Etiological Spectrum and Prevalence of Acute Undifferentiated Febrile Illness (AUFI) in Fever Cases Attending our Tertiary Care Centre

Veligandla, Gowri; vanan, Ezhil; Padmavathi, E.; Bhaskar, Matcha

doi:10.20546/ijcmas.2017.605.105

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…The study population comprised the majority of males. Gowri Veligandla et al (2016), in their study, reported 33.6% were children, 63.7% were adults, and 3.4% were >60 years [ 15 ]. Furthermore, Salim Mattar et al (2015), in a study reported, patient age ranged from 1 - 79 years, with the mean age of the population being 27 years.…”

Section: Discussionmentioning

confidence: 99%

Rickettsial Infections among the Undifferentiated Febrile Patients Attending a Tertiary Care Teaching Hospital of Northern India: A Longitudinal Study

et al. 2021

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Background Acute undifferentiated febrile illness (AUFI) is one of the most daunting challenges a physician faces in such settings. Among AUFI, rickettsial infections are most common and related infections (such as anaplasmosis, ehrlichiosis, and Q fever) which are caused by an unusual type of bacteria that can live only inside the cells of another organism. The present study was therefore planned with an objective to estimate the prevalence of rickettsial infection among patients of undifferentiated fever and to determine any association of socio-demographic characteristics with rickettsial disease. Materials and Methods Patients presenting with febrile illness and admitted or attending out-patient department of Sher-i-Kashmir Institute of Medical Sciences, Srinagar was approached and recruited in the study. Weil Felix Assay, enzyme-linked immunosorbent assay and indirect immunofluorescence assay were done to detect the anti-rickettsial antibodies. Serological evidence of a fourfold increase in IgG-specific antibody titer reactive with spotted fever group rickettsial antigen by indirect immunofluorescence antibody assays between paired serum specimens was considered a confirmatory diagnosis for the rickettsial disease. Results Most of the patients were males 61.6%, and most 46.2% were in the age group of 20 -39 years. Most of the patients, 80.8% belonged to rural areas, and 48% belonged to the upper middle (II) class of the socio-economic class according to modified Kuppuswamy scale. Of the studied participants, a majority, 47.0%, were determined undiagnosed, while 15.4% studied participants were diagnosed to have a rickettsial disease. In patients positive for typhus group, 67.8% were IgM positive, 28.5% were IgG positive, and only 3% were positive for IgM and IgG. In patients positive for Scrub Typhus Group, 32.7% were positive for IgM, and 62.0% were positive for IgG, and only 5.0% were positive for both IgM and IgG. In patients positive for spotted fever group, 36.1% were positive for IgM, and 58.5% were positive for IgG, and only 5.5% were positive for both IgM and IgG. The prevalence of rickettsial disease was found to be 11.3%. Conclusion Rickettsial diseases, typhoid and brucellosis, were the most prevalent diseased diagnosed among patients reporting to hospitals with undifferentiated febrile illness. Clinicians must consider rickettsial diseases as one of the differential diagnosis while treating patients with fever.

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Section: Discussionmentioning

confidence: 99%

Rickettsial Infections among the Undifferentiated Febrile Patients Attending a Tertiary Care Teaching Hospital of Northern India: A Longitudinal Study

et al. 2021

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“…14 Another examination done in Thailand announced normal manifestations of intense undifferentiated fever as headache, myalgia and vomiting. 15 In non-industrial nation like india the symptomatic board for intense undifferentiated fever incorporates first line examinations like Malaria microscopy, blood culture, Dengue rapid NS1 antigen and IgM Combo test, Leptospira IgM ELISA, Scrub typhus IgM ELISA and Chikungunya IgM ELISA. Second line testing incorporates Dengue IgM catch ELISA (MAC-ELISA), Scrub typhus immunofluorescence (IFA), Leptospira Microscopic Agglutination Test (MAT), malaria PCR and malaria immunochromatographic rapid diagnostic test (RDT).…”

Section: Discussionmentioning

confidence: 99%

Clinico – Etiological profile of Acute Undifferentiated fever in children 6 months - 15 years

Dasari¹,

Reddy²,

Nimmagadda³

et al. 2021

IJMPO

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Acute febrile illness (AFI) is defined as a patient with fever of 38 • C or higher at presentation or history of fever that persisted for 2-14 days with no localizing source. Fever is the main clinical symptom of various tropical infectious diseases. Materials and Methods: Retrospective observational examination was directed after endorsement from the Institutional Ethics Committee in Paediatric division, Apollo General Hospital, AIMSR, Jubilee hills from January 2016 till December 2019. Inclusion criteria: All the patients who were conceded in the ward or emergency unit complications of intense febrile infections, patients a half year to 15 years old were taken for the investigation. Exclusion criteria: Patients with associated infections when the complications cannot be attributed to febrile illness or patients with haematological malignancies, autoimmune disorders, and those on immunosuppressant were excluded from the study. Results : In present investigation, an aggregate of 290 patients with intense identical fever were assessed out of these 157 (63%) were male and 133 (36.6%) were female. In this investigation typhoid fever was the most well-known reason for undifferentiated fever (33.7%) trailed by malaria (25.5%), dengue fever (19.6%), urinary tract disease (8.2%), Acute gastroenteritis (5.5%), Pneumonia (3.1%), Bronchiolitis (2.4%), Hepatitis (1.0%) and Pharyngotonsillitis (0.6%%). Conclusions : It is important to know the aetiology and clinical pattern of acute undifferentiated fever for their proper management and it will help to prevent morbidity and mortality.

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“…The etiology of AUFI remains unknown even after strenuous efforts in many cases. Vector control measures, drinking water supply and sanitation should be improved to prevent vector borne and water borne diseases [7].…”

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confidence: 99%

Acute undifferentiated fever in children- an overview

Rabindran

Verma

2017

Int J Pediatr Res

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Etiological Spectrum and Prevalence of Acute Undifferentiated Febrile Illness (AUFI) in Fever Cases Attending our Tertiary Care Centre

Cited by 3 publications

References 11 publications

Rickettsial Infections among the Undifferentiated Febrile Patients Attending a Tertiary Care Teaching Hospital of Northern India: A Longitudinal Study

Rickettsial Infections among the Undifferentiated Febrile Patients Attending a Tertiary Care Teaching Hospital of Northern India: A Longitudinal Study

Clinico – Etiological profile of Acute Undifferentiated fever in children 6 months - 15 years

Acute undifferentiated fever in children- an overview

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