Etiological relationship between lipid metabolism and endometrial carcinoma

Li, Wenzhe; Xu, Yi; Zeng, Xinling; Tan, Jie; Wang, Ya; Wu, Hongyan; Li, Maokun; Yi, Cunjian

doi:10.1186/s12944-023-01868-2

Cited by 5 publications

(7 citation statements)

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“…High BMI and obesity are important risk factors for the occurrence and mortality of UC, and the lipid metabolism abnormalities that obesity may bring are also closely related to the occurrence of UC [ 47 , 48 ]. Compared with UC patients with normal BMI, those with high BMI have poorer clinical outcomes and higher mortality rates.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of secular trends of three major gynecologic cancers burden and attributable risk factors from 1990 to 2019: an age period cohort analysis

Liu,

Shi,

Mubarik

et al. 2024

BMC Public Health

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Background This study aims to assess the long-term trends in the burden of three major gynecologic cancers(GCs) stratified by social-demographic status across the world from 1990 to 2019. To assess the trends of risk factor attributed mortality, and to examine the specific effects of age, period, cohort behind them in different regions. Methods We extracted data on the mortality, disability-adjusted life years(DALYs), and age-standardized rates(ASRs) of cervical cancer(CC), uterine cancer(UC), and ovarian cancer(OC) related to risks from 1990 to 2019, as GCs burden measures. Age-period-cohort analysis was used to analyze trends in attributable mortality rates. Results The number of deaths and DALYs for CC, UC and OC increased since 1990 worldwide, while the ASDRs decreased. Regionally, the ASDR of CC was the highest in low SDI region at 15.05(11.92, 18.46) per 100,000 in 2019, while the ASDRs of UC and OC were highest in high SDI region at 2.52(2.32,2.64), and 5.67(5.16,6.09). The risk of CC death caused by unsafe sex increased with age and then gradually stabilized, with regional differences. The period effect of CC death attributed to smoking showed a downward trend. The cohort effect of UC death attributed to high BMI decreased in each region, especially in the early period in middle, low-middle and low SDI areas. Conclusions Global secular trends of attributed mortality for the three GCs and their age, period, and cohort effects may reflect the diagnosis and treatment progress, rapid socioeconomic transitions, concomitant changes in lifestyle and behavioral patterns in different developing regions. Prevention and controllable measures should be carried out according to the epidemic status in different countries, raising awareness of risk factors to reduce future burden.

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Section: Discussionmentioning

confidence: 99%

“…And they will consciously adopt scientific lifestyles and diet style to control weight. In addition, dietary factors can also affect ovarian lifespan and hormone levels, affecting the age of menopause, which also may reduce the risk of adverse outcomes for UC patients [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of secular trends of three major gynecologic cancers burden and attributable risk factors from 1990 to 2019: an age period cohort analysis

Liu,

Shi,

Mubarik

et al. 2024

BMC Public Health

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“…Studies show a significantly higher prevalence of metabolic disorders following surgical menopause compared to natural menopause. This association is linked to the sudden decline in estrogen levels caused by surgery, which can lead to endothelial dysfunction, dyslipidemia [1,[26][27][28][29], and increased risk of cardiovascular events [30][31][32][33][34]. Research suggests a 1.5-fold to 9.7-fold increased risk of MetS in women who undergo surgical menopause compared to natural menopause [1,[35][36][37][38][39].…”

Section: Surgical Menopause and Increased Mets Riskmentioning

confidence: 99%

Metabolic Syndrome and Survival Outcomes in Endometrial Cancer

Marin,

Filipescu,

Vladareanu

et al. 2024

Cureus

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Menopause, through attributable estrogen level decline and the corresponding increase in circulating androgens, significantly elevates a woman's risk for cardiometabolic diseases, including metabolic syndrome (MetS), type 2 diabetes, and cardiovascular disease. Metabolic syndrome itself is a cluster of interconnected risk factors, and among them, central obesity is a well-established factor for the development of endometrial cancer (EC), the most common gynecologic malignancy. This research investigates the impact of metabolic syndrome on survival rates among patients with endometrial cancer. The goal is to assess whether having metabolic syndrome or its individual components influences disease-free survival (DFS), overall survival (OS), cancer-specific survival, and recurrence rates. Understanding this link is crucial for determining risk levels and could help tailor treatment approaches for better long-term outcomes in endometrial cancer care.

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“…Lipid modification of Rho proteins such as RhoA and Cdc42 activates microgliosis and the inflammatory signaling cascade [ 70 , 71 ] and participates in the signaling pathways required for NF-κB activity and helps regulate the transcription of proinflammatory genes. Of Note, the isoprenylation of Rho protein has emerged as a key target of neuroprotective medicines, particularly statins, in illnesses caused by neuroinflammation [ 72 ].…”

Section: Hmgcr-mediated Neuroinflammationmentioning

confidence: 99%

Mechanisms of 3-Hydroxyl 3-Methylglutaryl CoA Reductase in Alzheimer’s Disease

Zhou,

Wu,

Wang

et al. 2023

IJMS

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Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide and has a high incidence in the elderly. Unfortunately, there is no effective therapy for AD owing to its complicated pathogenesis. However, the development of lipid-lowering anti-inflammatory drugs has heralded a new era in the treatment of Alzheimer’s disease. Several studies in recent years have shown that lipid metabolic dysregulation and neuroinflammation are associated with the pathogenesis of AD. 3-Hydroxyl 3-methylglutaryl CoA reductase (HMGCR) is a rate-limiting enzyme in cholesterol synthesis that plays a key role in cholesterol metabolism. HMGCR inhibitors, known as statins, have changed from being solely lipid-lowering agents to neuroprotective compounds because of their effects on lipid levels and inflammation. In this review, we first summarize the main regulatory mechanism of HMGCR affecting cholesterol biosynthesis. We also discuss the pathogenesis of AD induced by HMGCR, including disordered lipid metabolism, oxidative stress, inflammation, microglial proliferation, and amyloid-β (Aβ) deposition. Subsequently, we explain the possibility of HMGCR as a potential target for AD treatment. Statins-based AD treatment is an ascent field and currently quite controversial; therefore, we also elaborate on the current application prospects and limitations of statins in AD treatment.

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Etiological relationship between lipid metabolism and endometrial carcinoma

Cited by 5 publications

References 100 publications

Assessment of secular trends of three major gynecologic cancers burden and attributable risk factors from 1990 to 2019: an age period cohort analysis

Assessment of secular trends of three major gynecologic cancers burden and attributable risk factors from 1990 to 2019: an age period cohort analysis

Metabolic Syndrome and Survival Outcomes in Endometrial Cancer

Mechanisms of 3-Hydroxyl 3-Methylglutaryl CoA Reductase in Alzheimer’s Disease

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