Etiological agents causing leptospirosis in Sri Lanka: A review

Naotunna, Chamidri; Agampodi, Suneth Buddhika; Agampodi, Thilini Chanchala

doi:10.1016/j.apjtm.2016.03.009

Cited by 34 publications

(34 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A systematic review performed on Sri Lankan isolates showed that more than 40 strains from 20 serovars of Leptospira have been reported from Sri Lanka 17. Our previous studies on the 2008 and 2011 outbreaks of leptospirosis in Sri Lanka expanded the knowledge of circulating Leptospira and were consistent with a diversity of Leptospira infection in Sri Lanka.…”

Section: Introductionsupporting

confidence: 58%

Study protocol: characterising the clinical, epidemiological and aetiological aspects of leptospirosis in Sri Lanka: a hospital based clinico-epidemiological study

et al. 2019

View full text Add to dashboard Cite

IntroductionSri Lanka has one of the highest incidences of leptospirosis worldwide. We hypothesised that different geographical locations and patient context will have a distinct molecular epidemiology of leptospirosis, based on microgeographical characteristics related to regiona-specificLeptospirapredominance. Our objective is to characterise the clinical, epidemiological and molecular aspects of leptospirosis in Sri Lanka to understand disease progression, risk factors and obtain isolates ofLeptospira.Methods and analysisWe designed a multicentre prospective study in Sri Lanka to recruit undifferentiated febrile patients and conduct follow-ups during hospital stays. Patients will be recruited from outpatient departments and medical wards. This study will be conducted at two main sites (Anuradhapura and Peradeniya) and several additional sites (Awissawella, Ratnapura and Polonnaruwa). Blood and urine will be collected from patients on the day of admission to the ward or presentation to the outpatient department. Bedside inoculation of 2–4 drops of venous blood will be performed with Ellinghausen-McCullough-Johnson-Harris (EMJH) semisolid media supplemented with antibiotics. Regionally optimised microscopic agglutination test, culture and qPCR-evidence will be performed to confirm the presence ofLeptospirain blood which in turn will confirm the presence of disease. Whole genome sequencing will be carried out for all isolates recovered from patients. Multilocus sequence typing (MLST) will be used for the genotyping of new isolates. Sri Lankan isolates will be identified using three published MLST schemes forLeptospira.Ethics and disseminationEthical clearance for the study was obtained from Ethics Review Committees (ERC), Medicine and Allied Sciences (FMAS), Rajarata University of Sri Lanka (RUSL) and University of Peradeniya. All genomic data generated through this project will be available at GenBank. Anonymised data will be deposited at the ERC, FMAS, RUSL.

show abstract

Section: Introductionsupporting

confidence: 58%

Study protocol: characterising the clinical, epidemiological and aetiological aspects of leptospirosis in Sri Lanka: a hospital based clinico-epidemiological study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Bakterie te są ruchliwymi, spiralnie skręconymi i cienkimi krętkami zaliczanymi do bezwzględnych tlenowców. Na świecie rocznie rejestruje się około miliona zachorowań i 58 900 przypadków śmiertelnych będących następstwem leptospirozy (4,5). Najwyższa zapadalność i śmiertelność jest obserwowana w południowej i południowo-wschodniej Azji, Oceanii, Ameryce Łacińskiej i Wschodniej Afryce (6).…”

Section: Wstępunclassified

“…Infection, caused by various species of Leptospira, is one of the zoonotic diseases, occurring all over the world, with an estimated 1.03 million annual cases and 58 999 deaths (4,5).…”

Section: Introductionmentioning

confidence: 99%

Leptospirosis in Poland in the years 2014-2017 – characteristics of infections and epidemiological surveillance data

Fiecek¹,

Lewandowska²,

Rogulska³

et al. 2018

Przegl Epidemiol

View full text Add to dashboard Cite

The aim of the study was the analysis of current Leptospira spp. infections in Poland on the basis of blood serum samples tests results and clinical data collected from clinicians in the Laboratory NIPH-NIH. METHODS. Clinical materials from 48 patients with clinical symptoms suggesting Leptospira spp suspected of leptospirosis from the years 2014-2017 were included to the study. Blood serum samples collected from patients were tested in Laboratory of Rickettsiae, Chlamydiae and Spirochaetes (currently Laboratory of Vector-borne Diseases) of NIPH-NIH. Levels of specific IgM and IgG antibodies to Leptospira spp. antigens were detected with the enzyme-linked immunosorbent assay (ELISA). RESULTS. Specific antibodies to Leptospira spp. were detected in 18 patients (37.5%). IgM antibodies were found in 6 patients (12.5%) and IgG antibodies were identified in 7 patients (14.6%). Both classes of antibodies of were detected in 5 patients (10.4%). The most samples for study were sent to laboratory from Masovian (13 samples) and Kuyavian-Pomeranian (11 samples) Voivodeships. Not any samples from the Lower Silesia, Lublin, Łódź, Podlaskie and Warmian-Masurian Voivodeships were received. In these patients the most common symptoms of disease were: fever, hepatitis with jaundice and renal failure. CONCLUSIONS. The number of diagnosed human leptospirosis in Poland is low in comparison to the number of cases in other countries, although the Leptospira spp. spirochetes occur in animals in the environment.

show abstract

“…Also the study of Ramsey, Rubin-Smith, Norwich, Katumuluwa, Hettiarachchi, Wimalage, Danushka, Madushanka, Nadeeshani, Thilakarathna, Sewwandi, Malhari, Sirisena, & Agampodi (2015) concluded that, the most striking feature of leptospirosis cases was the higher prevalence of hypotension and bradycardia in patients. In addition, the review of Naotunna & Agampodi (2016) clearly showed the diversity of leptospira in Sri Lanka. This diversity was only for the disease causing agent.…”

Section: Introductionmentioning

confidence: 99%

An Empirical Study on Human Leptospirosis Cases in the Western Province of Sri Lanka

Gnanapragasam

2017

OUSL Jnl

View full text Add to dashboard Cite

Leptospirosis is a zoonotic infectious disease in the world. It is growing as a major public health threat in Sri Lanka. The records in Sri Lanka show that, over 4000 cases were reported in the year 2016 in which nearly one fourth of total cases was reported only from the Western province. The objective of this study is to model leptospirosis cases in Western province of Sri Lanka using time series analysis. Since the purpose of forecasting is to plan the future activities, this study will support in term of planning the programmes of control for future.Appropriate tests were employed for the preliminary analysis to study the behavior of provinces-wise and district-wise distribution of leptospirosis cases in Sri Lanka. Seasonal Autoregressive Integrated Moving Average (SARIMA) models were developed using standard techniques. Diagnostic tests for tentatively fitted models were checked. In addition, for the purpose of selecting the best model, usual selection criteria were used. Finally, mean absolute percentage error was used to measure the accuracy of forecasting.The results show that, Western province (28.41%) is the mostly affected part of the island by human leptospirosis. Moreover, Gampaha (10.78%), Kalutara (9.59%) and Colombo (8.04%) districts in Western province are ranked among the first 5 districts of Sri Lanka based on average number of recorded cases. The accuracy of the fitted SARIMA (1, 0, 0)(0, 1, 1)12 model is over 85%. Therefore, it can be used to forecast future leptospirosis cases in the Western province. Based on the fitted model, the expected number of new cases in the Western province for the year 2017 is estimated to be 1168.

show abstract

Etiological agents causing leptospirosis in Sri Lanka: A review

Abstract: This review shows the diversity of Leptospira in Sri Lanka, but culture isolation data has not been published in Sri Lanka during last 30 years.

Cited by 34 publications

References 28 publications

Study protocol: characterising the clinical, epidemiological and aetiological aspects of leptospirosis in Sri Lanka: a hospital based clinico-epidemiological study

Study protocol: characterising the clinical, epidemiological and aetiological aspects of leptospirosis in Sri Lanka: a hospital based clinico-epidemiological study

Leptospirosis in Poland in the years 2014-2017 – characteristics of infections and epidemiological surveillance data

An Empirical Study on Human Leptospirosis Cases in the Western Province of Sri Lanka

Contact Info

Product

Resources

About