Etiología y evaluación diagnóstica en la insuficiencia cardíaca

Cubero, Javier Segovia; Rivera, Luís E.; Moral, Roberto Peraira; Silva-Melchor, Lorenzo

doi:10.1016/s0300-8932(04)77097-9

Cited by 22 publications

(2 citation statements)

References 39 publications

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“…Some CHD, such as tetralogy of Fallot, pulmonary atresia with ventricular septal defect (PA+VSD), pulmonary valve stenosis (PVS), and type C Ebstein's anomaly ( 4 , 5 ) share the common obstructive factor of right ventricle outflow tract, which leads to right ventricle pressure overload. This mechanism, along with additional factors such volume overload secondary to left-to-right shunts, favors the development of RVD.…”

Section: Introductionmentioning

confidence: 99%

Tei Index Is the Best Echocardiographic Parameter for Assessing Right Ventricle Function in Patients With Unrepaired Congenital Heart Diseases With Outflow Tract Obstruction

et al. 2018

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Objective: Magnetic resonance imaging (MRI) and cardiac catheterization are diagnostic tools for right ventricle dysfunction (RVD), but those are expensive and often unavailable techniques. Thus, our objective was to identify clinical and/or echocardiographic variables capable of predicting a catheterization-based diagnosis of RVD.Design: This was cross-sectional, diagnostic test accuracy study, considering the catheterization-based diagnosis of RVD as the gold standard.Patients: Pediatric patients with non-repaired CHD with overload pressure were evaluated. Clinical variables (edema and functional class), transthoracic echocardiography (right heart dimensions, systolic and diastolic function, Doppler velocities), and cardiac catheterization (pressures and right ventricle systolic work measurements) were obtained during the same hospitalization.Results: We included 253 patients with tetralogy of Fallot (39.9%), pulmonary atresia with ventricular septal defect (33.9%), type C Ebstein's anomaly (15.8%), or pulmonary stenosis (10.4%). Among clinical (vascular congestion, functional class derangement) and echocardiographic (indexed right ventricle diameter, fractional area change, tricuspid annular plane systolic excursion, S' wave, Tei index) variables, the Tei index (defined as the ratio of isovolumetric contraction time to ejection time) was the sole variable that exhibited high diagnostic capability, with 98.5% sensitivity, 97.4% specificity, 97.8% positive predictive value, and 98.3% negative predictive value, with 98.0% overall performance. Multivariate logistic regression confirmed that Tei index alone predicted the catheterization-based diagnosis of RVD.Conclusions: Tei index is the best parameter that can be employed for the non-invasive identification of RVD in patients with CHD.

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Section: Introductionmentioning

confidence: 99%

Tei Index Is the Best Echocardiographic Parameter for Assessing Right Ventricle Function in Patients With Unrepaired Congenital Heart Diseases With Outflow Tract Obstruction

et al. 2018

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“…Although the etiology highly varies, heart failure is due to a derangement of interplay among the cardiac, renal, and vascular systems (Segovia Cubero et al, 2004). Among clinical causes of heart failure, cardiac hypertrophy and mitochondrial dysfunction are two important factors.…”

Section: Heart Failurementioning

confidence: 99%

Network-based approaches to studying healthy and disease development

Gao¹

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ii To my family and friends, for their support iii ACKNOWLEDGMENTS First, I would like to thank my thesis advisor, Dr. Kai Tan, for his mentorship and support during the past six years. Kai has provided me with excellent guidance and encouragement throughout my graduate training. He has invested a large amount of time in my individual success and I will always be grateful for his patience and dedication to my development. Under his advice and support I was able to develop my skills as an independent computational biologist.

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