Ethylene oxide and risk of lympho-hematopoietic cancer and breast cancer: a systematic literature review and meta-analysis

Marsh, Gary M.; Keeton, Kara A; Riordan, Alexander S; Best, Elizabeth; Benson, Stacey

doi:10.1007/s00420-019-01438-z

Cited by 24 publications

(7 citation statements)

References 41 publications

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“…The results of epidemiology studies, however, have been inconclusive. Increases in certain types of cancers were reported in a large study of sterilant workers Steenland et al 2003); but these elevations were not seen consistently in other studies, including in a more heavily exposed cohort of chemical workers, followed over an extended time period (Marsh et al 2019;Swaen et al 2009). USEPA (2016) reassessed the cancer potency of ethylene oxide on its IRIS database resulting in the derivation of a unit risk value (a quantitative estimate of cancer potency) that is approximately 50-fold higher (i.e.…”

Section: Introductionmentioning

confidence: 88%

Ethylene oxide review: characterization of total exposure via endogenous and exogenous pathways and their implications to risk assessment and risk management

Kirman

Sheehan

et al. 2020

Journal of Toxicology and Environmental Health, Part B

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Section: Introductionmentioning

confidence: 88%

Ethylene oxide review: characterization of total exposure via endogenous and exogenous pathways and their implications to risk assessment and risk management

Kirman

Sheehan

et al. 2020

Journal of Toxicology and Environmental Health, Part B

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“…Our results reflect two previous meta-analyses on the association between occupational exposure duration to chemical agents and four other types of cancer: which reported a significantly increased risk of lung and colorectal cancer in workers with > 20 years exposure to chemical agents [ 5 , 6 ]. Two meta-analyses reported no statistically significant dose-response association between occupational exposure duration to chemical agents and stomach cancer [ 4 ] or breast cancer [ 7 ]. These different results may be due to differences in exposure duration definitions.…”

Section: Discussionmentioning

confidence: 99%

Duration–response association between occupational exposure and pancreatic cancer risk: meta-analysis

Boonhat

Pratama

Lin

et al. 2023

Occupational Medicine

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Background Evidence is lacking on the occupational exposure time window to chemical agents related to pancreatic cancer risk. Aims This study performed meta-regression and meta-analysis to examine the dose–response association between occupational exposure duration to chemical agents and pancreatic cancer risk. Methods We searched and reviewed studies on exposure duration and pancreatic cancer in five databases (Cochrane Library, EMBASE, PubMed, ScienceDirect and Web of Science) from inception to 16 May 2022. Exposure refers to the years a worker was exposed to any chemical agent, and outcome variables were pancreatic cancer incidence and mortality. Results We identified 31 studies, including 288 389 participants. In the meta-regression, the positive dose–response association indicated pancreatic cancer risk increased slightly with every additional year of exposure duration (slope = 1.01; 95% confidence interval [CI] 1.00–1.02). Pancreatic cancer risk increased with an exposure duration of 1–10 (relative risk [RR] = 1.04; 95% CI 1.02–1.06), 11–20 (RR = 1.11; 95% CI 1.05–1.16), and 21–30 years (RR = 1.39; 95% CI 1.12–1.73). Conclusions Pancreatic cancer risk increased as occupational exposure duration increased, with an exposure time window ranging from 1 to 30 years.

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“…Human Effects: There is no evidence of adverse health effects related to the consumption contaminated foods, mainly due to the rapid breakdown of EtO. While some epidemiological studies report association between occupational exposure (primarily through inhalation) to EtO and higher risk of lympho-haematopoietic [ 512 ] and breast cancers [ 513 ], the evidence is limited and not supported by meta-analysis studies [ 68 , 275 , 487 , 489 , 514 , 515 , 516 ].…”

Section: Dna-reactive Carcinogens and Related Chemicals Present In Foodmentioning

confidence: 99%

Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk

Kobets

Smith

Williams

2022

Foods

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Commonly consumed foods and beverages can contain chemicals with reported carcinogenic activity in rodent models. Moreover, exposures to some of these substances have been associated with increased cancer risks in humans. Food-borne carcinogens span a range of chemical classes and can arise from natural or anthropogenic sources, as well as form endogenously. Important considerations include the mechanism(s) of action (MoA), their relevance to human biology, and the level of exposure in diet. The MoAs of carcinogens have been classified as either DNA-reactive (genotoxic), involving covalent reaction with nuclear DNA, or epigenetic, involving molecular and cellular effects other than DNA reactivity. Carcinogens are generally present in food at low levels, resulting in low daily intakes, although there are some exceptions. Carcinogens of the DNA-reactive type produce effects at lower dosages than epigenetic carcinogens. Several food-related DNA-reactive carcinogens, including aflatoxins, aristolochic acid, benzene, benzo[a]pyrene and ethylene oxide, are recognized by the International Agency for Research on Cancer (IARC) as causes of human cancer. Of the epigenetic type, the only carcinogen considered to be associated with increased cancer in humans, although not from low-level food exposure, is dioxin (TCDD). Thus, DNA-reactive carcinogens in food represent a much greater risk than epigenetic carcinogens.

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Ethylene oxide and risk of lympho-hematopoietic cancer and breast cancer: a systematic literature review and meta-analysis

Cited by 24 publications

References 41 publications

Ethylene oxide review: characterization of total exposure via endogenous and exogenous pathways and their implications to risk assessment and risk management

Ethylene oxide review: characterization of total exposure via endogenous and exogenous pathways and their implications to risk assessment and risk management

Duration–response association between occupational exposure and pancreatic cancer risk: meta-analysis

Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk

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