Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion

Stray‐Pedersen, Babill; Stray‐Pedersen, Sverre

doi:10.1016/s0002-9378(84)80164-7

Cited by 450 publications

(165 citation statements)

References 10 publications

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“…Some studies additionally included weekly nonstress testing beginning at 26-30 weeks (44,49). Previous studies established the impact of supportive care alone in women with unexplained recurrent miscarriage; supportive care only resulted in live-birth rates of Ͼ85% (57)(58)(59). Taken together, these data support the hypothesis that recognition of aPL as a risk factor for adverse pregnancy outcome by itself contributed significantly to higher live-birth rates in aPL-positive women who received treatment during their pregnancies (32,44,(51)(52)(53)(54)(55).…”

Section: Discussionmentioning

confidence: 99%

Management of the obstetric antiphospholipid syndrome

Derksen¹,

Khamashta²,

Branch³

2004

Arthritis & Rheumatism

185

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Section: Discussionmentioning

confidence: 99%

Management of the obstetric antiphospholipid syndrome

Derksen¹,

Khamashta²,

Branch³

2004

Arthritis & Rheumatism

185

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“…The infl uence of these factors on the origin of RSA is still a matter of discussion in the literature. 5,7 Nevertheless, when synechiae, uterine septa, polyps, myomas or cervical incompetence were diagnosed, treatment was given. It is possible that these corrections may have contributed towards better pregnancy outcomes among the women of the present study, as also reported by some other authors.…”

Section: Discussionmentioning

confidence: 99%

“…6 Uterine anatomical defects and an incompetent cervix predispose women to abortion and premature delivery, accounting for 15 to 27% of RSA cases. 5,7 Changes in hormonal patterns have also been implicated as causes of RSA. Low progesterone production renders endometrial maturation inadequate for nidation and egg development.…”

Section: Introductionmentioning

confidence: 99%

Gestational prognostic factors in women with recurrent spontaneous abortion

et al. 2006

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CONTEXT AND OBJECTIVE: Recurrent spontaneous abortion (RSA) is defined as three or more consecutive pregnancy losses before 20 weeks and is associated with several etiological factors related to genetics, anatomy, hormones, infections and immunology, for example. Many cases of RSA remain unclear. New factors or their associations may influence gestational results. The aim was to identify possible single or associated causes of RSA that could predict gestational prognosis for women undergoing investigation and treatment. DESIGN AND SETTING: Case-control study, at the Recurrent Abortion Outpatient Clinic, Department of Obstetrics and Gynecology School of Medicine, Universidade Estadual de Campinas (Unicamp). METHODS: Two hundred and forty-six medical records of women with RSA seen at the Recurrent Abortion Outpatient Clinic, Department of Obstetrics and Gynecology School of Medicine, Universidade Estadual de Campinas (Unicamp), between 1994 and 2003, were evaluated. Data on age, obstetric history, possible etiological factors, treatment and pregnancy outcomes were evaluated. Statistical analysis was performed using odds ratios (OR), logistic regression analysis and decision trees. RESULTS: Two hundred and twenty-nine women were included in the study. The most frequently found etiological factors were immunological, particularly alloimmune factors (93.9%). Women with a single alloimmune factor had better gestational results (77.7% deliveries) than those with other associated factors. Autoimmune factors were associated with a higher abortion rate (OR: 4.30; 95% confidence interval, CI: 1.36-13.63). No association was found between the number of abortions prior to treatment and pregnancy results. Women aged 40 or over presented the highest rate of spontaneous abortion (OR: 5.83; 95% CI: 1.12-30.40). CONCLUSION: Age over 40 years old, immunological factors and two or more concomitant factors were associated with poor gestational outcomes among the women studied.

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“…It is the most common complication of early pregnancy [2]. Spontaneous abortion is seen in 10-15 % of all clinically recognised pregnancies [3][4][5]. A spontaneous abortion is as opposed to an induced abortion which is purely accidental, that is spontaneous.…”

Section: Introductionmentioning

confidence: 99%

A functional polymorphism in the promoter region of interleukin-10 gene increases the risk for spontaneous abortions—a triad study

Vidyadhari

Sujatha

Krupa³

et al. 2015

J Assist Reprod Genet

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Purpose Spontaneous abortion or miscarriage is the natural death of an embryo or foetus in the early stages of prenatal development. Interleukin-10 is an anti-inflammatory cytokine, produced by human cytotrophoblasts, and defects in its production result in specific pathological conditions during pregnancy. The present study is aimed to evaluate the association of IL-10 -1082G/A polymorphism in spontaneous abortions by comparing foetal, maternal and paternal groups-a triad study. Methods A total of 50 families with spontaneous abortions and 60 families with medically terminated pregnancies were considered for the present study. DNA from foetal tissue and parental blood samples were extracted, and the genotype analysis of IL-10 -1082G/A promoter polymorphism was carried out by amplification refractory mutation system-polymerase chain reaction followed by agarose gel electrophoresis. A statistical analysis was applied to test for the significance of the results. Results There was a statistically significant difference in the distribution of AA genotypes and A allele of IL-10 -1082G/A between the two family groups among foetuses (P=0.0002) and mothers (P=0.00005).

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Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion

Cited by 450 publications

References 10 publications

Management of the obstetric antiphospholipid syndrome

Management of the obstetric antiphospholipid syndrome

Gestational prognostic factors in women with recurrent spontaneous abortion

A functional polymorphism in the promoter region of interleukin-10 gene increases the risk for spontaneous abortions—a triad study

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