Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: Their evaluation as inhibitors of SIRT1

Manjulatha, K.; Srinivas, S.; Mulakayala, Naveen; Rambabu, D.; Prabhakar, Maddela; Arunasree, Kalle M.; Alvala, Mallika; Rao, Mandava V. Basaveswara; Pal, Manojit

doi:10.1016/j.bmcl.2012.08.017

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Oriental Journal Of Chemistry1

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Cited by 38 publications

(15 citation statements)

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“…20 Some aurone analogues have been recently identified by Manjulatha et al as SIRT1 inhibitors. 21 In the frame of our research involving the design, synthesis and activity evaluation of aurones, a series of 20 natural and synthetic analogues were tested for their zinc-dependent HDAC inhibitory activity.…”

Section: Introductionmentioning

confidence: 99%

Aurones as histone deacetylase inhibitors: Identification of key features

Zwick

Chatzivasileiou

Deschamps

et al. 2014

Bioorganic & Medicinal Chemistry Letters

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Section: Introductionmentioning

confidence: 99%

Aurones as histone deacetylase inhibitors: Identification of key features

Zwick

Chatzivasileiou

Deschamps

et al. 2014

Bioorganic & Medicinal Chemistry Letters

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“…These have been reported to possess antimicrobial 35 , antioxidant 36,37 , anticancer 38 and anti-inflammatory 39 activities.…”

Section: Oriental Journal Of Chemistrymentioning

confidence: 99%

Synthesis and Antibacterial Screening of Novel Fluorine Containing Heterocycles

Karale¹,

Takate²,

Salve³

et al. 2015

Orient. J. Chem

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A Claisen-Schimidt condensation of 2-hydroxyacetophenones 1a-f with an aldehyde 2 yielded a series of compounds 3a-f. Compounds 3a-f were transformed into series of substituted chromones 4a-f, pyrazolines 5a-f and aurones 6a-f on treatment with DMSO/ I 2 , NH 2 NH 2 / EtOH and Hg(OAc) 2 / pyridine respectively. All these novel compounds were characterized by spectral techniques. All the compounds were screened for their antibacterial potential.

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“…The most commonly used method for the synthesis of aurones involves the aldol condensation of benzofuran-3(2H)-ones with aromatic aldehyde. This reaction can be carried out by using alumina (Varma and Varma, 1992;Loser et al, 2004;Morimoto et al, 2007), HCl (Feuerstein and Kostanecki, 1898), EDDA (Manjulatha et al, 2012), and deep eutectic solvent (Hawkins and Handy, 2013). However, considering the importance of aurones, we devised a simple, green, and economically viable method for their synthesis.…”

Section: Introductionmentioning

confidence: 99%