited by 3 publications

(1 citation statement)

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“…Though, one of the important causes of young strokes, our study underreported arterial dissections and APLA syndromes. As compared to our study, a higher rate of APLA positivity was observed in one South East Asian young stroke cohort [ 25 ]. As a routine part of care in our institute, we consider APLA positivity only after double confirmation with two tests done 12 weeks apart due to the high rate of false positivity.…”

Section: Discussioncontrasting

confidence: 71%

Risk Factors and Stroke Subtyping in Young Adults: A Study From a Tertiary Care Hospital in South India

Shivde,

Badachi,

Deepalam

et al. 2024

Cureus

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Objectives: This study aimed to determine the risk factors and stroke subtypes for young ischemic stroke patients and their outcomes at the time of discharge. Methods: This is a retrospective cross-sectional study of ischemic stroke patients (n = 264) between the age groups of 18 and 45. The study population was divided into two broad age groups: 18 to 35 years and 36 to 45 years; and compared based on demographics, risk factors, the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification, and outcomes. The outcomes were compared based on the National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (MRS) systems at the time of admission and discharge. Results: The mean age of patients was 37.84±6.19 years. The male-to-female ratio was 2.5:1. The most common vascular risk factors identified were diabetes (29.16%), hypertension (49.62%), dyslipidaemia (DLP, 44.4%), and smoking (10.9%). The most common TOAST subtype was large vessel disease (38.63%), followed by the undetermined category (35.6%). The elderly group showed a high proportion of strokes secondary to small vessel disease (14.13%; p = 0.03), while cardioembolic strokes were common in the female subgroup (p = 0.05). The majority of strokes were in the anterior circulation (66.6%) as compared to the posterior (25.75%), and nearly 50% of the patients had intracranial disease. Overall, there was a favourable MRS outcome at discharge. Conclusion: Conventional vascular risk factors are equally prevalent, even among young stroke patients. The benchmark for young stroke age is showing a downward shift as more stroke patients above the age of 35 are showing similar risk factor trends as those of their older counterparts. The majority of stroke burden still falls under the undermined category, which requires aggressive risk factor identification and management.

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Section: Discussioncontrasting

confidence: 71%