Ethylene oxide sterilization in the medical‐supply manufacturing industry: Assessment and control of worker exposure

Chien, Yeh-Chung; Liu, Hung-Hsin; Lin, Yi-Chang; Su, Po-Chi; Li, Lien-Hsiung; Chang, Cheng-Ping; Tang, Da-Toung; Chen, Chang-Yuh

doi:10.1002/jbm.b.30825

Cited by 11 publications

(17 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are consistent with previous studies on EO-exposed workers in hospitals that most exposures occurred when handling the sterilization equipment EO exposure was negligible. 12 Exposed workers have greater HEV levels than the smokers, suggesting that some of the workers might have been exposed to greater amounts of EO than the smokers.…”

Section: Discussionmentioning

confidence: 97%

Analysis of hydroxyethyl valine in hospital sterilization workers

Huang

Chiang

Duann

et al. 2012

Genomic Medicine, Biomarkers, and Health Sciences

View full text Add to dashboard Cite

The formation of N-(2-hydroxyethyl) valine (HEV) in hemoglobin has been considered as a biologically effective dose for exposures to ethylene oxide (EO). In this study, 148 volunteers with no EO exposure history and 76 EO-exposed hospital sterilization workers in Taiwan were recruited, 10 ml of blood was collected, and background information was gathered using questionnaires from each study subject. HEV was processed by following the modified Edman degradation method and quantitated using a gas chirography coupled with mass spectrometry. Statistical analysis shows that the formation of HEV was significantly associated with smoking status and EO exposure.

show abstract

Section: Discussionmentioning

confidence: 97%

Analysis of hydroxyethyl valine in hospital sterilization workers

Huang

Chiang

Duann

et al. 2012

Genomic Medicine, Biomarkers, and Health Sciences

View full text Add to dashboard Cite

show abstract

“…Due to its effective bactericidal, sporicidal, and virucidal activity, use of EO in sterilization is considered the most cost-effective process, particularly for heat-sensitive medical devices (Mendes, Brandão, & Silva, 2007). Short-term EO exposures were reported at a time-weighed average of 7.35 and 27.6 ppm during unloading of medical devices in medical-supply manufacturing industries (Chien et al, 2007). EO exposures for sterilization workers in hospitals were much less than 1 ppm, and were estimated to vary from 0.03 to 0.36 ppm or from 0.009 to 0.18 ppm (Yong et al, 2007;Haufroid et al, 2007).…”

Section: Eo Exposuresmentioning

confidence: 99%

The application of mass spectrometry in molecular dosimetry: Ethylene oxide as an example

Chiang

Shih

et al. 2011

Mass Spectrometry Reviews

View full text Add to dashboard Cite

Mass spectrometry plays an increasingly important role in the search for and quantification of novel chemically specific biomarkers. The revolutionary advances in mass spectrometry instrumentation and technology empower scientists to specifically analyze DNA and protein adducts, considered as molecular dosimeters, derived from reactions of a carcinogen or its active metabolites with DNA or protein. Analysis of the adducted DNA bases and proteins can elucidate the chemically reactive species of carcinogens in humans and can serve as risk-associated biomarkers for early prediction of cancer risk. In this article, we review and compare the specificity, sensitivity, resolution, and ease-of-use of mass spectrometry methods developed to analyze ethylene oxide (EO)-induced DNA and protein adducts, particularly N7-(2-hydroxyethyl)guanine (N7-HEG) and N-(2-hydroxyethyl)valine (HEV), in human samples and in animal tissues. GC/ECNCI-MS analysis after HPLC cleanup is the most sensitive method for quantification of N7-HEG, but limited by the tedious sample preparation procedures. Excellent sensitivity and specificity in analysis of N7-HEG can be achieved by LC/MS/MS analysis if the mobile phase, the inlet (split or splitless), and the collision energy are properly optimized. GC/ECNCI-HRMS and GC/ECNCI-MS/MS analysis of HEV achieves the best performance as compared with GC/ECNCI-MS and GC/EI-MS. In conclusion, future improvements in high-throughput capabilities, detection sensitivity, and resolution of mass spectrometry will attract more scientists to identify and/or quantify novel molecular dosimeters or profiles of these biomarkers in toxicological and/or epidemiological studies.

show abstract

“…Recently a special focus is placed on the use of self assembled block copolymer in pharmaceutical and biomedical applications 5 .In most cases the hydrophobic groups are either alkyl chains, from octyl to octadecyl, or contain an aromatic ring (phenyl, naphthyl, pyrenyl, etc. ).…”

Section: Oriental Journal Of Chemistrymentioning

confidence: 99%

Synthesis and Characterization of Novel Amphiphilic Block Copolymer poly(4-vinyl benzene chloride)-b-poly(ethylene oxide)

Nemiche¹,

Sebba²,

Ould-Kada³

2013

Orientjchem.

View full text Add to dashboard Cite

We have synthesis and characterization of a novel block copolymer containing poly (ethylene oxide) (PEO) as hydrophilic segment, and poly (4-vinyl benzene chloride) PVBC as hydrophobic segment. The synthesis of these block copolymer poly (4-vinyl benzene chloride)-bpoly(ethylene oxide) was achieved by using the direct method which deals with starting of VBC by H 2 SO 4 as iniator, followed by deactivation of the macrocation by PEO. The structure of the model compounds was confirmed by spectral analyses. The various characteristics of the resulting amphiphilc copolymers including: FT-IR, 1 H NMR, GPC, DRX(SAXS), AFM and thermal analysis by DSC, analysis of critical micelle concentration CMC were determined and discussed.

show abstract

Ethylene oxide sterilization in the medical‐supply manufacturing industry: Assessment and control of worker exposure

Cited by 11 publications

References 19 publications

Analysis of hydroxyethyl valine in hospital sterilization workers

Analysis of hydroxyethyl valine in hospital sterilization workers

The application of mass spectrometry in molecular dosimetry: Ethylene oxide as an example

Synthesis and Characterization of Novel Amphiphilic Block Copolymer poly(4-vinyl benzene chloride)-b-poly(ethylene oxide)

Contact Info

Product

Resources

About