Ethylicin Inhibition of Xanthomonas oryzae pv. oryzicola In Vitro and In Vivo

Huang, Yajiao; Li, Hongde; Zhao, Guili; Bai, Qian; Huang, Min; Luo, Dan; Li, Xiangyang

doi:10.1021/acs.jafc.2c07327

Cited by 4 publications

(2 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, ethylicin (ET) is a bionic bactericide inspired by allicin in garlic. 42 Previously, we have elucidated the underlying mechanism of ET-induced resistance to Xoo in rice by employing plant physiological and biochemical studies and transgenic technology. 43 This process entails the enhancement of defense enzymes by ET, modulation of the abscisic acid (ABA) signaling pathway, and induction of increased expression of OsCPK24 in rice, which serves as a mediator responsible for resistance to Xoo.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In recent years, 1,3,4-oxadiazole-containing structures have aroused widespread awareness from many researchers because of their broad spectrum and highly effective antibacterial activities against plant pathogens. − In addition, disulfide (S–S) is an extremely promising chemical moiety frequently found in the structure of many naturally occurring small molecules and proteins (Figure b). For instance, ethylicin (ET) is a bionic bactericide inspired by allicin in garlic . Previously, we have elucidated the underlying mechanism of ET-induced resistance to Xoo in rice by employing plant physiological and biochemical studies and transgenic technology .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Design, Synthesis, Antibacterial Activity, and Mechanisms of Novel Benzofuran Derivatives Containing Disulfide Moieties

Li,

Liu,

et al. 2024

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

The unsatisfactory effects of conventional bactericides and antimicrobial resistance have increased the challenges in managing plant diseases caused by bacterial pests. Here, we report the successful design and synthesis of benzofuran derivatives using benzofuran as the core skeleton and splicing the disulfide moieties commonly seen in natural substances with antibacterial properties. Most of our developed benzofurans displayed remarkable antibacterial activities to frequently encountered pathogens, including Xanthomonas oryzae pv oryzae (Xoo), Xanthomonas oryzae pv oryzicola (Xoc), and Xanthomonas axonopodis pv citri (Xac). With the assistance of the three-dimensional quantitative constitutive relationship (3D-QSAR) model, the optimal compound V40 was obtained, which has better in vitro antibacterial activity with EC 50 values of 0.

show abstract

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, Antibacterial Activity, and Mechanisms of Novel Benzofuran Derivatives Containing Disulfide Moieties

Li,

Liu,

et al. 2024

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

Excellent Foliar Deposition of Cyclodextrin‐Encapsulated Furyl/Thienyl‐Engineered Ingredients: Novel Effective Supramolecular Agrochemicals for Combating Plant Bacterial and Fungal Infections

Dai,

Yang,

Fan

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Repeated epidemics caused by bacterial and fungal diseases pose a threat to global crop yields and food security, therefore, updating the structure of existing microbicides and improving the pesticide bioavailability are challenging tasks, perhaps planning to develop versatile supramolecular antimicrobial materials. Here, a low‐cost multifunctional supramolecular complex, named FT6@β‐CD, is constructed by host‐guest encapsulation of a thienyl‐engineered ingredient (FT6) into β‐cyclodextrin. This integrated architecture can significantly reduce the bounce and splash behaviors of droplets, improve the wetting performance, and eventually acquire excellent foliar deposition and targeted delivery. Whereafter, FT6@β‐CD can inhibit the transcription of type III secretion system (T3SS)‐associated genes, hypersensitive reaction, and final pathogenicity from a destructive pathogen Xanthomonas oryzae pv. oryzae (Xoo). Importantly, at a lower dosage of 200 µg mL−1, FT6@β‐CD presented excellent in vivo control effects (protection 48.1%, curative 50.1%) against Xoo, remarkably better than the commercial bactericidal formulation thiodiazole‐copper. Additionally, other supramolecular antifungal materials (FT24/FT25@HP‐β‐CD/β‐CD/Me‐β‐CD) constructed in this study can effectively treat Botryosphaeria dothidea and Botrytis cinerea with higher control efficiencies of 86.8% and 90.1% at 200 µg mL−1, respectively. This study provides a bright guidance for developing low‐cost, green, and eco‐friendly supramolecular microbicides for controlling agricultural diseases.

show abstract

Synthesis and agricultural antimicrobial evaluation of new quinazoline derivatives containing both a piperazine linker and the N‐acetyl moiety

An,

Yang,

Yan

et al. 2024

Pest Management Science

View full text Add to dashboard Cite

BACKGROUNDTo discover more efficient agricultural antimicrobial agents, a series of new quinazoline derivatives containing both a piperazine linker and the N‐acetyl moiety were prepared and assessed for their antibacterial and antifungal activities.RESULTSAll the target compounds were characterized by 1H and 13C NMR as well as high‐resolution mass spectrometry (HRMS), and the chemical structure of the most potent compound E19 incorporating a 4‐trifluoromethoxy substituent was clearly confirmed via single crystal X‐ray diffraction measurements. The bioassay results indicated that some compounds possessed notable inhibitory effects in vitro against the bacterium Xanthomonas oryzae pv. oryzicola (Xoc). For example, compound E19 had an EC50 (effective concentration for 50% activity) value of 7.1 μg/mL towards this pathogen, approximately 15‐ and 10‐fold more effective than the commercial bactericides thiodiazole copper and bismerthiazol (EC50 = 110.2 and 72.4 μg/mL, respectively). Subsequently, the mechanistic studies showed that compound E19 likely exerted its antibacterial efficacies by altering the cell morphology, increasing the permeability of bacterial cytoplasmic membrane, suppressing the production of bacterial extracellular polysaccharides and the extracellular enzyme activities (amylase and cellulase), and blocking the swimming motility of Xoc. Moreover, the proteomic analysis revealed that compound E19 could reduce the bacterial flagellar biosynthesis and decrease the flagellar motility by down‐regulating the expression of the related differential proteins.CONCLUSIONCompound E19 exhibited good potential for further development as a bactericide candidate for control of Xoc. © 2024 Society of Chemical Industry.

show abstract

Ethylicin Inhibition of Xanthomonas oryzae pv. oryzicola In Vitro and In Vivo

Cited by 4 publications

References 55 publications

Design, Synthesis, Antibacterial Activity, and Mechanisms of Novel Benzofuran Derivatives Containing Disulfide Moieties

Design, Synthesis, Antibacterial Activity, and Mechanisms of Novel Benzofuran Derivatives Containing Disulfide Moieties

Excellent Foliar Deposition of Cyclodextrin‐Encapsulated Furyl/Thienyl‐Engineered Ingredients: Novel Effective Supramolecular Agrochemicals for Combating Plant Bacterial and Fungal Infections

Synthesis and agricultural antimicrobial evaluation of new quinazoline derivatives containing both a piperazine linker and the N‐acetyl moiety

Contact Info

Product

Resources

About