Ethylenediaminetetraacetic acid induces antioxidant and anti-inflammatory activities in experimental liver fibrosis

Abstract

This study demonstrates that EDTA treatment induces the activity of antioxidant enzymes, decreases lipid peroxidation, hepatic inflammation, and fibrosis in experimental liver fibrosis induced by CCl(4).

Enhancing Antitumor Efficacy of Cisplatin Low Dose by EDTA in Ehrlich Ascetic Carcinoma Bearing Mice

“…Consistent with our findings, treatment with liposomes loaded with EDTA alone did not show any antitumor effects, however, liposomes loaded with EDTA and doxorubicin could significantly reduce drug toxicity without altering the antitumor activity [7]. EDTA administration enhances the antioxidant enzymes activity and decreases the hepatic inflammation and lipid peroxidation in carbon tetrachloride (CCl4)-induced liver fibrosis [8]. Cisplatin (Cis) is one of the most clinical chemotherapeutic drugs used for treatment of different types of cancer including bladder and cervical cancers [9,10].…”

“…Ethylene diamine tetra-acetic acid (EDTA) has some medical and therapeutic uses such as metal chelator in treatment of lead and iron toxicity [6]. The chelation properties of EDTA are also employed to prevent blood coagulation [7], preserve ophthalmic preparations [8] and to decrease the complications of certain types of anemia and blood transfusion [9]. The Cr (III) complex with EDTA is used in medical diagnosis to assess the glomerular filtration rate [10].…”

Effects of trace mineral injections on measures of performance and trace mineral status of pre- and postweaned beef calves1

“…However, a Institue for Health and Consumer Products (2004) report found no evidence of inflammatory distress among rodents receiving high doses of EDTA orally and generally concluded EDTA to be exceedingly safe for a variety of industrial and pharmaceutical applications. Furthermore, EDTA has also been shown to possess anti-inflammatory actions by inducing antioxidant enzyme activity and reducing lipid peroxidation in rodents challenged with a carcinogenic substance (González-Cuevas et al, 2011).…”

Effects of prostasomes on functional parameters of fresh and cryopreserved-thawed spermatozoa of crossbred Karan Fries (KF) bulls

“…A transfer of cholesterol from prostasomes to spermatozoa has been proposed as a mechanism that stabilizes sperm membrane and reduces its lipid peroxidation (Cross and Mahasreshti, 1997). However, a slight reduction in ROS production observed in control might be due to the antioxidant activity of EDTA present in sp-TALP, as EDTA prevents cellular lipid peroxidation (González-Cuevas et al, 2011).…”