Etiological Research of Childhood Acute Leukemia with Cluster and Clustering Analysis

Abstract

Additional information is available at the end of the chapter http://dx.doi.org/10.5772/54456. Introduction . . The investigation of clusters of diseasesCluster disease and clustering of diseases is an aggregation of cases of a particular disease that occur within a group of people, a geographic area or a period of time, and which is higher than the researchers would expect considering its natural history, and the chance fluctuations. So far, the study of clusters has led to the identification of health problems that have spatial and temporal dimensions. "ccording to Elliot and "est, The study of the geographic patterns of a specific disease is part of the classic triad in descriptive epidemiology characterized for the time, the person, and the place [ ]. Therefore, these studies have been considered as part of Spatial analysis in Epidemiology because they can be interpreted in a temporal and spatial context they should not be confused with an ecological study as commonly happens.The space-time clustering studies describe populations in historical and geographical contexts, not individuals or population´s particularities, such as risk factors. The results of these studies must be interpreted in terms of period of time and geographic area. The space-time clustering studies are classified as follows . Spatial cluster also named geographic cluster. Is an excess of cases or events in a geographic area, which can range from a small settlement to a large region. . Temporal cluster. Is an excess of cases or events observed in a limited period of time. The results of this study must be interpreted chronologically. For example, a cluster composed of unrelated individuals whose dates of birth approximately coincide, would result in a temporary cluster however, this coincidence do not necessarily is observed in individuals that lived in the same geographic area, they could live distantly. There are clusters which individuals coincide on the time of birth, time of diagnosis, or the period in which they moved to a new city.. Space-time cluster. Is an excess of cases or events in both space and time. In other words, a space-time cluster can be observed in cases that are geographically close and are observed in the same period of time.The more common space-time clustering studies designs are spatial clusters and space-time clustering. Importantly, these types of studies should not be confused with other statistical cluster analysis methods. "oth techniques have similarities as they search characteristics of groups or other elements. However, their objectives are different, since the space-time clustering studies search groups of people in both dimensions while the statistical cluster analysis explores the strength of the relationship between words, ideas or interrelated concepts. The distinction between the two methods is even more ambiguous as is common to find them under the same term [ ].The term spatial dimension is used to refer spatial cluster. The latter research associations between individuals distributed in a geograp...

Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia

“…In Mexico, there have been limited spatial analysis studies conducted to date related to childhood leukemia. In a preliminary report, a significant spatial cluster (SC) of childhood ALL cases was detected at the eastern side of Mexico City ( 10 ). In another research, conducted in the city of Guadalajara, three SCs of ALL cases were also described ( 11 ).…”