Abstract:Corynebacterium spp. It is associated with inflammatory diseases of the respiratory tract (tracheitis, pharyngitis, rhinosinusitis, bronchitis, pneumonia, etc.). C. pseudodiphtheriticum can be the causative agent of bacterial coinfection in patients with a new coronavirus infection (COVID-19). The aim is to determine the pathogenic properties and resistance to antimicrobial drugs of Corynebacterium spp. strains to establish their etiological significance in the development of inflammatory diseases of the respi… Show more
“…Pseudomonas aeruginosa, the most notorious of Pseudomonas, as an opportunistic pathogen and the main pathogens of nosocomial infection, can cause acute or chronic infection in patients [50,51]. In addition, Corynebacterium, which is considered as the part of the normal microbiota but also functions as a pathogen causing respiratory inflammatory diseases like tracheitis, pharyngitis, rhinosinusitis, bronchitis [52][53][54]. While in table S1, high frequency bacterial genera in healthy people [32,33,[35][36][37][39][40][41][42][43] are Veillonella, Streptococcus, Prevotella, Neisseria, Fusobacterium, Haemophilus.…”
Section: Significant Alternations In Bacterial Genera Between Healthy...mentioning
Lung microbiota and lung diseases have already received increasing attention. However, the lung microbiota lacks a unified healthy baseline. In this review, we collect the healthy pulmonary microbial composition based on the data of existing relevant studies. Subsequently, we discuss and analyze the three aspects of bacterial, fungus and viral at the phylum and genus levels, as well as influence factors like sample type, geography, age, time, hypervariable regions and sequencing method to set up a unified pulmonary baseline. We conclude that Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria and Fusobacteria are the predominant phyla in healthy people. At the genus level, the most common bacterial genera are Veillonella, Streptococcus, Prevotella, Neisseria and Fusobacterium. A significant difference exists at the bacterial genus level between the lung of healthy subjects and the normal tissues of patients, and geography impacts on the healthy baseline significantly. In addition, age, time, hypervariable regions and sequencing method all affect the baseline to various degrees. In healthy people, Ascomycota and Basidiomycota dominate the pulmonary fungal phyla, while bacteriophages are the predominated order in virome. Our investigation provides a healthy lung baseline for the study of lung microbiota, which is conducive to better finding lung disease-related pathogens.
“…Pseudomonas aeruginosa, the most notorious of Pseudomonas, as an opportunistic pathogen and the main pathogens of nosocomial infection, can cause acute or chronic infection in patients [50,51]. In addition, Corynebacterium, which is considered as the part of the normal microbiota but also functions as a pathogen causing respiratory inflammatory diseases like tracheitis, pharyngitis, rhinosinusitis, bronchitis [52][53][54]. While in table S1, high frequency bacterial genera in healthy people [32,33,[35][36][37][39][40][41][42][43] are Veillonella, Streptococcus, Prevotella, Neisseria, Fusobacterium, Haemophilus.…”
Section: Significant Alternations In Bacterial Genera Between Healthy...mentioning
Lung microbiota and lung diseases have already received increasing attention. However, the lung microbiota lacks a unified healthy baseline. In this review, we collect the healthy pulmonary microbial composition based on the data of existing relevant studies. Subsequently, we discuss and analyze the three aspects of bacterial, fungus and viral at the phylum and genus levels, as well as influence factors like sample type, geography, age, time, hypervariable regions and sequencing method to set up a unified pulmonary baseline. We conclude that Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria and Fusobacteria are the predominant phyla in healthy people. At the genus level, the most common bacterial genera are Veillonella, Streptococcus, Prevotella, Neisseria and Fusobacterium. A significant difference exists at the bacterial genus level between the lung of healthy subjects and the normal tissues of patients, and geography impacts on the healthy baseline significantly. In addition, age, time, hypervariable regions and sequencing method all affect the baseline to various degrees. In healthy people, Ascomycota and Basidiomycota dominate the pulmonary fungal phyla, while bacteriophages are the predominated order in virome. Our investigation provides a healthy lung baseline for the study of lung microbiota, which is conducive to better finding lung disease-related pathogens.
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