Etiologies and Outcomes of Acute Liver Failure in Germany

Hadem, Johannes; Tacke, Frank; Bruns, Tony; Langgartner, Julia; Strnad, Pavel; Denk, Gerald; Fikatas, Panagiotis; Manns, Michael P.; Hofmann, Wolf Peter; Gerken, Guido; Grünhage, F; Umgelter, Andreas; Canbay, Ali

doi:10.1016/j.cgh.2012.02.016

Cited by 120 publications

(85 citation statements)

References 22 publications

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“…22 In the UK, 23 paracetamol overdose was the commonest etiology (57%) ALF, as was in the USA, 24 and Europe. 25,26 One exception is Spain, where the incidence of acetaminophen overdose is relatively low. 27 Other drugs responsible include NSAIDs, antiepileptics, antimicrobial agents such as antituberculosis therapy (ATT; isoniazid, usually in combination with other medications such as rifampicin and pyrazinamide), antibiotics and antifungals.…”

Section: Acute and Subacute Liver Failurementioning

confidence: 99%

Approach to Clinical Syndrome of Jaundice and Encephalopathy in Tropics

Anand

Garg

2015

Journal of Clinical and Experimental Hepatology

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Section: Acute and Subacute Liver Failurementioning

confidence: 99%

Approach to Clinical Syndrome of Jaundice and Encephalopathy in Tropics

Anand

Garg

2015

Journal of Clinical and Experimental Hepatology

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“…Studies from the West and Japan have not highlighted this issue, as the number of pregnant patients developing ALF is relatively small. Table 1 [20][21][22][23][24][25][26][27] provides reported global data on frequency of female preponderance among ALF patients as well as frequency of pregnancy among females with ALF.…”

Section: Hepatitis E Virus Burdenmentioning

confidence: 99%

Hepatitis E and Acute Liver Failure in Pregnancy

Shalimar

Acharya

2013

Journal of Clinical and Experimental Hepatology

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“…In Germany, druginduced ALF is the most common cause of the disease with an incidence of 32% followed by viral hepatitis with 21%, while the cause remains unknown in 24% of cases. Autoimmunity as a cause of ALV is rare (1). However, in all cases, it has been observed with widespread hepatocellular necrosis beginning in the centrizonal distribution and progressing towards the portal tracts.…”

Section: Introductionmentioning

confidence: 99%

De-Novo Autoimmune Hepatitis with Consecutive Acute Liver Failure Induced by Hepatitis E Infection: A Case Report

et al. 2017

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A 49-year-old male patient was referred to our institution for acute liver failure (ALV). Apart from cholestasis, coagulopathy, and hepatic encephalopathy (HE) I°, laboratory studies revealed a significant increase in liver enzymes with an alanine aminotransferase (ALT) level of 4'108 U/L and an aspartate aminotransferase (AST) level of 3'878 U/l (normal < 50 U/L), a constellation essentially compatible with autoimmune hepatitis (AIH). Work-up of serological markers for hepatitis E (HEV-IgM and PCR) was at the same time positive. Furthermore, the patient was strongly positive for antinuclear autoantibodies (ANA) with a titer of 1:1'280 (normal upper limit 1:80), and also presented hypergammaglobulinemia (immunoglobulin IgG-level of 21.3 g/L; normal 7, 0 -16, 0 g/L). Liver histology demonstrated massive hepatitis and necrosis with the presence of plasma cells. Due to the diagnosis of de-novo autoimmune hepatitis, therapy with steroids was performed despite the evidence of acute HEV-infection. It was of great importance that the patient recovered completely while neither antiviral therapy with ribavirin nor liver transplantation (LT) was necessary in the further course.

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Etiologies and Outcomes of Acute Liver Failure in Germany

Cited by 120 publications

References 22 publications

Approach to Clinical Syndrome of Jaundice and Encephalopathy in Tropics

Approach to Clinical Syndrome of Jaundice and Encephalopathy in Tropics

Hepatitis E and Acute Liver Failure in Pregnancy

De-Novo Autoimmune Hepatitis with Consecutive Acute Liver Failure Induced by Hepatitis E Infection: A Case Report

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