Etiologies and Features of Acute Viral Hepatitis in Spain

Llaneras, Jordi; Riveiro‐Barciela, Mar; Rando-Segura, Ariadna; Marcos‐Fosch, Cristina; Roade, Luisa; Velázquez, Fernando; Rodríguez‐Frías, Francisco; Esteban, Rafael; Buti, María

doi:10.1016/j.cgh.2020.07.006

Cited by 16 publications

(17 citation statements)

References 26 publications

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“…This was coincident with a predominance of acute hepatitis episodes during the first period in contrast with more frequent hepatic decompensation events in patients with cirrhosis during the second period. In support of our findings, a recent study that examined the current cause of acute viral hepatitis in Spain highlighted the scarcity of HDV infections [25].…”

Section: Discussionsupporting

confidence: 89%

Hepatitis delta in patients hospitalized in Spain (1997–2018)

Ramos-Rincón

Pinargote

Ramos-Belinchón

et al. 2021

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Background: Hepatitis delta is the most aggressive form of chronic viral hepatitis. We examined the clinical burden, epidemiological features and time trends for hepatitis delta patients hospitalized in Spain during the last two decades.Methods: Retrospective, observational study using the Spanish National Registry of Hospital Discharges. Information was retrieved since 1997 to 2018.Results: From a total of 79 647 783 nationwide hospital admissions recorded during the study period, 5179 included hepatitis delta as diagnosis. The overall hospitalization rate because of hepatitis delta was 6.5/10 5 , without significant yearly changes. In-hospital death occurred in 335 (6.6%) patients. Acute hepatitis and cirrhosis were recorded in 46.5 and 33.5% of hepatitis delta hospitalizations, respectively. Acute hepatitis delta predominated until 2007 (55.9%) whereas cirrhosis increased since then (39.4%). Hepatic decompensation events and liver cancer accounted on average for 16 and 8% of hospitalizations, increasing significantly over time. Coinfection with HIV and hepatitis C virus (HCV) were recognized in 24 and 31.2% of hepatitis delta patients, respectively. All hepatitis C, HIV and injection drug use declined significantly since 2008. Conclusion:The rate of hepatitis delta in patients hospitalized in Spain is low and has remained stable over two decades. However, hepatitis delta-related decompensation events and liver cancer are on the rise. The association of hepatitis delta with injection drug use, HIV and HCV has declined among recently hospitalized hepatitis delta patients.

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Section: Discussionsupporting

confidence: 89%

Hepatitis delta in patients hospitalized in Spain (1997–2018)

Ramos-Rincón

Pinargote

Ramos-Belinchón

et al. 2021

Aids

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“…En los últimos años, el número de notificaciones ha disminuido notablemente y se estima que este descenso se debe a que la vacunación ha reducido drásticamente la incidencia, como se ha observado en algunas comunidades autónomas 2 . A pesar de ello, y como muestra un estudio recientemente publicado en nuestro país, la causa más frecuente de hepatitis viral aguda sigue siendo todavía la hepatitis B, que supone el 20% de todos los casos 3 .…”

Section: Introductionunclassified

“…This is believed to be due to vaccination and the corresponding drop in incidence, which has been observed in some regions in Spain 2 . However, a recently published Spanish showed that the most common cause of acute viral hepatitis continues to be hepatitis B (20% of all cases 3 ).…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and treatment of hepatitis B. What contributions can prisons make?

Vergara¹

2021

Rev Esp Sanid Penit

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Hepatitis B is a parenterally and sexually transmitted infection. Vaccination for the disease is highly effective, and its inclusion in Spain as part of a systematic and universal schedule for newborns has led to a significant decrease of incidence in the national population. However, the number of inmates born in other countries - some from endemic areas of HBV infection -, the mechanisms of transmission and lack of vaccination in third world countries mean that its prevalence in the prison population is higher than in the general population. These institutions therefore play an essential role in detecting and managing hepatitis B. In this paper, the situation of hepatitis B in prisons is reviewed and recommendations are proposed to optimize its control.

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“…En un estudio reciente realizado en adultos que acudían al servicio de urgencias de un hospital universitario de Cataluña por un cuadro compatible con hepatitis aguda, la infección por VHB supuso la principal causa etológica 5 , correspondiendo un tercio de los casos a personas inmigrantes de países sin programas de vacunación y destacando la transmisión sexual como el principal factor de riesgo asociado.…”

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“…Improved notification of cases may also be another factor 4 . A recent study on adults who went to the Emergency Department of a university hospital in Catalonia with symptoms compatible with acute hepatitis showed that HBV infection was the main aetiological cause 5 . One third of cases were immigrants from countries with no vaccination programmes, and sexual transmission was found to be the main associated risk factor.…”

mentioning

confidence: 99%